5AJ0
 
 | | Cryo electron microscopy of actively translating human polysomes (POST state). | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ... | | Authors: | Behrmann, E, Loerke, J, Budkevich, T.V, Yamamoto, K, Schmidt, A, Penczek, P.A, Vos, M.R, Burger, J, Mielke, T, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-02-19 | | Release date: | 2015-05-20 | | Last modified: | 2025-10-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural Snapshots of Actively Translating Human Ribosomes
Cell(Cambridge,Mass.), 161, 2015
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5FLX
 | | Mammalian 40S HCV-IRES complex | | Descriptor: | 18S RRNA, 40S RIBOSOMAL PROTEIN S10, 40S RIBOSOMAL PROTEIN S11, ... | | Authors: | Yamamoto, H, Collier, M, Loerke, J, Ismer, J, Schmidt, A, Hilal, T, Sprink, T, Yamamoto, K, Mielke, T, Burger, J, Shaikh, T.R, Dabrowski, M, Hildebrand, P.W, Scheerer, P, Spahn, C.M.T. | | Deposit date: | 2015-10-28 | | Release date: | 2015-12-23 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Molecular Architecture of the Ribosome-Bound Hepatitis C Virus Internal Ribosomal Entry Site RNA.
Embo J., 34, 2015
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4UJD
 | | mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state | | Descriptor: | 18S Ribosomal RNA, 28S Ribosomal RNA, 40S RIBOSOMAL PROTEIN ES1, ... | | Authors: | Yamamoto, H, Unbehaun, A, Loerke, J, Behrmann, E, Marianne, C, Burger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2014-06-18 | | Release date: | 2014-07-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Structure of the Mammalian 80S Initiation Complex with Eif5B on Hcv Ires
Nat.Struct.Mol.Biol., 21, 2014
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4UJC
 | | mammalian 80S HCV-IRES initiation complex with eIF5B POST-like state | | Descriptor: | 18S RIBOSOMAL RNA, 28S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN ES1, ... | | Authors: | Yamamoto, H, Unbehaun, A, Loerke, J, Behrmann, E, Marianne, C, Burger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2014-06-18 | | Release date: | 2014-07-30 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Structure of the Mammalian 80S Initiation Complex with Initiation Factor 5B on Hcv-Ires RNA.
Nat.Struct.Mol.Biol., 21, 2014
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6HHC
 | | Allosteric Inhibition as a new mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated form of Coagulation Factor XI | | Descriptor: | Coagulation factor XI, DIMETHYL SULFOXIDE, FXIA ANTIBODY FAB HEAVY CHAIN, ... | | Authors: | Schaefer, M, Buchmueller, A, Dittmer, F, Strassburger, J, Wilmen, A. | | Deposit date: | 2018-08-27 | | Release date: | 2019-09-11 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI.
J.Mol.Biol., 431, 2019
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3JCJ
 | | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Sprink, T, Ramrath, D.J.F, Yamamoto, H, Yamamoto, K, Loerke, J, Ismer, J, Hildebrand, P.W, Scheerer, P, Buerger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2015-12-18 | | Release date: | 2016-03-09 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association.
Sci Adv, 2, 2016
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7PIU
 | | Cryo-EM structure of the agonist setmelanotide bound to the active melanocortin-4 receptor (MC4R) in complex with the heterotrimeric Gs protein at 2.6 A resolution. | | Descriptor: | CALCIUM ION, Camelid antibody fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | | Deposit date: | 2021-08-23 | | Release date: | 2021-11-17 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.58 Å) | | Cite: | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
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7PIV
 | | Active Melanocortin-4 receptor (MC4R)- Gs protein complex bound to agonist NDP-alpha-MSH at 2.86 A resolution. | | Descriptor: | CALCIUM ION, Camelid antibody VHH fragment - nanobody 35, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Heyder, N.A, Schmidt, A, Kleinau, G, Hilal, T, Scheerer, P. | | Deposit date: | 2021-08-23 | | Release date: | 2021-11-17 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-alpha-MSH and setmelanotide.
Cell Res., 31, 2021
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8PEG
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8PKL
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5T4X
 | | CRYSTAL STRUCTURE OF PDE6D IN APO-STATE | | Descriptor: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | Authors: | Qureshi, B.M, Schmidt, A, Scheerer, P. | | Deposit date: | 2016-08-30 | | Release date: | 2018-01-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Mechanistic insights into the role of prenyl-binding protein PrBP/ delta in membrane dissociation of phosphodiesterase 6.
