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Human two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称:	ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Brohawn, S.G, Mackinnon, R.
登録日	2012-12-05
公開日	2013-01-23
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. Proc.Natl.Acad.Sci.USA, 110, 2013

3UM7

Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1)
分子名称:	POTASSIUM ION, Potassium channel subfamily K member 4
著者	Brohawn, S.G, MacKinnon, R.
登録日	2011-11-12
公開日	2012-02-08
実験手法	X-RAY DIFFRACTION (3.31 Å)
主引用文献	Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science, 335, 2012

3EWE

Crystal Structure of the Nup85/Seh1 Complex
分子名称:	Nucleoporin NUP85, Nucleoporin SEH1
著者	Brohawn, S.G, Leksa, N.C, Rajashankar, K.R, Schwartz, T.U.
登録日	2008-10-14
公開日	2008-11-11
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	Structural evidence for common ancestry of the nuclear pore complex and vesicle coats. Science, 322, 2008

3JRP

SEC13 with NUP145C (AA109-179) insertion blade
分子名称:	FUSION PROTEIN OF PROTEIN TRANSPORT PROTEIN SEC13 AND NUCLEOPORIN NUP145
著者	Brohawn, S.G, Gogola, M, Schwartz, T.U.
登録日	2009-09-08
公開日	2009-10-27
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009

3JRO

NUP84-NUP145C-SEC13 edge element of the NPC lattice
分子名称:	Fusion Protein of Protein Transport Protein SEC13 and Nucleoporin NUP145, Nucleoporin NUP84
著者	Brohawn, S.G, Schwartz, T.U.
登録日	2009-09-08
公開日	2009-10-27
最終更新日	2017-08-02
実験手法	X-RAY DIFFRACTION (4.004 Å)
主引用文献	Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice. Nat.Struct.Mol.Biol., 16, 2009

4WFH

Human TRAAK K+ channel in a Tl+ bound nonconductive conformation
分子名称:	ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Brohawn, S.G, MacKinnon, R.
登録日	2014-09-15
公開日	2014-12-03
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (3.01 Å)
主引用文献	Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014

4WFE

Human TRAAK K+ channel in a K+ bound conductive conformation
分子名称:	ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Brohawn, S.G, MacKinnon, R.
登録日	2014-09-15
公開日	2014-12-03
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014

4WFG

Human TRAAK K+ channel in a Tl+ bound conductive conformation
分子名称:	ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Brohawn, S.G, MacKinnon, R.
登録日	2014-09-15
公開日	2014-12-03
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014

4WFF

Human TRAAK K+ channel in a K+ bound nonconductive conformation
分子名称:	ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Brohawn, S.G, MacKinnon, R.
登録日	2014-09-15
公開日	2014-12-03
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature, 516, 2014

6PIS

Mouse two pore domain K+ channel TRAAK (K2P4.1) - Fab complex structure
分子名称:	ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, POTASSIUM ION, ...
著者	Brohawn, S.G.
登録日	2019-06-27
公開日	2019-12-25
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.77 Å)
主引用文献	The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife, 8, 2019

6XDC

Cryo-EM structure of SARS-CoV-2 ORF3a
分子名称:	ORF3a protein
著者	Kern, D.M, Hoel, C.M, Brohawn, S.G.
登録日	2020-06-10
公開日	2020-06-17
最終更新日	2022-08-31
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021

6WLV

TASK2 in MSP1D1 lipid nanodisc at pH 6.5
分子名称:	POTASSIUM ION, Potassium channel TASK2
著者	Li, B, Brohawn, S.G.
登録日	2020-04-20
公開日	2020-07-15
最終更新日	2020-10-28
実験手法	ELECTRON MICROSCOPY (3.45 Å)
主引用文献	Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020

6WM0

TASK2 in MSP1D1 lipid nanodisc at pH 8.5
分子名称:	POTASSIUM ION, Potassium channel TASK2
著者	Li, B, Brohawn, S.G.
登録日	2020-04-20
公開日	2020-07-15
最終更新日	2020-10-28
実験手法	ELECTRON MICROSCOPY (3.52 Å)
主引用文献	Structural basis for pH gating of the two-pore domain K + channel TASK2. Nature, 586, 2020

