8DDC
 
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8DDD
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1LZZ
 | | Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-ISOPROPYL-N'-HYDROXYGUANIDINE, ... | | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | | 登録日 | 2002-06-11 | | 公開日 | 2002-11-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
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1LZX
 | | Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-OMEGA-HYDROXY-L-ARGININE, ... | | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | | 登録日 | 2002-06-11 | | 公開日 | 2002-11-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
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1M00
 | | Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-BUTYL-N'-HYDROXYGUANIDINE, ... | | 著者 | Li, H, Shimizu, H, Flinspach, M, Jamal, J, Yang, W, Xian, M, Cai, T, Wen, E.Z, Jia, Q, Wang, P.G, Poulos, T.L. | | 登録日 | 2002-06-11 | | 公開日 | 2002-11-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The Novel Binding Mode of N-Alkyl-N'-Hydroxyguanidine to Neuronal Nitric Oxide
Synthase Provides Mechanistic Insights into NO Biosynthesis
Biochemistry, 41, 2002
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2ZJG
 | | Crystal structural of mouse kynurenine aminotransferase III | | 分子名称: | GLYCEROL, Kynurenine-oxoglutarate transaminase 3 | | 著者 | Han, Q, Cai, T, Tagle, D.A, Robinson, H, Li, J. | | 登録日 | 2008-03-07 | | 公開日 | 2009-01-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural and functional characterization of mouse kynurenine aminotransferase III
To be Published
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3PD6
 | | Crystal structure of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV | | 分子名称: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, ... | | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2010-10-22 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
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3PDB
 | | Crystal structure of mouse mitochondrial aspartate aminotransferase in complex with oxaloacetic acid | | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase, mitochondrial, ... | | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2010-10-22 | | 公開日 | 2010-11-10 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Biochemical and structural characterization of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV.
Biosci.Rep., 31, 2011
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3E2Y
 | | Crystal structure of mouse kynurenine aminotransferase III in complex with glutamine | | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLUTAMINE, GLYCEROL, ... | | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2008-08-06 | | 公開日 | 2008-12-30 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
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3E2Z
 | | Crystal structure of mouse kynurenine aminotransferase III in complex with kynurenine | | 分子名称: | (2S)-2-amino-4-(2-aminophenyl)-4-oxobutanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, GLYCEROL, ... | | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2008-08-06 | | 公開日 | 2008-12-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
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3E2F
 | | Crystal structure of mouse kynurenine aminotransferase III, PLP-bound form | | 分子名称: | GLYCEROL, Kynurenine-oxoglutarate transaminase 3 | | 著者 | Han, Q, Robinson, R, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2008-08-05 | | 公開日 | 2008-12-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Correction for Han et al., "Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III".
Mol. Cell. Biol., 38, 2018
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4MM0
 | | Crystal Structure Analysis of the Putative Thioether Synthase SgvP Involved in the Tailoring Step of Griseoviridin | | 分子名称: | P450-like monooxygenase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Zhang, H, Huang, L, Yi, M, Cai, T, Zhang, H. | | 登録日 | 2013-09-07 | | 公開日 | 2014-09-17 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Analysis of SgvP: a Putative Thioether Synthase Involved in the Tailoring Step of Griseoviridin
To be Published
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3FVS
 | | Human Kynurenine Aminotransferase I in complex with Glycerol | | 分子名称: | GLYCEROL, Kynurenine--oxoglutarate transaminase 1, SODIUM ION | | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2009-01-16 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
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3FVU
 | | Crystal Structure of Human Kynurenine Aminotransferase I in Complex with Indole-3-acetic Acid | | 分子名称: | 1H-INDOL-3-YLACETIC ACID, GLYCEROL, Kynurenine--oxoglutarate transaminase 1, ... | | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2009-01-16 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
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3FVX
 | | Human kynurenine aminotransferase I in complex with tris | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Kynurenine--oxoglutarate transaminase 1, SODIUM ION | | 著者 | Han, Q, Robinson, H, Cai, T, Tagle, D.A, Li, J. | | 登録日 | 2009-01-16 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural insight into the inhibition of human kynurenine aminotransferase I/glutamine transaminase K
J.Med.Chem., 52, 2009
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2P01
 | | The structure of receptor-associated protein(RAP) | | 分子名称: | Alpha-2-macroglobulin receptor-associated protein | | 著者 | Lee, D, Walsh, J.D, Migliorini, M, Yu, P, Cai, T, Schwieters, C.D, Krueger, S, Strickland, D.K, Wang, Y.X. | | 登録日 | 2007-02-28 | | 公開日 | 2007-08-21 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of receptor-associated protein (RAP).
