6D8C
 
 | | Cryo-EM structure of FLNaABD E254K bound to phalloidin-stabilized F-actin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | | 著者 | Iwamoto, D.V, Huehn, A.R, Simon, B, Huet-Calderwood, C, Baldassarre, M, Sindelar, C.V, Calderwood, D.A. | | 登録日 | 2018-04-26 | | 公開日 | 2018-09-19 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural basis of the filamin A actin-binding domain interaction with F-actin.
Nat. Struct. Mol. Biol., 25, 2018
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3F6Q
 | | Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain | | 分子名称: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | | 著者 | Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2008-11-06 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The structural basis of integrin-linked kinase-PINCH interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
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4EDM
 | | Crystal structure of beta-parvin CH2 domain | | 分子名称: | 1,2-ETHANEDIOL, Beta-parvin | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4HI9
 | | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974 | | 分子名称: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | | 著者 | Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-10-11 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.203 Å) | | 主引用文献 | 1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974
To be Published
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4HI8
 | | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800 | | 分子名称: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ... | | 著者 | Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-10-11 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.203 Å) | | 主引用文献 | Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
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3IXE
 | | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase | | 分子名称: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION | | 著者 | Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A. | | 登録日 | 2009-09-03 | | 公開日 | 2009-12-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
J.Struct.Biol., 170, 2010
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4BBK
 | | Structural and functional characterisation of the kindlin-1 pleckstrin homology domain | | 分子名称: | FERMITIN FAMILY HOMOLOG 1, GLYCEROL | | 著者 | Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C. | | 登録日 | 2012-09-25 | | 公開日 | 2012-11-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
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4DX9
 | | ICAP1 in complex with integrin beta 1 cytoplasmic tail | | 分子名称: | Integrin beta-1, Integrin beta-1-binding protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2020-09-02 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4DX8
 | | ICAP1 in complex with KRIT1 N-terminus | | 分子名称: | BROMIDE ION, Integrin beta-1-binding protein 1, Krev interaction trapped protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4EDL
 | | Crystal structure of beta-parvin CH2 domain | | 分子名称: | 1,2-ETHANEDIOL, Beta-parvin | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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4EDN
 | | Crystal structure of beta-parvin CH2 domain in complex with paxillin LD1 motif | | 分子名称: | Beta-parvin, Paxillin, SULFATE ION | | 著者 | Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-03-27 | | 公開日 | 2012-08-08 | | 最終更新日 | 2013-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
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1MK7
 | | CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA | | 分子名称: | Integrin Beta3, TALIN | | 著者 | Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | 登録日 | 2002-08-28 | | 公開日 | 2003-01-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
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1MIX
 | | Crystal structure of a FERM domain of Talin | | 分子名称: | Talin | | 著者 | Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | 登録日 | 2002-08-23 | | 公開日 | 2003-01-28 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
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1MK9
 | | CRYSTAL STRUCTURE OF AN INTEGRIN BETA3-TALIN CHIMERA | | 分子名称: | Integrin Beta3, TALIN | | 著者 | Garcia-Alvarez, B, De Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | 登録日 | 2002-08-28 | | 公開日 | 2003-01-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural Determinants of Integrin Recognition by Talin
Mol.Cell, 11, 2003
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1MIZ
 | | Crystal structure of an integrin beta3-talin chimera | | 分子名称: | TALIN, integrin beta3 | | 著者 | Garcia-Alvarez, B, de Pereda, J.M, Calderwood, D.A, Ulmer, T.S, Critchley, D, Campbell, I.D, Ginsberg, M.H, Liddington, R.C. | | 登録日 | 2002-08-23 | | 公開日 | 2003-01-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural determinants of integrin recognition by talin
Mol.Cell, 11, 2003
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7LO0
 | | Structure of human ASF1a in complex with a TLK2 peptide | | 分子名称: | Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2 | | 著者 | Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J. | | 登録日 | 2021-02-08 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
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7LNY
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2W0P
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4TVQ
 | | CCM3 in complex with CCM2 LD-like motif | | 分子名称: | Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein | | 著者 | Li, X, Zhang, R, Fisher, O.S, Boggon, T.J. | | 登録日 | 2014-06-27 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
J.Cell Biol., 208, 2015
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7S46
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7S48
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7S47
 | | Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E) | | 分子名称: | Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2021-09-08 | | 公開日 | 2022-11-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Commun Biol, 5, 2022
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4KS8
 | | PAK6 kinase domain in complex with sunitinib | | 分子名称: | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, Serine/threonine-protein kinase PAK 6 | | 著者 | Gao, J, Boggon, T.J. | | 登録日 | 2013-05-17 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6.
Plos One, 8, 2013
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4KS7
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2BRQ
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