7XUQ
 
 | | Crystal structure of Tpe3.0 complexed with N-Boc-3-alkenylindole | | 分子名称: | Transcriptional regulator, PadR-like family, dimethyl 2-[[2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]methyl]-2-prop-2-enyl-propanedioate | | 著者 | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | | 登録日 | 2022-05-19 | | 公開日 | 2022-09-28 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Enantioselective [2+2]-cycloadditions with triplet photoenzymes.
Nature, 611, 2022
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7CCD
 | | Sulfur binding domain of SprMcrA complexed with phosphorothioated DNA | | 分子名称: | DNA (5'-D(*CP*AP*CP*GP*TP*TP*CP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*GP*AS*AP*CP*GP*TP*G)-3'), HNHc domain-containing protein | | 著者 | Yu, H, Li, J, Liu, G, Zhao, G, Wang, Y, Hu, W, Deng, Z, Gan, J, Zhao, Y, He, X. | | 登録日 | 2020-06-16 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses.
Nucleic Acids Res., 48, 2020
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3P9U
 | | Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TetX2 protein | | 著者 | Walkiewicz, K, Davlieva, M, Sun, C, Lau, K, Shamoo, Y. | | 登録日 | 2010-10-18 | | 公開日 | 2011-04-27 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution.
Proteins, 79, 2011
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7ES4
 | | the crystral structure of DndH-C-domain | | 分子名称: | DNA phosphorothioation-dependent restriction protein DptH | | 著者 | Wu, D. | | 登録日 | 2021-05-08 | | 公開日 | 2022-05-11 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
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7EXX
 | | The structure of DndG | | 分子名称: | DNA phosphorothioation-dependent restriction protein DptG, SODIUM ION | | 著者 | Wu, D, Wang, L. | | 登録日 | 2021-05-28 | | 公開日 | 2022-06-01 | | 最終更新日 | 2022-12-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex
Nat Catal, 2022
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6LB9
 | | Magnesium ion-bound SspB crystal structure | | 分子名称: | DUF4007 domain-containing protein, MAGNESIUM ION | | 著者 | Liqiong, L, Yubing, Z. | | 登録日 | 2019-11-13 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.227 Å) | | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
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6ICT
 | | Structure of SETD3 bound to SAH and methylated actin | | 分子名称: | Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... | | 著者 | Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) | | 登録日 | 2018-09-07 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | | 主引用文献 | Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
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6ICV
 | | Structure of SETD3 bound to SAH and unmodified actin | | 分子名称: | Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ... | | 著者 | Guo, Q, Liao, S, Xu, C, Structural Genomics Consortium (SGC) | | 登録日 | 2018-09-07 | | 公開日 | 2019-02-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural insights into SETD3-mediated histidine methylation on beta-actin.
Elife, 8, 2019
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6JIV
 | | SspE crystal structure | | 分子名称: | SspE protein | | 著者 | Bing, Y.Z, Yang, H.G. | | 登録日 | 2019-02-23 | | 公開日 | 2020-03-25 | | 最終更新日 | 2020-07-08 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
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6JJ0
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6O2L
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6JUF
 | | SspB crystal structure | | 分子名称: | SspB protein | | 著者 | Liqiong, L, Yubing, Z. | | 登録日 | 2019-04-13 | | 公開日 | 2020-03-25 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.587 Å) | | 主引用文献 | SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities.
Nat Microbiol, 5, 2020
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7JM5
 | | Crystal structure of KDM4B in complex with QC6352 | | 分子名称: | 3-[({(1R)-6-[methyl(phenyl)amino]-1,2,3,4-tetrahydronaphthalen-1-yl}methyl)amino]pyridine-4-carboxylic acid, Lysine-specific demethylase 4B, NICKEL (II) ION, ... | | 著者 | White, S.W, Yun, M. | | 登録日 | 2020-07-31 | | 公開日 | 2022-02-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.
