6U3P

Binary complex of native hAChE with oxime reactivator LG-703

Summary for 6U3P

• Entry DOI: 10.2210/pdb6u3p/pdb
• Descriptor: Acetylcholinesterase, (2E,2'E)-N,N'-[1,4-diazepane-1,4-diyldi(ethane-2,1-diyl)]bis[2-(hydroxyimino)acetamide], DIMETHYL SULFOXIDE, ... (4 entities in total)
• Functional Keywords: reactivator complex, bis-oxime, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 120982.45

Authors

Kovalevsky, A.,Gerlits, O.,Radic, Z. (deposition date: 2019-08-22, release date: 2020-02-12, Last modification date: 2023-10-11)

• Primary citation: Gorecki, L.,Gerlits, O.,Kong, X.,Cheng, X.,Blumenthal, D.K.,Taylor, P.,Ballatore, C.,Kovalevsky, A.,Radic, Z.; Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase.; J.Biol.Chem., 295:4079-4092, 2020; PubMed: 32019865; DOI: 10.1074/jbc.RA119.012400

Experimental method

X-RAY DIFFRACTION (3 Å)