5E74

Crystal Structure of BAZ2B bromodomain in complex with acetylindole compound UZH50

Summary for 5E74

• Entry DOI: 10.2210/pdb5e74/pdb
• Related: 5E73
• Descriptor: Bromodomain adjacent to zinc finger domain protein 2B, N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)-3-(trifluoromethyl)benzamide (3 entities in total)
• Functional Keywords: four helical bundle, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q9UIF8
• Total number of polymer chains: 1
• Total formula weight: 13984.00

Authors

Lolli, G.,Spiliotopoulos, D.,Dolbois, A.,Nevado, C.,Caflisch, A. (deposition date: 2015-10-11, release date: 2015-10-21, Last modification date: 2024-01-10)

• Primary citation: Unzue, A.,Zhao, H.,Lolli, G.,Dong, J.,Zhu, J.,Zechner, M.,Dolbois, A.,Caflisch, A.,Nevado, C.; The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains.; J. Med. Chem., 59:3087-3097, 2016; PubMed: 26982797; DOI: 10.1021/acs.jmedchem.5b01757

Experimental method

X-RAY DIFFRACTION (1.783 Å)