6O66
 
 | |
6O4W
 | | Binary complex of native hAChE with Donepezil | | 分子名称: | 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Gerlits, O, Kovalevsky, A, Radic, Z. | | 登録日 | 2019-03-01 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.
Chem.Biol.Interact., 309, 2019
|
|
6O52
 | |
6O5R
 | |
6O50
 | | Binary complex of native hAChE with BW284c51 | | 分子名称: | 4-(5-{4-[DIMETHYL(PROP-2-ENYL)AMMONIO]PHENYL}-3-OXOPENTYL)-N,N-DIMETHYL-N-PROP-2-ENYLBENZENAMINIUM, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Gerlits, O, Kovalevsky, A, Radic, Z. | | 登録日 | 2019-03-01 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.352 Å) | | 主引用文献 | A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.
Chem.Biol.Interact., 309, 2019
|
|
6O4X
 | | Binary complex of native hAChE with 9-aminoacridine | | 分子名称: | 9-AMINOACRIDINE, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Gerlits, O, Kovalevsky, A, Radic, Z. | | 登録日 | 2019-03-01 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies.
Chem.Biol.Interact., 309, 2019
|
|
6O5S
 | |
3C84
 | | Crystal structure of a complex of AChBP from aplysia californica and the neonicotinoid thiacloprid | | 分子名称: | ISOPROPYL ALCOHOL, MAGNESIUM ION, Soluble acetylcholine receptor, ... | | 著者 | Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. | | 登録日 | 2008-02-08 | | 公開日 | 2008-05-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
3C79
 | | Crystal structure of Aplysia californica AChBP in complex with the neonicotinoid imidacloprid | | 分子名称: | (2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine, ISOPROPYL ALCOHOL, Soluble acetylcholine receptor | | 著者 | Talley, T.T, Harel, M, Hibbs, R.E, Tomizawa, M, Casida, J.E, Taylor, P.W. | | 登録日 | 2008-02-06 | | 公開日 | 2008-05-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore.
Proc.Natl.Acad.Sci.Usa, 105, 2008
|
|
6U34
 | | Binary complex of native hAChE with oxime reactivator RS194B | | 分子名称: | (2E)-N-[2-(azepan-1-yl)ethyl]-2-(hydroxyimino)acetamide, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2019-08-21 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J.Biol.Chem., 295, 2020
|
|
6U37
 | | Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B | | 分子名称: | (2E)-N-[2-(azepan-1-yl)ethyl]-2-(hydroxyimino)acetamide, Acetylcholinesterase, GLYCEROL, ... | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2019-08-21 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J.Biol.Chem., 295, 2020
|
|
6U3P
 | | Binary complex of native hAChE with oxime reactivator LG-703 | | 分子名称: | (2E,2'E)-N,N'-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide], Acetylcholinesterase, DIMETHYL SULFOXIDE | | 著者 | Kovalevsky, A, Gerlits, O, Radic, Z. | | 登録日 | 2019-08-22 | | 公開日 | 2020-02-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.
J.Biol.Chem., 295, 2020
|
|
3SH1
 | | Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nemecz, A, Taylor, P.W. | | 登録日 | 2011-06-15 | | 公開日 | 2011-10-26 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Creating an alpha-7 nicotinic acetylcholine recognition domain from the
acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
|
|
3SIO
 | | Ac-AChBP ligand binding domain (not including beta 9-10 linker) mutated to human alpha-7 nAChR | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nemecz, A, Taylor, P.W. | | 登録日 | 2011-06-19 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | | 主引用文献 | Creating an alpha-7 nicotinic acetylcholine recognition domain from the
acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
|
|
2ACE
 | | NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA | | 分子名称: | ACETYLCHOLINE, ACETYLCHOLINESTERASE | | 著者 | Harel, M, Raves, M.L, Silman, I, Sussman, J.L. | | 登録日 | 1996-06-23 | | 公開日 | 1996-11-08 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nat.Struct.Biol., 4, 1997
|
|
3T4M
 | | Ac-AChBP ligand binding domain mutated to human alpha-7 nAChR (intermediate) | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Nemecz, A, Taylor, P.W. | | 登録日 | 2011-07-26 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Creating an alpha-7 nicotinic acetylcholine recognition domain from the
acetylcholine binding protein: crystallographic and ligand selectivity analyses
J.Biol.Chem., 286, 2011
|
|
2IGU
 | | Deamidated analogue of ImI Conotoxin | | 分子名称: | Alpha-conotoxin ImI | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-25 | | 公開日 | 2007-08-14 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IH6
 | | Pro6 variant of CMrVIA conotoxin | | 分子名称: | Lambda-conotoxin CMrVIA | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-26 | | 公開日 | 2007-08-14 | | 最終更新日 | 2020-06-24 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IHA
 | | Amidated variant of CMrVIA conotoxin | | 分子名称: | Lambda-conotoxin CMrVIA | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-26 | | 公開日 | 2007-08-14 | | 最終更新日 | 2020-06-24 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IFI
 | | Ala6 Variant of ImI Conotoxin | | 分子名称: | Alpha-conotoxin ImI | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-21 | | 公開日 | 2007-08-14 | | 最終更新日 | 2020-06-24 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IFZ
 | | Lys6 Variant of ImI Conotoxin | | 分子名称: | Alpha-conotoxin ImI | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-22 | | 公開日 | 2007-08-14 | | 最終更新日 | 2020-06-24 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IH7
 | | Amidated Pro6 Analogue of CMrVIA conotoxin | | 分子名称: | Lambda-conotoxin CMrVIA | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-26 | | 公開日 | 2007-08-14 | | 最終更新日 | 2020-06-24 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
2IFJ
 | | Lys6 deamidated variant of ImI conotoxin | | 分子名称: | Alpha-conotoxin ImI | | 著者 | Kini, R.M, Kang, T.S. | | 登録日 | 2006-09-21 | | 公開日 | 2007-08-14 | | 最終更新日 | 2022-03-09 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Protein folding determinants: structural features determining alternative disulfide pairing in alpha- and chi/lambda-conotoxins
Biochemistry, 46, 2007
|
|
4NUN
 | | Crystal structure of copper-bound Na-ASP-2 | | 分子名称: | Ancylostoma secreted protein 2, COPPER (II) ION | | 著者 | Hofmann, A. | | 登録日 | 2013-12-03 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Probing the equatorial groove of the hookworm protein and vaccine candidate antigen, Na-ASP-2.
Int.J.Biochem.Cell Biol., 50, 2014
|
|
4NUO
 | | Crystal structure of zinc-bound Na-ASP-2 | | 分子名称: | Ancylostoma secreted protein 2, ZINC ION | | 著者 | Hofmann, A. | | 登録日 | 2013-12-03 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Probing the equatorial groove of the hookworm protein and vaccine candidate antigen, Na-ASP-2.
Int.J.Biochem.Cell Biol., 50, 2014
|
|