Sci Transl Med, 14, 2022
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7UAH
 | | Macrocyclic plasmin inhibitor | | 分子名称: | (2~{R})-butane-1,2-diol, (6S,9R,19S,22R)-N-{[4-(aminomethyl)phenyl]methyl}-22-[(3-chlorobenzene-1-sulfonyl)amino]-3,12,21-trioxo-2,6,9,13,20-pentaazatetracyclo[22.2.2.2~6,9~.2~14,17~]dotriaconta-1(26),14,16,24,27,29-hexaene-19-carboxamide, Plasminogen, ... | | 著者 | Guojie, W. | | 登録日 | 2022-03-12 | | 公開日 | 2023-03-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Synthesis and Structural Characterization of Macrocyclic Plasmin Inhibitors.
Chemmedchem, 18, 2023
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7C4A
 | | nicA2 with cofactor FAD | | 分子名称: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Xu, P, Zang, K. | | 登録日 | 2020-05-15 | | 公開日 | 2020-06-03 | | 最終更新日 | 2020-12-16 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
Mbio, 11, 2020
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7C49
 | | nicA2 with cofactor FAD and substrate nicotine | | 分子名称: | 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | | 著者 | Xu, P, Zhang, K. | | 登録日 | 2020-05-15 | | 公開日 | 2020-06-03 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022).
Mbio, 11, 2020
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5V3S
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7F3Q
 | | SARS-CoV-2 RBD in complex with A5-10 Fab and A34-2 Fab | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of A34-2 Fab, ... | | 著者 | Dou, Y, Wang, X, Liu, P, Lu, B, Wang, K. | | 登録日 | 2021-06-16 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-01-24 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Development of neutralizing antibodies against SARS-CoV-2, using a high-throughput single-B-cell cloning method.
Antib Ther, 6, 2023
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6LJH
 | | Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+ | | 分子名称: | Alcohol dehydrogenase 1, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Feng, X, Fan, S, Li, M, Zou, S, Lv, G, Wu, G, Jin, Y, Yang, Z. | | 登録日 | 2019-12-16 | | 公開日 | 2020-12-23 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of Alcohol dehydrogenase 1 from Artemisia annua in complex with NAD+
To Be Published
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5TP9
 | | Structure of the human GluN1/GluN2A LBD in complex with compound 2 (GNE9178) | | 分子名称: | 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, ACETATE ION, CALCIUM ION, ... | | 著者 | Wallweber, H.J.A, Lupardus, P.J. | | 登録日 | 2016-10-20 | | 公開日 | 2016-11-30 | | 最終更新日 | 2017-02-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
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5TPA
 | | Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500) | | 分子名称: | (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile, GLUTAMIC ACID, GLYCINE, ... | | 著者 | Wallweber, H.J.A, Lupardus, P.J. | | 登録日 | 2016-10-20 | | 公開日 | 2016-11-30 | | 最終更新日 | 2017-02-01 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
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4JYA
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-03-29 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.098 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4JV5
 | | Crystal structures of pseudouridinilated stop codons with ASLs | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein 20, 30S ribosomal protein S10, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-03-25 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.162 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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4K0K
 | | Crystal structure of the Thermus thermophilus 30S ribosomal subunit complexed with a serine-ASL and mRNA containing a stop codon | | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | | 著者 | Fernandez, I.S, Ng, C.L, Kelley, A.C, Guowei, W, Yu, Y.T, Ramakrishnan, V. | | 登録日 | 2013-04-04 | | 公開日 | 2013-06-26 | | 最終更新日 | 2013-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Unusual base pairing during the decoding of a stop codon by the ribosome.
Nature, 500, 2013
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5XV7
 | | SRPK1 in complex with Alectinib | | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, serine-arginine (SR) protein kinase 1 | | 著者 | Zeng, C, Ngo, J.C.K. | | 登録日 | 2017-06-26 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | SRPKIN-1: A Covalent SRPK1/2 Inhibitor that Potently Converts VEGF from Pro-angiogenic to Anti-angiogenic Isoform
Cell Chem Biol, 25, 2018
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