Nat Commun, 9, 2018
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6R3B
 | | BACTERIOPHAGE SPP1 PROCAPSID-I PROTEIN | | Descriptor: | Major capsid protein | | Authors: | Ignatiou, A, Brasiles, S, El Sadek-Fadel, M, Buerger, J, Mielke, T, Topf, M, Tavares, P. | | Deposit date: | 2019-03-19 | | Release date: | 2019-10-23 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural transitions during the scaffolding-driven assembly of a viral capsid.
Nat Commun, 10, 2019
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6R3A
 | | BACTERIOPHAGE SPP1 MATURE CAPSID PROTEIN | | Descriptor: | Major capsid protein | | Authors: | Ignatiou, A, El Sadek Fadel, M, Buerger, J, Mielke, T, Topf, M, Tavares, P. | | Deposit date: | 2019-03-19 | | Release date: | 2019-10-23 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural transitions during the scaffolding-driven assembly of a viral capsid.
Nat Commun, 10, 2019
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3JCN
 | | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association: Initiation Complex I | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Sprink, T, Ramrath, D.J.F, Yamamoto, H, Yamamoto, K, Loerke, J, Ismer, J, Hildebrand, P.W, Scheerer, P, Buerger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2016-01-04 | | Release date: | 2016-03-09 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association.
Sci Adv, 2, 2016
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5M1J
 | | Nonstop ribosomal complex bound with Dom34 and Hbs1 | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Hilal, T, Yamamoto, H, Loerke, J, Buerger, J, Mielke, T, Spahn, C.M.T. | | Deposit date: | 2016-10-07 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution.
Nat Commun, 7, 2016
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5LM7
 | | Crystal structure of the lambda N-Nus factor complex | | Descriptor: | 30S ribosomal protein S10, Antitermination protein N, N utilization substance protein B homolog, ... | | Authors: | Said, N, Santos, K, Weber, G, Wahl, M.C. | | Deposit date: | 2016-07-29 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Structural basis for lambda N-dependent processive transcription antitermination.
Nat Microbiol, 2, 2017
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5LM9
 | | Structure of E. coli NusA | | Descriptor: | MAGNESIUM ION, SULFATE ION, Transcription termination/antitermination protein NusA | | Authors: | Said, N, Weber, G, Santos, K, Wahl, M.C. | | Deposit date: | 2016-07-29 | | Release date: | 2017-04-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.143 Å) | | Cite: | Structural basis for lambda N-dependent processive transcription antitermination.
Nat Microbiol, 2, 2017
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5MS0
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8QYX
 | | Human 60S ribosomal subunit | | Descriptor: | 1,4-DIAMINOBUTANE, 28S rRNA, 5.8S rRNA, ... | | Authors: | Wiechert, F, Schacherl, M, Sprink, T. | | Deposit date: | 2023-10-26 | | Release date: | 2024-12-11 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (1.78 Å) | | Cite: | Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.
Nucleic Acids Res., 53, 2025
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6ZX9
 | | Crystal structure of SIV Vpr,fused to T4 lysozyme, isolated from moustached monkey, bound to human DDB1 and human DCAF1 (amino acid residues 1046-1396) | | Descriptor: | DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, GLYCEROL, ... | | Authors: | Schwefel, D, Banchenko, S. | | Deposit date: | 2020-07-29 | | Release date: | 2021-07-21 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.519729 Å) | | Cite: | Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses.
Plos Pathog., 17, 2021
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6ZUE
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8R3V
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8RCL
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6GZ4
 | | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-2 (TI-POST-2) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | | Deposit date: | 2018-07-03 | | Release date: | 2018-12-05 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
Cell Rep, 25, 2018
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6GZ5
 | | tRNA translocation by the eukaryotic 80S ribosome and the impact of GTP hydrolysis, Translocation-intermediate-POST-3 (TI-POST-3) | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Flis, J, Holm, M, Rundlet, E.J, Loerke, J, Hilal, T, Dabrowski, M, Buerger, J, Mielke, T, Blanchard, S.C, Spahn, C.M.T, Budkevich, T.V. | | Deposit date: | 2018-07-03 | | Release date: | 2018-12-05 | | Last modified: | 2022-03-30 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.
Cell Rep, 25, 2018
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