7SK0

TWIK1 in MSP1D1 lipid nanodisc at pH 7.4
分子名称:	N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1
著者	Turney, T.S, Brohawn, S.G.
登録日	2021-10-19
公開日	2021-11-24
最終更新日	2022-06-22
実験手法	ELECTRON MICROSCOPY (3.33 Å)
主引用文献	Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022

7SK1

TWIK1 in MSP1E3D1 Lipid Nanodisc at pH 5.5
分子名称:	N-OCTANE, POTASSIUM ION, Potassium channel subfamily K member 1, ...
著者	Turney, T.S, Brohawn, S.G.
登録日	2021-10-19
公開日	2021-11-24
最終更新日	2022-06-22
実験手法	ELECTRON MICROSCOPY (3.43 Å)
主引用文献	Structural Basis for pH-gating of the K + channel TWIK1 at the selectivity filter. Nat Commun, 13, 2022

7RTU

Cryo-EM structure of a TTYH2 trans-dimer
分子名称:	Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Li, B, Brohawn, S.G, Hoel, C.M.
登録日	2021-08-15
公開日	2021-08-25
最終更新日	2022-03-09
実験手法	ELECTRON MICROSCOPY (3.89 Å)
主引用文献	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021

7RTT

Cryo-EM structure of a TTYH2 cis-dimer
分子名称:	CALCIUM ION, Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Li, B, Brohawn, S.G, Hoel, C.M.
登録日	2021-08-15
公開日	2021-08-25
最終更新日	2022-03-09
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021

7RTW

Cryo-EM structure of a TTYH3 cis-dimer
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者	Li, B, Brohawn, S.G, Hoel, C.M.
登録日	2021-08-15
公開日	2021-08-25
最終更新日	2022-03-09
実験手法	ELECTRON MICROSCOPY (3.23 Å)
主引用文献	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021

7RTV

Cryo-EM structure of monomeric TTYH2
分子名称:	Protein tweety homolog 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者	Li, B, Brohawn, S.G, Hoel, C.M.
登録日	2021-08-15
公開日	2021-09-22
最終更新日	2022-04-06
実験手法	ELECTRON MICROSCOPY (3.96 Å)
主引用文献	Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca 2+ -dependent switch from intra- to intermembrane dimerization. Nat Commun, 12, 2021

6UKN

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
分子名称:	CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ...
著者	Reid, M.S, Kern, D.M, Brohawn, S.G.
登録日	2019-10-05
公開日	2020-06-10
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.65 Å)
主引用文献	Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs. Elife, 9, 2020

7M17

SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
分子名称:	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
著者	Kern, D.M, Gerber, E.E, Brohawn, S.G.
登録日	2021-03-12
公開日	2021-03-24
最終更新日	2022-02-23
実験手法	ELECTRON MICROSCOPY (3.65 Å)
主引用文献	Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022

7M19

SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
分子名称:	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
著者	Kern, D.M, Gerber, E.E, Brohawn, S.G.
登録日	2021-03-12
公開日	2021-03-24
最終更新日	2022-02-23
実験手法	ELECTRON MICROSCOPY (3.69 Å)
主引用文献	Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes. Nat Commun, 13, 2022

3HXR

Nucleoporin Nup120 from S.cerevisiae (aa 1-757)
分子名称:	Nucleoporin NUP120
著者	Leksa, N.C, Brohawn, S.G, Schwartz, T.U.
登録日	2009-06-21
公開日	2009-07-28
最終更新日	2017-11-01
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	The structure of the scaffold nucleoporin Nup120 reveals a new and unexpected domain architecture. Structure, 17, 2009

7KJR

Cryo-EM structure of SARS-CoV-2 ORF3a
分子名称:	1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein
著者	Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G.
登録日	2020-10-26
公開日	2020-11-18
最終更新日	2022-08-31
実験手法	ELECTRON MICROSCOPY (2.08 Å)
主引用文献	Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Nat.Struct.Mol.Biol., 28, 2021

7LJB

Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation
分子名称:	ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ...
著者	Rietmeijer, R.A, Brohawn, S.G.
登録日	2021-01-28
公開日	2021-06-30
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.97 Å)
主引用文献	Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK. Neuron, 109, 2021

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