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5E73
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Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH47
分子名称: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide
著者Lolli, G, Spiliotopoulos, D, Unzue, A, Nevado, C, Caflisch, A.
登録日2015-10-11
公開日2015-10-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
5E74
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Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH50
分子名称: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)-3-(trifluoromethyl)benzamide
著者Lolli, G, Spiliotopoulos, D, Dolbois, A, Nevado, C, Caflisch, A.
登録日2015-10-11
公開日2015-10-21
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.783 Å)
主引用文献The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J. Med. Chem., 59, 2016
5EWD
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Crystal structure of the human BRPF1 bromodomain in complex with SEED18
分子名称: 4-phenylpyridine, NITRATE ION, Peregrin
著者Zhu, J, Caflisch, A.
登録日2015-11-20
公開日2016-05-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Twenty Crystal Structures of Bromodomain and PHD Finger Containing Protein 1 (BRPF1)/Ligand Complexes Reveal Conserved Binding Motifs and Rare Interactions.
J.Med.Chem., 59, 2016
5MPK
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Crystal structure of CREBBP bromodomain complexed with DK19
分子名称: CREB-binding protein, ~{N}-(5-ethanoyl-2-ethoxy-phenyl)-3-(2~{H}-1,2,3,4-tetrazol-5-yl)-5-(1,3-thiazol-4-yl)benzamide
著者Zhu, J, Caflisch, A.
登録日2016-12-16
公開日2018-01-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5MMG
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Crystal structure of CREBBP bromodomain complexed with UT07C
分子名称: 1-[4-ethoxy-3-[(1-methylsulfonylindol-6-yl)amino]phenyl]ethanone, CREB-binding protein
著者Zhu, J, Caflisch, A.
登録日2016-12-09
公開日2017-12-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5MPN
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Crystal structure of CREBBP bromodomain complexed with FA26
分子名称: 1,2-ETHANEDIOL, 1-[4-ethoxy-3-[3-(2~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]ethanone, CREB-binding protein
著者Zhu, J, Caflisch, A.
登録日2016-12-16
公開日2018-01-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5D7X
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Crystal structure of the human BRPF1 bromodomain in complex with XZ08
分子名称: 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one, NITRATE ION, Peregrin
著者Zhu, J, Caflisch, A.
登録日2015-08-14
公開日2016-05-25
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.
J.Med.Chem., 59, 2016
6FR0
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Crystal structure of CREBBP bromodomain complexd with PB08
分子名称: CREB-binding protein, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(2-ethyl-5-methyl-3-oxidanylidene-1,2-oxazol-4-yl)phenyl]furan-2-carboxamide
著者Zhu, J, Caflisch, A.
登録日2018-02-15
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
6FRF
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Crystal structure of CREBBP bromodomain complexd with PA10
分子名称: CREB-binding protein, ~{N}-[3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-(5-ethanoyl-2-ethoxy-phenyl)phenyl]furan-2-carboxamide
著者Zhu, J, Caflisch, A.
登録日2018-02-15
公開日2018-08-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules.
ACS Med Chem Lett, 9, 2018
5F36
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Crystal structure of the bromodomain of human ATAD2 in complex with Compound A12
分子名称: ATPase family AAA domain-containing protein 2, CHLORIDE ION, SULFATE ION, ...
著者Dong, J, Caflisch, A.
登録日2015-12-02
公開日2016-12-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers.
Acs Med.Chem.Lett., 11, 2020
6YM2
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Crystal structure of YTHDC1 with compound ADO_AC_25
分子名称: SULFATE ION, YTHDC1, ~{N},9-dimethylpurin-6-amine
著者Bedi, R.K, Li, Y, Dolbois, A, Wiedmer, L, Caflisch, A.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of YTHDC1 with compound ADO_AC_25
To Be Published
6FGL
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Crystal Structure of BAZ2A bromodomain in complex with acetylindole compound UZH47
分子名称: Bromodomain adjacent to zinc finger domain protein 2A, MAGNESIUM ION, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide
著者Dalle Vedove, A, Unzue, A, Nevado, C, Lolli, G, Caflisch, A.
登録日2018-01-11
公開日2018-05-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains.
ChemMedChem, 13, 2018
6ZOT
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Crystal structure of YTHDF3 YTH domain in complex with m6A RNA
分子名称: RNA, YTH domain-containing family protein 3
著者Bedi, R.K, Caflisch, A.
登録日2020-07-07
公開日2020-10-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and Dynamic Insights into Redundant Function of YTHDF Proteins.
J.Chem.Inf.Model., 60, 2020
8Q2Q
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Crystal structure of YTHDC1 in complex with Compound 2b (YL_32)
分子名称: 2-chloranyl-~{N},9-dimethyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Li, Y, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 2b (YL_32)
To Be Published
8Q4W
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Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a)
分子名称: 5-chloranyl-3-[(3-chlorophenyl)methyl]-~{N}-methyl-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-07
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 40 (CS_3a)
To Be Published
8Q2X
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Crystal structure of YTHDC1 in complex with Compound 10 (ZA_294)
分子名称: 3-[2-chloranyl-6-(methylamino)purin-9-yl]benzoic acid, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 10 (ZA_294)
To Be Published
8Q4U
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Crystal structure of YTHDC1 in complex with Compound 36 (ZA_540b)
分子名称: 9-[(3-chlorophenyl)methyl]-2-fluoranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-07
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.37 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 36 (ZA_540b)
To Be Published
8Q31
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Crystal structure of YTHDC1 in complex with Compound 12 (ZA_341)
分子名称: 9-[(2-aminophenyl)methyl]-2-chloranyl-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 12 (ZA_341)
To Be Published
8Q4V
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Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356)
分子名称: 2-chloranyl-9-[(3-chlorophenyl)methyl]-~{N}-cyclopropyl-7,8-dihydropurin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-07
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 37 (ZA_356)
To Be Published
8Q32
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Crystal structure of YTHDC1 in complex with Compound 13 (ZA_364)
分子名称: SULFATE ION, YTH domain-containing protein 1, ~{N}-[2-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]phenyl]methanesulfonamide
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 13 (ZA_364)
To Be Published
8Q2S
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Crystal structure of YTHDC1 in complex with Compound 4 (ZA_232)
分子名称: 2-chloranyl-~{N}-methyl-9-phenyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 4 (ZA_232)
To Be Published
8Q2T
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Crystal structure of YTHDC1 in complex with Compound 5 (ZA_236)
分子名称: 2-chloranyl-~{N}-methyl-9-(phenylmethyl)purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 5 (ZA_236)
To Be Published
8Q2W
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Crystal structure of YTHDC1 in complex with Compound 8 (CS_01)
分子名称: 2-chloranyl-9-(cyclohexylmethyl)-~{N}-methyl-purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 8 (CS_01)
To Be Published
8Q38
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Crystal structure of YTHDC1 in complex with Compound 19 (ZA_347)
分子名称: SULFATE ION, YTH domain-containing protein 1, methyl 3-[[2-chloranyl-6-(methylamino)purin-9-yl]methyl]benzoate
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 19 (ZA_347)
To Be Published
8Q2U
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Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
分子名称: 2-chloranyl-~{N}-methyl-9-(pyridin-4-ylmethyl)purin-6-amine, SULFATE ION, YTH domain-containing protein 1
著者Bedi, R.K, Zalesak, F, Caflisch, A.
登録日2023-08-03
公開日2023-12-06
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Crystal structure of YTHDC1 in complex with Compound 6 (ZA_308)
To Be Published

219869

件を2024-05-15に公開中

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