6C0W
 
 | | Cryo-EM structure of human kinetochore protein CENP-N with the centromeric nucleosome containing CENP-A | | Descriptor: | 147 mer DNA, Centromere protein N, Histone H2A, ... | | Authors: | Zhou, K, Pentakota, S, Vetter, I.R, Morgan, G.P, Petrovic, A, Musacchio, A, Luger, K. | | Deposit date: | 2018-01-02 | | Release date: | 2018-01-17 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Decoding the centromeric nucleosome through CENP-N.
Elife, 6, 2017
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1M7B
 | | Crystal structure of Rnd3/RhoE: functional implications | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Rnd3/RhoE small GTP-binding protein | | Authors: | Fiegen, D, Blumenstein, L, Stege, P, Vetter, I.R, Ahmadian, M.R. | | Deposit date: | 2002-07-19 | | Release date: | 2002-08-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of Rnd3/RhoE: functional implications
FEBS LETT., 525, 2002
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1M5I
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1A4R
 | | G12V MUTANT OF HUMAN PLACENTAL CDC42 GTPASE IN THE GDP FORM | | Descriptor: | AMINOPHOSPHONIC ACID-GUANYLATE ESTER, G25K GTP-BINDING PROTEIN, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Rudolph, M.G, Vetter, I.R, Wittinghofer, A. | | Deposit date: | 1998-02-02 | | Release date: | 1999-03-02 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: two different nucleotide states in one crystal.
Protein Sci., 8, 1999
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4O9Y
 | | Crystal Structure of TcdA1 | | Descriptor: | TcdA1 | | Authors: | Meusch, D, Gatsogiannis, C, Efremov, R.G, Lang, A.E, Hofnagel, O, Vetter, I.R, Aktories, K, Raunser, S. | | Deposit date: | 2014-01-03 | | Release date: | 2014-02-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.502 Å) | | Cite: | Mechanism of Tc toxin action revealed in molecular detail.
Nature, 508, 2014
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4O9X
 | | Crystal Structure of TcdB2-TccC3 | | Descriptor: | MERCURY (II) ION, TcdB2, TccC3 | | Authors: | Meusch, D, Gatsogiannis, C, Efremov, R.G, Lang, A.E, Hofnagel, O, Vetter, I.R, Aktories, K, Raunser, S. | | Deposit date: | 2014-01-03 | | Release date: | 2014-02-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Mechanism of Tc toxin action revealed in molecular detail.
Nature, 508, 2014
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4QNQ
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4QAM
 | | Crystal Structure of the RPGR RCC1-like domain in complex with the RPGR-interacting domain of RPGRIP1 | | Descriptor: | GLYCEROL, MAGNESIUM ION, X-linked retinitis pigmentosa GTPase regulator, ... | | Authors: | Remans, K, Buerger, M, Vetter, I.R, Wittinghofer, A. | | Deposit date: | 2014-05-05 | | Release date: | 2014-07-30 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | C2 domains as protein-protein interaction modules in the ciliary transition zone.
Cell Rep, 8, 2014
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1YRG
 | | THE CRYSTAL STRUCTURE OF RNA1P: A NEW FOLD FOR A GTPASE-ACTIVATING PROTEIN | | Descriptor: | GTPASE-ACTIVATING PROTEIN RNA1_SCHPO | | Authors: | Hillig, R.C, Renault, L, Vetter, I.R, Drell, T, Wittinghofer, A, Becker, J. | | Deposit date: | 1999-03-29 | | Release date: | 2000-03-29 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | The crystal structure of rna1p: a new fold for a GTPase-activating protein.
