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7NA2

HDM2 in complex with compound 56

Summary for 7NA2
Entry DOI10.2210/pdb7na2/pdb
DescriptorIsoform 11 of E3 ubiquitin-protein ligase Mdm2, 3-[4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-{[(1r,4R)-4-methylcyclohexyl]methyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one (3 entities in total)
Functional Keywordsp53, drug design, protein-protein interactions, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight26284.91
Authors
Scapin, G. (deposition date: 2021-06-19, release date: 2021-11-10, Last modification date: 2021-11-24)
Primary citationReutershan, M.H.,Machacek, M.R.,Altman, M.D.,Bogen, S.,Cai, M.,Cammarano, C.,Chen, D.,Christopher, M.,Cryan, J.,Daublain, P.,Fradera, X.,Geda, P.,Goldenblatt, P.,Hill, A.D.,Kemper, R.A.,Kutilek, V.,Li, C.,Martinez, M.,McCoy, M.,Nair, L.,Pan, W.,Thompson, C.F.,Scapin, G.,Shizuka, M.,Spatz, M.L.,Steinhuebel, D.,Sun, B.,Voss, M.E.,Wang, X.,Yang, L.,Yeh, T.C.,Dussault, I.,Marshall, C.G.,Trotter, B.W.
Discovery of MK-4688 : an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J.Med.Chem., 64:16213-16241, 2021
Cited by
PubMed: 34714078
DOI: 10.1021/acs.jmedchem.1c01524
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

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