7NA3

HDM2 in complex with compound 62

Summary for 7NA3

• Entry DOI: 10.2210/pdb7na3/pdb
• Descriptor: Isoform 11 of E3 ubiquitin-protein ligase Mdm2, 3-[4-(5-chloropyridin-3-yl)-2-[(2S)-1-methoxypropan-2-yl]-3-{(1R)-1-[(1r,4R)-4-methylcyclohexyl]ethyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one, SULFATE ION, ... (4 entities in total)
• Functional Keywords: p53, drug design, protein-protein interactions, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13487.67

Authors

Scapin, G. (deposition date: 2021-06-19, release date: 2021-11-10, Last modification date: 2021-11-24)

• Primary citation: Reutershan, M.H.,Machacek, M.R.,Altman, M.D.,Bogen, S.,Cai, M.,Cammarano, C.,Chen, D.,Christopher, M.,Cryan, J.,Daublain, P.,Fradera, X.,Geda, P.,Goldenblatt, P.,Hill, A.D.,Kemper, R.A.,Kutilek, V.,Li, C.,Martinez, M.,McCoy, M.,Nair, L.,Pan, W.,Thompson, C.F.,Scapin, G.,Shizuka, M.,Spatz, M.L.,Steinhuebel, D.,Sun, B.,Voss, M.E.,Wang, X.,Yang, L.,Yeh, T.C.,Dussault, I.,Marshall, C.G.,Trotter, B.W.; Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.; J.Med.Chem., 64:16213-16241, 2021; PubMed: 34714078; DOI: 10.1021/acs.jmedchem.1c01524

Experimental method

X-RAY DIFFRACTION (2.21 Å)