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8OVB
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BU of 8ovb by Molmil
Human Complement C3b in complex with Trypanosoma brucei ISG65.
Descriptor: Complement C3, Complement C3f fragment, ISG65 G
Authors:Cook, A.D, Higgins, M.K.
Deposit date:2023-04-25
Release date:2024-02-14
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular mechanism of complement inhibition by the trypanosome receptor ISG65.
Elife, 12, 2024
7NB8
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BU of 7nb8 by Molmil
Plasmodium falciparum kinesin-5 motor domain without nucleotide, complexed with 14 protofilament microtubule.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin-5, MAGNESIUM ION, ...
Authors:Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.
J.Biol.Chem., 297, 2021
7NBA
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BU of 7nba by Molmil
Plasmodium falciparum kinesin-5 motor domain bound to AMPPNP, complexed with 14 protofilament microtubule.
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin motor domain-containing protein,Kinesin motor domain-containing protein, MAGNESIUM ION, ...
Authors:Cook, A.D, Roberts, A, Atherton, J, Tewari, R, Topf, M, Moores, C.A.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2021-10-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.
J.Biol.Chem., 297, 2021
7PI6
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BU of 7pi6 by Molmil
Trypanosoma brucei ISG65 bound to human complement C3d
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 65 kDa invariant surface glycoprotein, Complement C3dg fragment, ...
Authors:Cook, A.D, Higgins, M.K.
Deposit date:2021-08-19
Release date:2022-07-27
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Nat Commun, 13, 2022
7Z2A
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BU of 7z2a by Molmil
P. berghei kinesin-8B motor domain in no nucleotide state bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-10-19
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z2C
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BU of 7z2c by Molmil
P. falciparum kinesin-8B motor domain in no nucleotide bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-10-19
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
7Z2B
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BU of 7z2b by Molmil
P. berghei kinesin-8B motor domain in AMPPNP state bound to tubulin dimer
Descriptor: Detyrosinated tubulin alpha-1B chain, GUANOSINE-5'-TRIPHOSPHATE, Kinesin-8, ...
Authors:Liu, T, Shilliday, F, Cook, A.D, Moores, C.A.
Deposit date:2022-02-26
Release date:2022-11-16
Last modified:2022-11-30
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Mechanochemical tuning of a kinesin motor essential for malaria parasite transmission.
Nat Commun, 13, 2022
6TIW
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BU of 6tiw by Molmil
Human kinesin-5 motor domain in the GSK state bound to microtubules (Conformation 2)
Descriptor: 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-11-22
Release date:2020-03-04
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
6TA4
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BU of 6ta4 by Molmil
Human kinesin-5 motor domain in the AMPPNP state bound to microtubules
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A.P, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-10-29
Release date:2020-03-04
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
6TA3
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BU of 6ta3 by Molmil
Human kinesin-5 motor domain in the GSK-1 state bound to microtubules (Conformation 1)
Descriptor: 6-[4-(trifluoromethyl)phenyl]-3,4-dihydro-1~{H}-quinolin-2-one, Kinesin-like protein KIF11, MAGNESIUM ION, ...
Authors:Pena, A, Sweeney, A, Cook, A.D, Moores, C.A, Topf, M.
Deposit date:2019-10-29
Release date:2020-04-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of Microtubule-Trapped Human Kinesin-5 and Its Mechanism of Inhibition Revealed Using Cryoelectron Microscopy.
Structure, 28, 2020
6RF8
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BU of 6rf8 by Molmil
Cryo-EM structure of the N-terminal DC repeat (NDC) of NDC-NDC chimera (human sequence) bound to 13-protofilament GDP-microtubule
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Manka, S.W.
Deposit date:2019-04-12
Release date:2020-04-15
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:A microtubule RELION-based pipeline for cryo-EM image processing.
J.Struct.Biol., 209, 2020
6QUS
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BU of 6qus by Molmil
HsCKK (human CAMSAP1) decorated 13pf taxol-GDP microtubule
Descriptor: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-02-28
Release date:2019-11-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QVJ
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BU of 6qvj by Molmil
HsCKK (human CAMSAP1) decorated 14pf taxol-GDP microtubule
Descriptor: Calmodulin-regulated spectrin-associated protein 1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-03-02
Release date:2019-11-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QUY
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BU of 6quy by Molmil
NgCKK (N.Gruberi CKK) decorated 13pf taxol-GDP microtubule
Descriptor: CKK domain protein, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-02-28
Release date:2019-11-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
6QVE
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BU of 6qve by Molmil
NgCKK (Naegleria Gruberi CKK) decorated 14pf taxol-GDP microtubule
Descriptor: Beta1-tubulin, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Atherton, J.M, Luo, Y, Xiang, S, Yang, C, Jiang, K, Stangier, M, Vemu, A, Cook, A, Wang, S, Roll-Mecak, A, Steinmetz, M.O, Akhmanova, A, Baldus, M, Moores, C.A.
Deposit date:2019-03-01
Release date:2019-11-27
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural determinants of microtubule minus end preference in CAMSAP CKK domains.
Nat Commun, 10, 2019
7PJF
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BU of 7pjf by Molmil
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
Descriptor: Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O.
Deposit date:2021-08-24
Release date:2021-09-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.862 Å)
Cite:Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021
7PJE
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BU of 7pje by Molmil
Inhibiting parasite proliferation using a rationally designed anti-tubulin agent
Descriptor: Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O.
Deposit date:2021-08-24
Release date:2021-09-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibiting parasite proliferation using a rationally designed anti-tubulin agent.
Embo Mol Med, 13, 2021

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