6ONY
 
 | | BRD2_Bromodomain1 complex with inhibitor 744 | | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 2, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide | | 著者 | Longenecker, K.L, Bigelow, L. | | 登録日 | 2019-04-22 | | 公開日 | 2020-01-29 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature, 578, 2020
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6E6J
 | | BRD2_Bromodomain2 complex with inhibitor 744 | | 分子名称: | Bromodomain-containing protein 2, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide | | 著者 | Longenecker, K.L, Park, C.H, Bigelow, L. | | 登録日 | 2018-07-25 | | 公開日 | 2019-07-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature, 578, 2020
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5I2H
 | | Crystal structure of O-methyltransferase family 2 protein Plim_1147 from Planctomyces limnophilus DSM 3776 complex with Apigenin | | 分子名称: | 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, FORMIC ACID, ... | | 著者 | Chang, C, Duke, N, Bigelow, L, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2016-02-08 | | 公開日 | 2016-03-02 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (1.551 Å) | | 主引用文献 | Crystal structure of O-methyltransferase family 2 protein Plim_1147 from Planctomyces limnophilus DSM 3776 complex with Apigenin.
To Be Published
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7LAW
 | | crystal structure of GITR complex with GITR-L | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | | 著者 | Longenecker, K.L, Rogers, B, Bigelow, L, Judge, R.A, Alvarez, H. | | 登録日 | 2021-01-07 | | 公開日 | 2022-03-09 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.752 Å) | | 主引用文献 | An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.
Nat Cancer, 3, 2022
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6QKY
 | | Tryptophan synthase subunit alpha from Streptococcus pneumoniae with 3D domain swap in the core of TIM barrel | | 分子名称: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Michalska, K, Kowiel, M, Bigelow, L, Endres, M, Gilski, M, Jaskolski, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2019-01-30 | | 公開日 | 2019-03-27 | | 最終更新日 | 2022-03-30 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | 3D domain swapping in the TIM barrel of the alpha subunit of Streptococcus pneumoniae tryptophan synthase.
Acta Crystallogr D Struct Biol, 76, 2020
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6NTR
 | | Crystal Structure of Beta-barrel-like Protein of Domain of Unknown Function DUF1849 from Brucella abortus | | 分子名称: | 1,2-ETHANEDIOL, ATP/GTP-binding site-containing protein A, GLYCEROL | | 著者 | Kim, Y, Bigelow, L, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2019-01-30 | | 公開日 | 2019-02-13 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | | 主引用文献 | BrucellaPeriplasmic Protein EipB Is a Molecular Determinant of Cell Envelope Integrity and Virulence.
J.Bacteriol., 201, 2019
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2A5Z
 | | Crystal Structure of Protein of Unknown Function SO2946 from Shewanella oneidensis MR-1 | | 分子名称: | MAGNESIUM ION, hypothetical protein SO2946 | | 著者 | Nocek, B, Bigelow, L, Abdullah, J, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2005-07-01 | | 公開日 | 2005-08-16 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.015 Å) | | 主引用文献 | Structure of SO2946 orphan from Shewanella oneidensis shows "jelly-roll" fold with carbohydrate-binding module.
J.STRUCT.FUNCT.GENOM., 9, 2008
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2BBE
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6AZY
 | | Crystal structure of Hsp104 R328M/R757M mutant from Calcarisporiella thermophila | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Heat shock protein Hsp104 | | 著者 | Michalska, K, Bigelow, L, Hatzos-Skintges, C, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2017-09-13 | | 公開日 | 2018-10-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.
Structure, 27, 2019
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5KCK
 | | Crystal structure of anthranilate synthase component I from Streptococcus pneumoniae TIGR4 | | 分子名称: | Anthranilate synthase component I, GLYCEROL | | 著者 | Chang, C, Michalska, K, Bigelow, L, Jedrzejczak, R, ANDERSON, W.F, JOACHIMIAK, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-06-06 | | 公開日 | 2016-06-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of anthranilate synthase component I from Streptococcus pneumoniae TIGR4
To Be Published
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5KIN
 | | Crystal structure of tryptophan synthase alpha beta complex from Streptococcus pneumoniae | | 分子名称: | GLYCEROL, Tryptophan synthase alpha chain, Tryptophan synthase beta chain | | 著者 | Chang, C, Michalska, K, Bigelow, L, Jedrzejczak, R, ANDERSON, W.F, JOACHIMIAK, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2016-06-16 | | 公開日 | 2016-07-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Conservation of the structure and function of bacterial tryptophan synthases.
