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4FHK

Crystal Structure of PI3K-gamma in Complex with Imidazopyridazine 19e

Summary for 4FHK
Entry DOI10.2210/pdb4fhk/pdb
DescriptorPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 3-[2-methyl-6-(pyrazin-2-ylamino)pyrimidin-4-yl]-N-(1H-pyrazol-3-yl)imidazo[1,2-b]pyridazin-2-amine, ... (4 entities in total)
Functional Keywordsp110, kinase, atp-binding, p84, p101, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P48736
Total number of polymer chains1
Total formula weight110593.69
Authors
Shaffer, P.L.,Tang, J.,Yakowec, P. (deposition date: 2012-06-06, release date: 2013-04-10, Last modification date: 2023-09-13)
Primary citationPeterson, E.A.,Boezio, A.A.,Andrews, P.S.,Boezio, C.M.,Bush, T.L.,Cheng, A.C.,Choquette, D.,Coats, J.R.,Colletti, A.E.,Copeland, K.W.,DuPont, M.,Graceffa, R.,Grubinska, B.,Kim, J.L.,Lewis, R.T.,Liu, J.,Mullady, E.L.,Potashman, M.H.,Romero, K.,Shaffer, P.L.,Stanton, M.K.,Stellwagen, J.C.,Teffera, Y.,Yi, S.,Cai, T.,La, D.S.
Discovery and optimization of potent and selective imidazopyridine and imidazopyridazine mTOR inhibitors.
Bioorg.Med.Chem.Lett., 22:4967-4974, 2012
Cited by
PubMed: 22765895
DOI: 10.1016/j.bmcl.2012.06.033
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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