Protein Sci., 16, 2007
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2P03
 | | The structure of receptor-associated protein(RAP) | | 分子名称: | Alpha-2-macroglobulin receptor-associated protein | | 著者 | Lee, D, Walsh, J.D, Migliorini, M, Yu, P, Cai, T, Schwieters, C.D, Krueger, S, Strickland, D.K, Wang, Y.X. | | 登録日 | 2007-02-28 | | 公開日 | 2007-08-21 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of receptor-associated protein (RAP).
Protein Sci., 16, 2007
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3DC1
 | | Crystal structure of kynurenine aminotransferase II complex with alpha-ketoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, GLYCEROL, Kynurenine/alpha-aminoadipate aminotransferase mitochondrial | | 著者 | Han, Q, Cai, T, Tagle, D.A, Robinson, H, Li, J. | | 登録日 | 2008-06-03 | | 公開日 | 2008-07-29 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II
Biosci.Rep., 28, 2008
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3QAQ
 | | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 1 | | 分子名称: | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, [(4-{2-[(3-hydroxyphenyl)amino]-1H-benzimidazol-1-yl}-1,3,5-triazin-2-yl)amino]acetonitrile | | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | | 登録日 | 2011-01-11 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg.Med.Chem.Lett., 21, 2011
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3QAR
 | | Crystal structure of PI3K-gamma in complex with triazine-benzimidazole 32 | | 分子名称: | 1-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-3-yl)-1H-benzimidazol-2-amine, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | | 登録日 | 2011-01-11 | | 公開日 | 2011-03-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Bioorg.Med.Chem.Lett., 21, 2011
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8DPX
 | | Preligand association structure of DR5 | | 分子名称: | Tumor necrosis factor receptor superfamily member 10B | | 著者 | Du, G, Zhao, L, Chou, J.J. | | 登録日 | 2022-07-17 | | 公開日 | 2023-02-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation.
Cell Res., 33, 2023
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4FHJ
 | | Crystal Structure of PI3K-gamma in Complex with Imidazopyridine 2 | | 分子名称: | 3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-N-(1H-pyrazol-5-yl)imidazo[1,2-a]pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Shaffer, P.L, Tang, J, Yakowec, P. | | 登録日 | 2012-06-06 | | 公開日 | 2012-07-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4FHK
 | | Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e | | 分子名称: | 3-[2-methyl-6-(pyrazin-2-ylamino)pyrimidin-4-yl]-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Shaffer, P.L, Tang, J, Yakowec, P. | | 登録日 | 2012-06-06 | | 公開日 | 2013-04-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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3HLM
 | | Crystal Structure of Mouse Mitochondrial Aspartate Aminotransferase/Kynurenine Aminotransferase IV | | 分子名称: | Aspartate aminotransferase, mitochondrial, GLYCEROL | | 著者 | Han, Q, Robinson, H, Li, J. | | 登録日 | 2009-05-27 | | 公開日 | 2010-06-02 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure, expression, and function of kynurenine aminotransferases in human and rodent brains.
Cell.Mol.Life Sci., 67, 2010
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5VEQ
 | | MOUSE KYNURENINE AMINOTRANSFERASE III, RE-REFINEMENT OF THE PDB STRUCTURE 3E2Y | | 分子名称: | 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Wlodawer, A, Dauter, Z, Minor, W, Stanfield, R, Porebski, P, Jaskolski, M, Pozharski, E, Weichenberger, C.X, Rupp, B. | | 登録日 | 2017-04-05 | | 公開日 | 2017-11-29 | | 最終更新日 | 2022-04-13 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Detect, correct, retract: How to manage incorrect structural models.
FEBS J., 285, 2018
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