3SIO

Ac-AChBP ligand binding domain (not including beta 9-10 linker) mutated to human alpha-7 nAChR

Summary for 3SIO

• Entry DOI: 10.2210/pdb3sio/pdb
• Related: 2BYR 3SH1 3T4M
• Descriptor: Soluble acetylcholine receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: mutated acetylcholine binding protein, aplysia californica, alpha-7 human nicotinic acetylcholine receptor, achbp, nachr, binding protein, acetylcholine, glycosylation, receptor, methyllycaconitine
• Biological source: Aplysia californica (California sea hare)
• Total number of polymer chains: 10
• Total formula weight: 277709.07

Authors

Nemecz, A.,Taylor, P.W. (deposition date: 2011-06-19, release date: 2011-10-26, Last modification date: 2024-04-03)

• Primary citation: Nemecz, A.,Taylor, P.; Creating an alpha-7 nicotinic acetylcholine recognition domain from the acetylcholine binding protein: crystallographic and ligand selectivity analyses; J.Biol.Chem., 286:42555-42565, 2011; PubMed: 22009746; DOI: 10.1074/jbc.M111.286583

Experimental method

X-RAY DIFFRACTION (2.32 Å)