2WWV
| NMR structure of the IIAchitobiose-IIBchitobiose complex of the N,N'- diacetylchitoboise brance of the E. coli phosphotransferase system. | Descriptor: | N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT, N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT | Authors: | Sang, Y.S, Cai, M, Clore, G.M. | Deposit date: | 2009-10-29 | Release date: | 2009-12-08 | Last modified: | 2019-10-16 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Iiachitobose-Iibchitobiose Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia Coli Phosphotransfer System J.Biol.Chem., 285, 2010
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2WY2
| NMR structure of the IIAchitobiose-IIBchitobiose phosphoryl transition state complex of the N,N'-diacetylchitoboise brance of the E. coli phosphotransferase system. | Descriptor: | N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT, N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT, PHOSPHITE ION | Authors: | Sang, Y.S, Cai, M, Clore, G.M. | Deposit date: | 2009-11-11 | Release date: | 2009-12-08 | Last modified: | 2019-10-16 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Iiachitobose-Iibchitobiose Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia Coli Phosphotransfer System J.Biol.Chem., 285, 2010
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1VKR
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1VRV
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1ZHS
| Crystal structure of MVL bound to Man3GlcNAc2 | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Williams, D.C, Lee, J.Y, Cai, M, Bewley, C.A, Clore, G.M. | Deposit date: | 2005-04-26 | Release date: | 2005-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structures of the HIV-1 Inhibitory Cyanobacterial Protein MVL Free and Bound to Man3GlcNAc2: STRUCTURAL BASIS FOR SPECIFICITY AND HIGH-AFFINITY BINDING TO THE CORE PENTASACCHARIDE FROM N-LINKED OLIGOMANNOSIDE. J.Biol.Chem., 280, 2005
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1ZHQ
| Crystal structure of apo MVL | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, mannan-binding lectin | Authors: | Williams, D.C, Lee, J.Y, Cai, M, Bewley, C.A, Clore, G.M. | Deposit date: | 2005-04-26 | Release date: | 2005-06-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structures of the HIV-1 Inhibitory Cyanobacterial Protein MVL Free and Bound to Man3GlcNAc2: STRUCTURAL BASIS FOR SPECIFICITY AND HIGH-AFFINITY BINDING TO THE CORE PENTASACCHARIDE FROM N-LINKED OLIGOMANNOSIDE. J.Biol.Chem., 280, 2005
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6FCE
| NMR ensemble of Macrocyclic Peptidomimetic Containing Constrained a,a-dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors | Descriptor: | ACP-HIS-DPHE-ARG-TRP-ASP-NH2 | Authors: | Brancaccio, D, Carotenuto, A, Grieco, P, Merlino, F, Zhou, Y, Cai, M, Yousif, A.M, Di Maro, S, Novellino, E, Hruby, V.J. | Deposit date: | 2017-12-20 | Release date: | 2018-04-25 | Last modified: | 2018-05-23 | Method: | SOLUTION NMR | Cite: | Development of Macrocyclic Peptidomimetics Containing Constrained alpha , alpha-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. J. Med. Chem., 61, 2018
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2LRL
| Solution Structures of the IIA(Chitobiose)-HPr complex of the N,N'-Diacetylchitobiose Branch of the Escherichia coli Phosphotransferase System | Descriptor: | N,N'-diacetylchitobiose-specific phosphotransferase enzyme IIA component, PHOSPHITE ION, Phosphocarrier protein HPr | Authors: | Jung, Y, Cai, M, Clore, M. | Deposit date: | 2012-04-06 | Release date: | 2012-05-16 | Last modified: | 2012-07-25 | Method: | SOLUTION NMR | Cite: | Solution Structure of the IIAChitobiose-HPr Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia coli Phosphotransferase System. J.Biol.Chem., 287, 2012
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1C9Q
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7NA4
| HDM2 in complex with compound 63 | Descriptor: | 3-[4-(5-chloropyridin-3-yl)-2-[(R)-cyclopropyl(ethoxy)methyl]-3-{(1R)-1-[(1r,4R)-4-methylcyclohexyl]ethyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one, CHLORIDE ION, GLYCEROL, ... | Authors: | Scapin, G. | Deposit date: | 2021-06-19 | Release date: | 2021-11-10 | Last modified: | 2021-11-24 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
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7NA2
| HDM2 in complex with compound 56 | Descriptor: | 3-[4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-{[(1r,4R)-4-methylcyclohexyl]methyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one, Isoform 11 of E3 ubiquitin-protein ligase Mdm2 | Authors: | Scapin, G. | Deposit date: | 2021-06-19 | Release date: | 2021-11-10 | Last modified: | 2021-11-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
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7NA1
| HDM2 in complex with compound 2 | Descriptor: | 8-(1-benzothiophen-5-yl)-7-[(4-chlorophenyl)methyl]-6-{[(1R)-1-cyclopropylethyl]amino}-7H-purine-2-carboxylic acid, CITRIC ACID, E3 ubiquitin-protein ligase Mdm2, ... | Authors: | Scapin, G. | Deposit date: | 2021-06-19 | Release date: | 2021-11-10 | Last modified: | 2021-11-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
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7NA3
| HDM2 in complex with compound 62 | Descriptor: | 3-[4-(5-chloropyridin-3-yl)-2-[(2S)-1-methoxypropan-2-yl]-3-{(1R)-1-[(1r,4R)-4-methylcyclohexyl]ethyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one, Isoform 11 of E3 ubiquitin-protein ligase Mdm2, SULFATE ION | Authors: | Scapin, G. | Deposit date: | 2021-06-19 | Release date: | 2021-11-10 | Last modified: | 2021-11-24 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction. J.Med.Chem., 64, 2021
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2EZP
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2EZS
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2EZR
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2EZO
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2EZQ
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1QCE
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1VRC
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1VSQ
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2N7O
| NMR Structure of Peptide PG-990 in DPC micelles | Descriptor: | Peptide PG-990 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-16 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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2N7T
| NMR structure of Peptide PG-992 in DPC micelles | Descriptor: | Peptide PG-992 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-17 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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2N7N
| NMR structure of Peptide PG-989 in DPC micelles | Descriptor: | Peptide PG-989 | Authors: | Carotenuto, A, Merlino, F, Chai, M, Brancaccio, D, Yousif, A, Novellino, E, Hruby, V, Grieco, P. | Deposit date: | 2015-09-16 | Release date: | 2015-12-16 | Last modified: | 2017-10-11 | Method: | SOLUTION NMR | Cite: | Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor. J.Med.Chem., 58, 2015
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1O4X
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