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Cryo-EM structure of the Sinorhizobium meliloti flagellar filament
Descriptor:	Flagellin A
Authors:	Kreutzberger, M.A.B, Scharf, B.E, Egelman, E.H.
Deposit date:	2021-10-27
Release date:	2022-03-16
Last modified:	2022-03-30
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. Nat Commun, 13, 2022

7SQJ

Cryo-EM structure of the seam subunits of the enteropathogenic E. coli O127:H6 flagellar filament
Descriptor:	Flagellin
Authors:	Kreutzberger, M.A.B, Chatterjee, S, Frankel, G, Egelman, E.H.
Deposit date:	2021-11-05
Release date:	2022-03-16
Last modified:	2022-03-30
Method:	ELECTRON MICROSCOPY (6.3 Å)
Cite:	Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. Nat Commun, 13, 2022

7SN7

Cryo-EM structure of the enteropathogenic E. coli O127:H6 flagellar filament
Descriptor:	Flagellin
Authors:	Kreutzberger, M.A.B, Chatterjee, S, Frankel, G, Egelman, E.H.
Deposit date:	2021-10-27
Release date:	2022-03-16
Last modified:	2022-03-30
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments. Nat Commun, 13, 2022

8EXH

Agrobacterium tumefaciens Tpilus
Descriptor:	(14S,17R)-20-amino-17-hydroxy-11,17-dioxo-12,16,18-trioxa-17lambda~5~-phosphaicosan-14-yl tetradecanoate, Protein virB2
Authors:	Beltran, L.C, Egelman, E.H.
Deposit date:	2022-10-25
Release date:	2023-03-22
Last modified:	2023-04-26
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Archaeal DNA-import apparatus is homologous to bacterial conjugation machinery Nat Commun, 14, 2023

7SZI

Cryo-EM structure of OmpK36-TraN mating pair stabilization proteins from carbapenem-resistant Klebsiella pneumoniae
Descriptor:	OmpK36, TraN
Authors:	Beltran, L.C, Seddon, C, Beis, K, Frankel, G, Egelman, E.H.
Deposit date:	2021-11-27
Release date:	2022-06-08
Last modified:	2022-07-13
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Mating pair stabilization mediates bacterial conjugation species specificity. Nat Microbiol, 7, 2022

7WN8

Crystal structure of antibody (BC31M5) binds to CD47
Descriptor:	BC31M5 Fab Heavy chain, BC31M5 Fab Light chain, Leukocyte surface antigen CD47, ...
Authors:	Li, Y, Wang, W, Sui, J, Zhang, S.
Deposit date:	2022-01-17
Release date:	2023-01-25
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety. J Hematol Oncol, 16, 2023

7TZO

The apo structure of human mTORC2 complex
Descriptor:	Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ...
Authors:	Yu, Z, Chen, J, Pearce, D.
Deposit date:	2022-02-16
Release date:	2023-01-11
Method:	ELECTRON MICROSCOPY (3.28 Å)
Cite:	Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298, 2022

7Y3N

Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, ...
Authors:	Rao, X, Chai, Y, Wu, Y, Gao, F.
Deposit date:	2022-06-11
Release date:	2023-12-27
Method:	X-RAY DIFFRACTION (2.97 Å)
Cite:	Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023

7DQ9

Crystal structure of a type-A feruloyl esterase from gut Alistipes shahii
Descriptor:	Predicted hydrolases or acyltransferases (Alpha/beta hydrolase superfamily)
Authors:	Wei, X, Gu, T.Y, Xin, F.J, Wang, Y.L.
Deposit date:	2020-12-22
Release date:	2021-12-22
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.702 Å)
Cite:	The alpha-Helical Cap Domain of a Novel Esterase from Gut Alistipes shahii Shaping the Substrate-Binding Pocket. J.Agric.Food Chem., 69, 2021

6UIF

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor:	4-{[(5-bromo-3-chloro-2-hydroxyphenyl)sulfonyl]amino}-1-cyclopentyl-N-methyl-1H-imidazole-2-carboxamide, WD repeat domain 5
Authors:	Zhao, B.
Deposit date:	2019-09-30
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.603 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UIK

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor:	5-bromo-3-chloro-N-(1-cyclopentyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domanin 5
Authors:	Zhao, B.
Deposit date:	2019-10-01
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UJH

Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction
Descriptor:	(2R)-2-(4-chlorophenyl)-3-oxobutanenitrile, DIMETHYL SULFOXIDE, SULFATE ION, ...
Authors:	Phan, J, Fesik, S.W.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.493 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UJ4

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor:	5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5
Authors:	Zhao, B.
Deposit date:	2019-10-02
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.53 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UJL

Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction
Descriptor:	6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5
Authors:	Phan, J.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.599 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UJJ

Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction
Descriptor:	5-[4-(trifluoromethyl)phenyl]-1H-tetrazole, WD repeat-containing protein 5
Authors:	Phan, J.
Deposit date:	2019-10-03
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.731 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

7MN6

Structure of the HER2 S310F/HER3/NRG1b Heterodimer Extracellular Domain
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
Authors:	Diwanji, D, Trenker, R, Verba, K.A, Jura, N.
Deposit date:	2021-04-30
Release date:	2021-10-27
Last modified:	2021-12-22
Method:	ELECTRON MICROSCOPY (3.09 Å)
Cite:	Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021

7MN5

Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
Authors:	Diwanji, D, Trenker, R, Verba, K.A, Jura, N.
Deposit date:	2021-04-30
Release date:	2021-10-27
Last modified:	2021-12-22
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021

7MN8

Structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 6 of Pro-neuregulin-1, ...
Authors:	Diwanji, D, Trenker, R, Verba, K.A, Jura, N.
Deposit date:	2021-04-30
Release date:	2021-11-10
Last modified:	2021-12-22
Method:	ELECTRON MICROSCOPY (3.45 Å)
Cite:	Structures of the HER2-HER3-NRG1 beta complex reveal a dynamic dimer interface. Nature, 600, 2021

6VG0

CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN COMPLEX WITH NADPH and AGI-15056
Descriptor:	Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine
Authors:	Padyana, A, Jin, L.
Deposit date:	2020-01-07
Release date:	2020-02-05
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.66 Å)
Cite:	Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. Acs Med.Chem.Lett., 11, 2020

6UTF

Allosteric coupling between alpha-rings of the 20S proteasome, archaea 20S proteasome singly capped with a PAN complex
Descriptor:	Proteasome subunit alpha, Proteasome subunit beta
Authors:	Cheng, Y, Yu, Z.
Deposit date:	2019-10-29
Release date:	2020-09-09
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Allosteric coupling between alpha-rings of the 20S proteasome. Nat Commun, 11, 2020

6UTH

Allosteric coupling between alpha-rings of 20S proteasome, 20S proteasome singly capped with a PA26/E102A_PANc, together with LFP incubation
Descriptor:	Proteasome activator protein PA26, Proteasome subunit alpha, Proteasome subunit beta
Authors:	Cheng, Y, Yu, Z.
Deposit date:	2019-10-29
Release date:	2020-09-09
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Allosteric coupling between alpha-rings of the 20S proteasome. Nat Commun, 11, 2020

6UTJ

Allosteric couple between alpha rings of the 20S proteasome. 20S proteasome singly capped by PA26/E102A, C-terminus replaced by PAN C-terminus
Descriptor:	Proteasome activator protein PA26, Proteasome subunit alpha, Proteasome subunit beta
Authors:	Cheng, Y, Yu, Z.
Deposit date:	2019-10-29
Release date:	2020-09-09
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (2.9 Å)
Cite:	Allosteric coupling between alpha-rings of the 20S proteasome. Nat Commun, 11, 2020

6UTI

Allosteric coupling between alpha-rings of 20S proteasome, 20S proteasome with singly capped PAN complex
Descriptor:	Proteasome subunit alpha, Proteasome subunit beta
Authors:	Cheng, Y, Yu, Z.
Deposit date:	2019-10-29
Release date:	2020-09-09
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Allosteric coupling between alpha-rings of the 20S proteasome. Nat Commun, 11, 2020

6UOZ

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction
Descriptor:	5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5
Authors:	Zhao, B.
Deposit date:	2019-10-16
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.532 Å)
Cite:	Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020

6UTG

Allosteric coupling between alpha-rings of the 20S proteasome, 20S singly capped with a PA26/V230F
Descriptor:	Proteasome activator protein PA26, Proteasome subunit alpha, Proteasome subunit beta
Authors:	Yu, Z, Cheng, Y.
Deposit date:	2019-10-29
Release date:	2020-09-09
Last modified:	2024-03-06
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Allosteric coupling between alpha-rings of the 20S proteasome. Nat Commun, 11, 2020

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