5D7X

Crystal structure of the human BRPF1 bromodomain in complex with XZ08

Summary for 5D7X

Entry DOI	10.2210/pdb5d7x/pdb
Descriptor	Peregrin, NITRATE ION, 4-(1-acetyl-1H-indol-3-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one, ... (4 entities in total)
Functional Keywords	bromodomain and phd finger-containing protein 1(brpf1), monocytic leukemia zinc-finger (moz), inhibitor, dna binding protein
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P55201
Total number of polymer chains	1
Total formula weight	14020.98
Authors	Zhu, J.,Caflisch, A. (deposition date: 2015-08-14, release date: 2016-05-25, Last modification date: 2024-01-10)
Primary citation	Unzue, A.,Zhao, H.,Lolli, G.,Dong, J.,Zhu, J.,Zechner, M.,Dolbois, A.,Caflisch, A.,Nevado, C. The "Gatekeeper" Residue Influences the Mode of Binding of Acetyl Indoles to Bromodomains. J.Med.Chem., 59:3087-3097, 2016 Cited by PubMed: 26982797 DOI: 10.1021/acs.jmedchem.5b01757 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation