6X67
| Cryo-EM structure of piggyBac transposase strand transfer complex (STC) | Descriptor: | CALCIUM ION, DNA (37-MER), DNA (47-MER), ... | Authors: | Chen, Q, Hickman, A.B, Dyda, F. | Deposit date: | 2020-05-27 | Release date: | 2020-07-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Structural basis of seamless excision and specific targeting by piggyBac transposase Nat Commun, 11, 2020
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2GEB
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5WPT
| Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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6E5V
| human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG) | Descriptor: | 4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid, CHLORIDE ION, Metabotropic glutamate receptor 8 | Authors: | Chen, Q, Ho, J.D, Ashok, S, Vargas, M.C, Wang, J, Atwell, S, Bures, M, Schkeryantz, J.M, Monn, J.A, Hao, J. | Deposit date: | 2018-07-23 | Release date: | 2018-11-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8Receptor. J. Med. Chem., 61, 2018
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8AE3
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-07-12 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8ADZ
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-07-12 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (6.7 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8AE0
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 3 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-07-12 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8ADY
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-07-12 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8AE2
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-07-12 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (8.5 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8BPG
| FcMR binding at subunit Fcu3 of IgM pentamer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-11-16 | Release date: | 2023-04-12 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for Fc receptor recognition of immunoglobulin M. Nat.Struct.Mol.Biol., 30, 2023
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8BPF
| FcMR binding at subunit Fcu1 of IgM pentamer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-11-16 | Release date: | 2023-04-12 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for Fc receptor recognition of immunoglobulin M. Nat.Struct.Mol.Biol., 30, 2023
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8BPE
| 8:1 binding of FcMR on IgM pentameric core | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fas apoptotic inhibitory molecule 3, ... | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2022-11-16 | Release date: | 2023-04-12 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Structural basis for Fc receptor recognition of immunoglobulin M. Nat.Struct.Mol.Biol., 30, 2023
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6LDU
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6LE7
| Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 2 | Descriptor: | (4R)-3-(2-hydroxyphenyl)-4-(3-methoxy-4-propoxy-phenyl)-5-(pyridin-3-ylmethyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one, Probable endochitinase | Authors: | Chen, Q, Yang, Q, Zhou, Y. | Deposit date: | 2019-11-24 | Release date: | 2021-05-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.85753441 Å) | Cite: | Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 2 To Be Published
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6LE8
| Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 1 | Descriptor: | (4R)-4-(4-ethoxyphenyl)-3-(2-hydroxyphenyl)-5-(pyridin-3-ylmethyl)-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | Authors: | Chen, Q, Yang, Q, Zhou, Y. | Deposit date: | 2019-11-24 | Release date: | 2021-05-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.39909327 Å) | Cite: | Crystal structure of nematode family I chitinase,CeCht1, in complex with dihydropyrrolopyrazol-6-one derivate 1 To Be Published
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7QDO
| Cryo-EM structure of human monomeric IgM-Fc | Descriptor: | Isoform 2 of Immunoglobulin heavy constant mu | Authors: | Chen, Q, Rosenthal, P, Tolar, P. | Deposit date: | 2021-11-27 | Release date: | 2022-10-26 | Last modified: | 2022-11-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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1R3U
| Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis | Descriptor: | ACETATE ION, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION | Authors: | Chen, Q, Liang, Y.H, Gu, X.C, Luo, M, Su, X.D. | Deposit date: | 2003-10-03 | Release date: | 2004-10-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis To be published
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1YFZ
| Novel IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis | Descriptor: | ACETATE ION, Hypoxanthine-guanine phosphoribosyltransferase, INOSINIC ACID, ... | Authors: | Chen, Q, Liang, Y, Su, X, Gu, X, Zheng, X, Luo, M. | Deposit date: | 2005-01-04 | Release date: | 2005-05-10 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Alternative IMP Binding in Feedback Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferase from Thermoanaerobacter tengcongensis. J.Mol.Biol., 348, 2005
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2AIN
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6X68
| Cryo-EM structure of piggyBac transposase synaptic complex with hairpin DNA (SNHP) | Descriptor: | CALCIUM ION, Transposase, ZINC ION, ... | Authors: | Chen, Q, Hickman, A.B, Dyda, F. | Deposit date: | 2020-05-27 | Release date: | 2020-07-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | Structural basis of seamless excision and specific targeting by piggyBac transposase Nat Commun, 11, 2020
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4Z90
| ELIC bound with the anesthetic isoflurane in the resting state | Descriptor: | (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Gamma-aminobutyric-acid receptor subunit beta-1 | Authors: | Chen, Q, Kinde, M, Arjunan, P, Cohen, A, Xu, Y, Tang, P. | Deposit date: | 2015-04-09 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC. Sci Rep, 5, 2015
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4Z91
| ELIC cocrystallized with isofluorane in a desensitized state | Descriptor: | (2R)-2-chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane, 1.7.6 3-bromanylpropan-1-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Chen, Q, Kinde, M.N, Arjunan, P, Cohen, A, Xu, Y, Tang, P. | Deposit date: | 2015-04-09 | Release date: | 2015-09-16 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3915 Å) | Cite: | Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC. Sci Rep, 5, 2015
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7S03
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7EPW
| Crystal structure of monooxygenase Tet(X4) with tigecycline | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, TIGECYCLINE | Authors: | Cheng, Q, Chen, S. | Deposit date: | 2021-04-28 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.23 Å) | Cite: | Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol., 19, 2021
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7EPV
| Crystal structure of tigecycline degrading monooxygenase Tet(X4) | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, Flavin-dependent monooxygenase, GLYCEROL | Authors: | Cheng, Q, Chen, S. | Deposit date: | 2021-04-27 | Release date: | 2021-11-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. Bmc Biol., 19, 2021
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