4LN0
| Crystal structure of the VGLL4-TEAD4 complex | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Transcription cofactor vestigial-like protein 4, ... | Authors: | Wang, H, Shi, Z, Zhou, Z. | Deposit date: | 2013-07-11 | Release date: | 2014-02-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.896 Å) | Cite: | A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer. Cancer Cell, 25, 2014
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1V3R
| Crystal structure of TT1020 from Thermus thermophilus HB8 | Descriptor: | Nitrogen regulatory protein P-II | Authors: | Wang, H, Sakai, H, Takemoto-Hori, C, Kaminishi, T, Yamaguchi, H, Terada, T, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-11-05 | Release date: | 2004-11-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8. J.Struct.Biol., 149, 2005
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4XCR
| Monomeric Human Cu,Zn Superoxide dismutase, loops IV and VII deleted, apo form, mutant I35A | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Wang, H, Logan, D.T, Danielsson, J, Mu, X, Binolfi, A, Theillet, F, Bekei, B, Lang, L, Wennerstrom, H, Selenko, P, Oliveberg, M. | Deposit date: | 2014-12-18 | Release date: | 2016-01-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.602 Å) | Cite: | Thermodynamics of protein destabilization in live cells. Proc. Natl. Acad. Sci. U.S.A., 112, 2015
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1UFL
| Crystal Structure of TT1020 from Thermus thermophilus HB8 | Descriptor: | Nitrogen regulatory protein P-II | Authors: | Wang, H, Sakai, H, Hori-Takemoto, C, Kaminishi, T, Terada, T, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-31 | Release date: | 2003-11-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8. J.Struct.Biol., 149, 2005
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1V3S
| Crystal structure of TT1020 from Thermus thermophilus HB8 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Nitrogen regulatory protein P-II | Authors: | Wang, H, Sakai, H, Takemoto-Hori, C, Kaminishi, T, Terada, T, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-11-05 | Release date: | 2004-11-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8. J.Struct.Biol., 149, 2005
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1V9O
| Crystal structure of TT1020 from Thermus thermophilus HB8 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NITROGEN REGULATORY PROTEIN PII | Authors: | Wang, H, Sakai, H, Takemoto-Hori, C, Kaminishi, T, Terada, T, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-01-27 | Release date: | 2005-01-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8. J.Struct.Biol., 149, 2005
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1VFJ
| Crystal structure of TT1020 from Thermus thermophilus HB8 | Descriptor: | nitrogen regulatory protein p-II | Authors: | Wang, H, Sakai, H, Takemoto-Hori, C, Kaminishi, T, Terada, T, Kuramitsu, S, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-04-15 | Release date: | 2005-01-11 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8 J.STRUCT.BIOL., 149, 2005
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7F3B
| cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor. | Descriptor: | 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, GLYCEROL | Authors: | Wang, H, You, X.F, Yang, X.Y, Li, Y, Hong, W. | Deposit date: | 2021-06-16 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur.J.Med.Chem., 228, 2022
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6CJ3
| CRYSTAL STRUCTURE OF PROTEIN CITE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM AND PYRUVATE | Descriptor: | ACETATE ION, Citrate lyase subunit beta-like protein, MAGNESIUM ION, ... | Authors: | Fedorov, E.V, Fedorov, A.A, Wang, H, Bonanno, J.B, Carvalho, L, Almo, S.C. | Deposit date: | 2018-02-26 | Release date: | 2018-08-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism. Proc.Natl.Acad.Sci.USA, 116, 2019
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6CHU
| CRYSTAL STRUCTURE OF PROTEIN CITE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM AND ACETATE | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Citrate lyase subunit beta-like protein, ... | Authors: | Fedorov, A.A, Fedorov, E.V, Wang, H, Bonanno, J.B, Carvalho, L, Almo, S.C. | Deposit date: | 2018-02-23 | Release date: | 2018-08-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism. Proc.Natl.Acad.Sci.USA, 116, 2019
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8CEO
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8CEN
| Yeast RNA polymerase II transcription pre-initiation complex with core Mediator | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | Authors: | Wang, H, Schilbach, S, Cramer, P. | Deposit date: | 2023-02-02 | Release date: | 2023-03-22 | Last modified: | 2023-04-19 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain. Proc.Natl.Acad.Sci.USA, 120, 2023
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8H3G
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) E166V Mutant in Complex with Inhibitor Enstrelvir | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, GLYCEROL | Authors: | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3L
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (T21I and E166V) in Complex with Inhibitor Enstrelvir | Descriptor: | 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | Authors: | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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8H3K
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Double Mutant (L50F and E166V) in Complex with Inhibitor Enstrelvir | Descriptor: | 3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM, 3C-like proteinase nsp5, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione, ... | Authors: | Wang, H, Lin, M, Duan, Y, Zhang, X, Zhou, H, Bian, Q, Liu, X, Rao, Z, Yang, H. | Deposit date: | 2022-10-08 | Release date: | 2023-10-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature, 622, 2023
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4Q4C
| Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and synthetic 1,5-(PP)2-IP4 (1,5-IP8) | Descriptor: | (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], ADENOSINE-5'-DIPHOSPHATE, Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, ... | Authors: | Wang, H, Shears, S.B. | Deposit date: | 2014-04-14 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew.Chem.Int.Ed.Engl., 53, 2014
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4Q4D
| Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with AMP-PNP and synthetic 3,5-(PP)2-IP4 (3,5-IP8) | Descriptor: | (1R,3S,4S,5R,6S)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)], Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, MAGNESIUM ION, ... | Authors: | Wang, H, Shears, S.B. | Deposit date: | 2014-04-14 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Synthesis of Densely Phosphorylated Bis-1,5-Diphospho-myo-Inositol Tetrakisphosphate and its Enantiomer by Bidirectional P-Anhydride Formation. Angew.Chem.Int.Ed.Engl., 53, 2014
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7SBF
| PZM21 bound Mu Opioid Receptor-Gi Protein Complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Huang, W, Qu, Q, Wang, H, Skiniotis, G, Kobilka, B. | Deposit date: | 2021-09-24 | Release date: | 2022-04-20 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure-Based Evolution of G Protein-Biased mu-Opioid Receptor Agonists. Angew.Chem.Int.Ed.Engl., 61, 2022
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8JHO
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4I15
| Crystal structure of TbrPDEB1 | Descriptor: | Class 1 phosphodiesterase PDEB1, MAGNESIUM ION, ZINC ION | Authors: | Wang, H, Ke, H. | Deposit date: | 2012-11-20 | Release date: | 2013-03-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure. J.Med.Chem., 56, 2013
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6FLH
| Monomeric Human Cu,Zn Superoxide dismutase, SOD1 7+7, apo form | Descriptor: | GLYCEROL, SULFATE ION, Superoxide dismutase [Cu-Zn] | Authors: | Wang, H, Yang, F, Logan, D, Oliveberg, M. | Deposit date: | 2018-01-25 | Release date: | 2018-11-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | The Cost of Long Catalytic Loops in Folding and Stability of the ALS-Associated Protein SOD1. J.Am.Chem.Soc., 140, 2018
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5DJU
| Crystal structure of LOV2 (C450A) domain in complex with Zdk3 | Descriptor: | CHLORIDE ION, Engineered protein, Zdk3 affibody, ... | Authors: | Tarnawski, M, Wang, H, Yumerefendi, H, Hahn, K.M, Schlichting, I. | Deposit date: | 2015-09-02 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat.Methods, 13, 2016
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5DJT
| Crystal structure of LOV2 (C450A) domain in complex with Zdk2 | Descriptor: | CHLORIDE ION, COPPER (II) ION, Engineered protein, ... | Authors: | Tarnawski, M, Wang, H, Yumerefendi, H, Hahn, K.M, Schlichting, I. | Deposit date: | 2015-09-02 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat.Methods, 13, 2016
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5EFW
| Crystal structure of LOV2-Zdk1 - the complex of oat LOV2 and the affibody protein Zdark1 | Descriptor: | FLAVIN MONONUCLEOTIDE, NPH1-1, SULFATE ION, ... | Authors: | Winkler, A, Wang, H, Hartmann, E, Hahn, K, Schlichting, I. | Deposit date: | 2015-10-26 | Release date: | 2016-07-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nat.Methods, 13, 2016
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4IQ8
| Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase 3 | Authors: | Wang, H, Liu, Q, Niu, L, Teng, M, Li, X. | Deposit date: | 2013-01-11 | Release date: | 2013-02-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Preliminary crystallographic analysis of glyceraldehyde-3-phosphate dehydrogenase 3 from Saccharomyces cerevisiae. Acta Crystallogr.,Sect.F, 68, 2012
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