7NA2
HDM2 in complex with compound 56
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Isoform 11 of E3 ubiquitin-protein ligase Mdm2 | polymer | 110 | 12592.4 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (A, B) | 3-[4-(5-chloropyridin-3-yl)-2-[(4aR,7aR)-hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl]-3-{[(1r,4R)-4-methylcyclohexyl]methyl}-3H-imidazo[4,5-c]pyridin-6-yl]-1,2,4-oxadiazol-5(4H)-one | non-polymer | 550.1 | 2 | Chemie (1I0) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 25184.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1100.1 | |
| All* | Total formula weight | 26284.9 |
