6E6J
BRD2_Bromodomain2 complex with inhibitor 744
Summary for 6E6J
Entry DOI | 10.2210/pdb6e6j/pdb |
Descriptor | Bromodomain-containing protein 2, N-ethyl-4-[2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl]-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (3 entities in total) |
Functional Keywords | bet, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 6 |
Total formula weight | 82054.17 |
Authors | Longenecker, K.L.,Park, C.H.,Bigelow, L. (deposition date: 2018-07-25, release date: 2019-07-31, Last modification date: 2024-03-13) |
Primary citation | Faivre, E.J.,McDaniel, K.F.,Albert, D.H.,Mantena, S.R.,Plotnik, J.P.,Wilcox, D.,Zhang, L.,Bui, M.H.,Sheppard, G.S.,Wang, L.,Sehgal, V.,Lin, X.,Huang, X.,Lu, X.,Uziel, T.,Hessler, P.,Lam, L.T.,Bellin, R.J.,Mehta, G.,Fidanze, S.,Pratt, J.K.,Liu, D.,Hasvold, L.A.,Sun, C.,Panchal, S.C.,Nicolette, J.J.,Fossey, S.L.,Park, C.H.,Longenecker, K.,Bigelow, L.,Torrent, M.,Rosenberg, S.H.,Kati, W.M.,Shen, Y. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature, 578:306-310, 2020 Cited by PubMed: 31969702DOI: 10.1038/s41586-020-1930-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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