Mol.Cell, 3, 1999
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1XZP
 | | Structure of the GTP-binding protein TrmE from Thermotoga maritima | | Descriptor: | Probable tRNA modification GTPase trmE, SULFATE ION | | Authors: | Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A. | | Deposit date: | 2004-11-12 | | Release date: | 2005-01-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of the TrmE GTP-binding protein and its implications for tRNA modification
Embo J., 24, 2005
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1XZQ
 | | Structure of the GTP-binding protein TrmE from Thermotoga maritima complexed with 5-formyl-THF | | Descriptor: | N-{[4-({[(6R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)phenyl]carbonyl}-L-glutamic acid, Probable tRNA modification GTPase trmE | | Authors: | Scrima, A, Vetter, I.R, Armengod, M.E, Wittinghofer, A. | | Deposit date: | 2004-11-12 | | Release date: | 2005-01-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The structure of the TrmE GTP-binding protein and its implications for tRNA modification
Embo J., 24, 2005
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1IAQ
 | | C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1 | | Authors: | Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A. | | Deposit date: | 2001-03-23 | | Release date: | 2001-06-06 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Dynamic properties of the Ras switch I region and its importance for binding to effectors.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1SRQ
 | | Crystal Structure of the Rap1GAP catalytic domain | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GTPase-activating protein 1, SULFATE ION | | Authors: | Daumke, O, Weyand, M, Chakrabarti, P.P, Vetter, I.R, Wittinghofer, A. | | Deposit date: | 2004-03-23 | | Release date: | 2004-05-25 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The GTPase activating protein Rap1GAP uses a catalytic asparagine
Nature, 429, 2004
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1S1C
 | | Crystal structure of the complex between the human RhoA and Rho-binding domain of human ROCKI | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Rho-associated, ... | | Authors: | Dvorsky, R, Blumenstein, L, Vetter, I.R, Ahmadian, M.R. | | Deposit date: | 2004-01-06 | | Release date: | 2004-02-10 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Insights into the Interaction of ROCKI with the Switch Regions of RhoA.
J.Biol.Chem., 279, 2004
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3T1Q
 | | MglA bound to GppNHp in complex with MglB | | Descriptor: | Gliding protein MglB, Gliding protein mglA, MAGNESIUM ION, ... | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1T
 | | MglA bound to GDP in P1 tetrameric arrangement | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2011-11-02 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1X
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3T1S
 | | MglB Homodimer | | Descriptor: | Gliding protein MglB | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1O
 | | MglA bound to GDP | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA, ... | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1R
 | | MglB with tetrameric arrangement | | Descriptor: | Gliding protein MglB, MAGNESIUM ION | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T1V
 | | MglA bound to GDP in P2(1) tetrameric arrangement | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein mglA | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-22 | | Release date: | 2011-08-31 | | Last modified: | 2011-11-02 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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3T12
 | | MglA in complex with MglB in transition state | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Gliding protein MglB, Gliding protein mglA, ... | | Authors: | Miertzschke, M, Vetter, I.R, Koerner, C, Wittinghofer, A. | | Deposit date: | 2011-07-21 | | Release date: | 2011-08-31 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Embo J., 30, 2011
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1V9D
 | | Crystal structure of the core FH2 domain of mouse mDia1 | | Descriptor: | Diaphanous protein homolog 1, SULFATE ION | | Authors: | Shimada, A, Nyitrai, M, Vetter, I.R, Kuhlmann, D, Bugyi, B, Narumiya, S, Geeves, M.A, Wittinghofer, A. | | Deposit date: | 2004-01-24 | | Release date: | 2004-03-09 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The core FH2 domain of diaphanous-related formins is an elongated actin binding protein that inhibits polymerization.
Mol.Cell, 13, 2004
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4F1O
 | | Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp | | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4 | | Authors: | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | | Deposit date: | 2012-05-07 | | Release date: | 2012-06-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4F1T
 | | Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152 | | Descriptor: | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Serine/threonine-protein kinase roco4 | | Authors: | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | | Deposit date: | 2012-05-07 | | Release date: | 2012-06-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations.
Proc.Natl.Acad.Sci.USA, 109, 2012
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