8Q6P
| X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA replication licensing factor mcm2, DNA replication licensing factor mcm4-B, ... | 著者 | Butryn, A, Cvetkovic, M.A, Costa, A. | 登録日 | 2023-08-14 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
|
|
8Q6O
| X. laevis CMG dimer bound to dimeric DONSON - without ATPase | 分子名称: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | 著者 | Butryn, A, Cvetkovic, M.A, Costa, A. | 登録日 | 2023-08-14 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The structural mechanism of dimeric DONSON in replicative helicase activation. Mol.Cell, 83, 2023
|
|
7Z13
| S. cerevisiae CMGE dimer nucleating origin DNA melting | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | 著者 | Lewis, J.S, Sousa, J.S, Costa, A. | 登録日 | 2022-02-24 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
|
|
7ZPP
| Cryo-EM structure of the MVV CSC intasome at 4.5A resolution | 分子名称: | Integrase, vDNA, non-transferred strand, ... | 著者 | Ballandras-Colas, A, Maskell, D, Pye, V.E, Locke, J, Swuec, S, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2022-04-28 | 公開日 | 2022-05-11 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration Science, 355, 2017
|
|
6HV9
| S. cerevisiae CMG-Pol epsilon-DNA | 分子名称: | Cell division control protein 45, DNA (5'-D(*GP*CP*AP*GP*CP*CP*AP*CP*GP*CP*TP*GP*GP*CP*CP*GP*TP*TP*TP*TP*A)-3'), DNA (5'-D(P*TP*AP*AP*AP*AP*CP*GP*GP*CP*CP*AP*GP*CP*GP*TP*GP*GP*CP*TP*GP*C)-3'), ... | 著者 | Abid Ali, F, Purkiss, A.G, Cheung, A, Costa, A. | 登録日 | 2018-10-10 | 公開日 | 2018-12-12 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (4.98 Å) | 主引用文献 | Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome. Nat Commun, 9, 2018
|
|
6HV8
| Cryo-EM structure of S. cerevisiae Polymerase epsilon deltacat mutant | 分子名称: | DNA polymerase epsilon catalytic subunit A, DNA polymerase epsilon subunit B, ZINC ION | 著者 | Goswami, P, Purkiss, A, Cheung, A, Costa, A. | 登録日 | 2018-10-10 | 公開日 | 2018-12-12 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome. Nat Commun, 9, 2018
|
|
6RNY
| PFV intasome - nucleosome strand transfer complex | 分子名称: | DNA (108-MER), DNA (128-MER), DNA (33-MER), ... | 著者 | Pye, V.E, Renault, L, Maskell, D.P, Cherepanov, P, Costa, A. | 登録日 | 2019-05-09 | 公開日 | 2019-09-25 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
|
|
5M0R
| Cryo-EM reconstruction of the maedi-visna virus (MVV) strand transfer complex | 分子名称: | integrase, tDNA, vDNA, ... | 著者 | Pye, V.E, Ballandras-Colas, A, Maskell, D, Locke, J, Kotecha, A, Costa, A, Cherepanov, P. | 登録日 | 2016-10-05 | 公開日 | 2017-01-18 | 最終更新日 | 2018-11-21 | 実験手法 | ELECTRON MICROSCOPY (8.2 Å) | 主引用文献 | A supramolecular assembly mediates lentiviral DNA integration. Science, 355, 2017
|
|
4AU8
| Crystal structure of compound 4a in complex with cdk5, showing an unusual binding mode to the hinge region via a water molecule | 分子名称: | 4-(1,3-benzothiazol-2-yl)thiophene-2-sulfonamide, CYCLIN-DEPENDENT KINASE 5, IMIDAZOLE, ... | 著者 | Malmstrom, J, Viklund, J, Slivo, C, Costa, A, Maudet, M, Sandelin, C, Hiller, G, Olsson, L.L, Aagaard, A, Geschwindner, S, Xue, Y, Vasange, M. | 登録日 | 2012-05-14 | 公開日 | 2013-03-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Synthesis and Structure-Activity Relationship of 4-(1,3-Benzothiazol-2-Yl)-Thiophene-2-Sulfonamides as Cyclin-Dependent Kinase 5 (Cdk5)/P25 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
|
|
4BXO
| Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex | 分子名称: | 5'-D(*GP*AP*TP*GP*AP*TP*GP*CP*TP*GP*CP)-3', 5'-D(*TP*CP*AP*GP*CP*AP*TP*CP*AP*TP*CP)-3', CALCIUM ION, ... | 著者 | Coulthard, R, Deans, A, Swuec, P, Bowles, M, Purkiss, A, Costa, A, West, S, McDonald, N. | 登録日 | 2013-07-15 | 公開日 | 2013-08-28 | 最終更新日 | 2017-06-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Architecture and DNA Recognition Elements of the Fanconi Anemia Fancm-Faap24 Complex. Structure, 21, 2013
|
|
6R85
| Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-glutamate | 分子名称: | 1,2-ETHANEDIOL, GLUTAMIC ACID, Glutamate receptor 3.3,Glutamate receptor 3.3, ... | 著者 | Alfieri, A, Pederzoli, R, Costa, A. | 登録日 | 2019-03-31 | 公開日 | 2020-01-01 | 最終更新日 | 2020-01-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6R8A
| Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-methionine | 分子名称: | Glutamate receptor 3.3,Glutamate receptor 3.3, METHIONINE, SODIUM ION, ... | 著者 | Alfieri, A, Pederzoli, R, Costa, A. | 登録日 | 2019-04-01 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6R88
| Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with glycine | 分子名称: | CHLORIDE ION, GLYCEROL, GLYCINE, ... | 著者 | Alfieri, A, Pederzoli, R, Costa, A. | 登録日 | 2019-04-01 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6R89
| Structure of Arabidopsis thaliana GLR3.3 ligand-binding domain in complex with L-cysteine | 分子名称: | CHLORIDE ION, CYSTEINE, GLYCEROL, ... | 著者 | Alfieri, A, Pederzoli, R, Costa, A. | 登録日 | 2019-04-01 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The structural bases for agonist diversity in anArabidopsis thalianaglutamate receptor-like channel. Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7QHS
| S. cerevisiae CMGE nucleating origin DNA melting | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, ... | 著者 | Lewis, J.S, Sousa, J.S, Costa, A. | 登録日 | 2021-12-14 | 公開日 | 2022-06-15 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Mechanism of replication origin melting nucleated by CMG helicase assembly. Nature, 606, 2022
|
|
6R0C
| Human-D02 Nucleosome Core Particle with biotin-streptavidin label | 分子名称: | DNA (142-MER), Histone H2A type 1, Histone H2B type 1-C/E/F/G/I, ... | 著者 | Pye, V.E, Wilson, M.D, Cherepanov, P, Costa, A. | 登録日 | 2019-03-12 | 公開日 | 2019-09-25 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer. Nat Commun, 10, 2019
|
|
6RAZ
| D. melanogaster CMG-DNA, State 2B | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | 著者 | Eickhoff, P, Martino, F, Costa, A. | 登録日 | 2019-04-08 | 公開日 | 2019-09-18 | 最終更新日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (4.46 Å) | 主引用文献 | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
|
|
6RAW
| D. melanogaster CMG-DNA, State 1A | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | 著者 | Eickhoff, P, Martino, F, Costa, A. | 登録日 | 2019-04-08 | 公開日 | 2019-09-11 | 最終更新日 | 2019-09-18 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
|
|
6RAX
| D. melanogaster CMG-DNA, State 1B | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | 著者 | Eickhoff, P, Martino, F, Costa, A. | 登録日 | 2019-04-08 | 公開日 | 2019-09-11 | 最終更新日 | 2019-09-18 | 実験手法 | ELECTRON MICROSCOPY (3.99 Å) | 主引用文献 | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
|
|
6RAY
| D. melanogaster CMG-DNA, State 2A | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, AT18545p, ... | 著者 | Eickhoff, P, Martino, F, Costa, A. | 登録日 | 2019-04-08 | 公開日 | 2019-09-11 | 最終更新日 | 2019-09-18 | 実験手法 | ELECTRON MICROSCOPY (4.28 Å) | 主引用文献 | Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Rep, 28, 2019
|
|
6YUF
| Cohesin complex with loader gripping DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Cohesin subunit rad21, ... | 著者 | Higashi, T.L, Eickhoff, P, Sousa, J.S, Costa, A, Uhlmann, F. | 登録日 | 2020-04-27 | 公開日 | 2020-08-19 | 最終更新日 | 2020-09-30 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | A Structure-Based Mechanism for DNA Entry into the Cohesin Ring. Mol.Cell, 79, 2020
|
|
7P5Z
| Structure of a DNA-loaded MCM double hexamer engaged with the Dbf4-dependent kinase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 7, ... | 著者 | Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. | 登録日 | 2021-07-15 | 公開日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
|
|
7P30
| 3.0 A resolution structure of a DNA-loaded MCM double hexamer | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (53-MER), ... | 著者 | Greiwe, J.F, Miller, T.C.R, Martino, F, Costa, A. | 登録日 | 2021-07-06 | 公開日 | 2022-02-02 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural mechanism for the selective phosphorylation of DNA-loaded MCM double hexamers by the Dbf4-dependent kinase. Nat.Struct.Mol.Biol., 29, 2022
|
|
6F0L
| S. cerevisiae MCM double hexamer bound to duplex DNA | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DNA (62-MER), DNA replication licensing factor MCM2, ... | 著者 | Abid Ali, F, Pye, V.E, Douglas, M.E, Locke, J, Nans, A, Diffley, J.F.X, Costa, A. | 登録日 | 2017-11-20 | 公開日 | 2017-12-06 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (4.77 Å) | 主引用文献 | Cryo-EM structure of a licensed DNA replication origin. Nat Commun, 8, 2017
|
|
6RQC
| Cryo-EM structure of an MCM loading intermediate | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (88-MER), ... | 著者 | Miller, T.C.R, Locke, J, Costa, A. | 登録日 | 2019-05-15 | 公開日 | 2019-11-20 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM. Nature, 575, 2019
|
|