Iucrj, 6, 2019
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5BMQ
 | | Crystal structure of L,D-transpeptidase (Yku) from Stackebrandtia nassauensis | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ErfK/YbiS/YcfS/YnhG family protein, GLYCEROL, ... | | 著者 | Chang, C, Bigelow, L, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2015-05-22 | | 公開日 | 2015-06-03 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Crystal structures of L,D-transpeptidases (Yku)
To be Published
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5CJ3
 | | Crystal structure of the zorbamycin binding protein (ZbmA) from Streptomyces flavoviridis with zorbamycin | | 分子名称: | CHLORIDE ION, COPPER (II) ION, Zbm binding protein, ... | | 著者 | Chang, C, Bigelow, L, Clancy, S, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Rudolf, J.D, Ma, M, Chang, C.-Y, Lohman, J.R, Yang, D, Shen, B, Enzyme Discovery for Natural Product Biosynthesis, Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-07-13 | | 公開日 | 2015-07-22 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6499 Å) | | 主引用文献 | Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.
Biochemistry, 54, 2015
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5CQF
 | | Crystal structure of L-lysine 6-monooxygenase from Pseudomonas syringae | | 分子名称: | IODIDE ION, L-lysine 6-monooxygenase | | 著者 | Michalska, K, Bigelow, L, Jedrzejczak, R, Weerth, R.S, Cao, H, Yennamalli, R, Phillips Jr, G.N, Thomas, M.G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-07-21 | | 公開日 | 2015-09-30 | | 最終更新日 | 2019-12-25 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Crystal structure of L-lysine 6-monooxygenase from Pseudomonas syringae
To Be Published
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5DU2
 | | Structural analysis of EspG2 glycosyltransferase | | 分子名称: | EspG2 glycosyltransferase | | 著者 | Michalska, K, Elshahawi, S.I, Bigelow, L, Babnigg, G, Thorson, J.S, Phillips Jr, G.N, Joachimiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2015-09-18 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural analysis of EspG2 glycosyltransferase
To Be Published
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5UC0
 | | Crystal Structure of Beta-barrel-like, Uncharacterized Protein of COG5400 from Brucella abortus | | 分子名称: | CHLORIDE ION, PENTAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Kim, Y, Bigelow, L, Endres, M, Babnigg, G, Crosson, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2016-12-21 | | 公開日 | 2017-02-08 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.
Mol. Microbiol., 2018
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5UID
 | | The crystal structure of an aminotransferase TlmJ from Streptoalloteichus hindustanus | | 分子名称: | Aminotransferase TlmJ, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION | | 著者 | Tan, K, Bigelow, L, Bearden, J, Phillips Jr, G.N, Joachmiak, A, Midwest Center for Structural Genomics (MCSG), Enzyme Discovery for Natural Product Biosynthesis (NatPro) | | 登録日 | 2017-01-13 | | 公開日 | 2017-02-01 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | The crystal structure of an aminotransferase TlmJ from Streptoalloteichus hindustanus.
To Be Published
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5ULB
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2FG1
 | | Structure of a Protein of Unknown Function from Bacteroides thetaiotaomicron. | | 分子名称: | conserved hypothetical protein BT1257 | | 著者 | Cuff, M.E, Bigelow, L, Abdullah, J, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2005-12-20 | | 公開日 | 2006-03-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structure of a hypothetical protein from Bacteroides thetaiotaomicron.
To be Published
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2G03
 | | Structure of a putative cell filamentation protein from Neisseria meningitidis. | | 分子名称: | ACETIC ACID, ISOPROPYL ALCOHOL, hypothetical protein NMA0004 | | 著者 | Cuff, M.E, Bigelow, L, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2006-02-10 | | 公開日 | 2006-03-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of a putative cell filamentation protein from Neisseria meningitidis.
To be Published
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2H5N
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2IAZ
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2R5R
 | | The crystal structure of DUF198 from Nitrosomonas europaea ATCC 19718 | | 分子名称: | IMIDAZOLE, PHOSPHATE ION, UPF0343 protein NE1163 | | 著者 | Tan, K, Wu, R, Nocek, B, Bigelow, L, Patterson, S, Freeman, L, Bargassa, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2007-09-04 | | 公開日 | 2007-09-18 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | The crystal structure of DUF198 from Nitrosomonas europaea ATCC 19718.
To be Published
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3TEB
 | | endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b | | 分子名称: | Endonuclease/exonuclease/phosphatase, MAGNESIUM ION | | 著者 | Chang, C, Bigelow, L, Muniez, I, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2011-08-12 | | 公開日 | 2011-08-31 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Crystal structure of endonuclease/exonuclease/phosphatase family protein from Leptotrichia buccalis C-1013-b
To be Published
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3T8K
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