5PTP
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6NNR
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![BU of 6nnr by Molmil](/molmil-images/mine/6nnr) | high-resolution structure of wild-type E. coli thymidylate synthase | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Stroud, R.M, Finer-Moore, J. | Deposit date: | 2019-01-15 | Release date: | 2019-01-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. J. Am. Chem. Soc., 135, 2013
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3E2J
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7SP5
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![BU of 7sp5 by Molmil](/molmil-images/mine/7sp5) | Crystal Structure of a Eukaryotic Phosphate Transporter | Descriptor: | PHOSPHATE ION, Phosphate transporter, nonyl beta-D-glucopyranoside | Authors: | Stroud, R.M, Pedersen, B.P, Kumar, H, Waight, A.B, Risenmay, A.J, Roe-Zurz, Z, Chau, B.H, Schlessinger, A, Bonomi, M, Harries, W, Sali, A, Johri, A.K, Finer-Moore, J. | Deposit date: | 2021-11-02 | Release date: | 2021-11-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a eukaryotic phosphate transporter. Nature, 496, 2013
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1BTX
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1BTZ
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1BTY
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1BTW
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3E3Z
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![BU of 3e3z by Molmil](/molmil-images/mine/3e3z) | Crystal structure of bovine coupling Factor B bound with phenylarsine oxide | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP synthase subunit s, mitochondrial, ... | Authors: | Stroud, R.M, Lee, J.K, Belogrudov, G.I. | Deposit date: | 2008-08-08 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of bovine mitochondrial factor B at 0.96-A resolution. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3E4G
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![BU of 3e4g by Molmil](/molmil-images/mine/3e4g) | Crystal structure of bovine coupling Factor B, G28E mutant | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ATP synthase subunit s, mitochondrial, ... | Authors: | Stroud, R.M, Lee, J.K, Belogrudov, G.I. | Deposit date: | 2008-08-11 | Release date: | 2008-08-26 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.96 Å) | Cite: | Crystal structure of bovine mitochondrial factor B at 0.96-A resolution. Proc.Natl.Acad.Sci.Usa, 105, 2008
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1CN4
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2TRM
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1DPO
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![BU of 1dpo by Molmil](/molmil-images/mine/1dpo) | STRUCTURE OF RAT TRYPSIN | Descriptor: | BENZAMIDINE, CALCIUM ION, SULFATE ION, ... | Authors: | Stroud, R.M. | Deposit date: | 1997-03-31 | Release date: | 1997-07-07 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | 1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures. Proteins, 10, 1991
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8ICD
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![BU of 8icd by Molmil](/molmil-images/mine/8icd) | REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE | Descriptor: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION | Authors: | Hurley, J.H, Dean, A.M, Sohl, J.L, Koshlandjunior, D.E, Stroud, R.M. | Deposit date: | 1990-05-30 | Release date: | 1991-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Regulation of an enzyme by phosphorylation at the active site. Science, 249, 1990
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9ICD
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![BU of 9icd by Molmil](/molmil-images/mine/9icd) | CATALYTIC MECHANISM OF NADP+-DEPENDENT ISOCITRATE DEHYDROGENASE: IMPLICATIONS FROM THE STRUCTURES OF MAGNESIUM-ISOCITRATE AND NADP+ COMPLEXES | Descriptor: | ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Hurley, J.H, Dean, A.M, Koshland Jr, D.E, Stroud, R.M. | Deposit date: | 1991-07-29 | Release date: | 1991-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Catalytic mechanism of NADP(+)-dependent isocitrate dehydrogenase: implications from the structures of magnesium-isocitrate and NADP+ complexes. Biochemistry, 30, 1991
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6ICD
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![BU of 6icd by Molmil](/molmil-images/mine/6icd) | REGULATION OF AN ENZYME BY PHOSPHORYLATION AT THE ACTIVE SITE | Descriptor: | ISOCITRATE DEHYDROGENASE | Authors: | Hurley, J.H, Dean, A.M, Sohl, J.L, Koshlandjunior, D.E, Stroud, R.M. | Deposit date: | 1990-05-30 | Release date: | 1991-10-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Regulation of an enzyme by phosphorylation at the active site. Science, 249, 1990
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1JMF
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1JMH
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1JMI
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8FVZ
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![BU of 8fvz by Molmil](/molmil-images/mine/8fvz) | PiPT Y150A | Descriptor: | CITRATE ANION, PHOSPHATE ION, Phosphate transporter | Authors: | Gupta, M, Finer-Moore, J, Stroud, R.M. | Deposit date: | 2023-01-20 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Roles of PiPT residues in phosphate binding and transport tested by mutagenesis To be published
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3NG1
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![BU of 3ng1 by Molmil](/molmil-images/mine/3ng1) | N AND GTPASE DOMAINS OF THE SIGNAL SEQUENCE RECOGNITION PROTEIN FFH FROM THERMUS AQUATICUS | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, SIGNAL SEQUENCE RECOGNITION PROTEIN FFH, ... | Authors: | Freymann, D.M, Stroud, R.M, Walter, P. | Deposit date: | 1998-09-13 | Release date: | 1999-07-30 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP. Nat.Struct.Biol., 6, 1999
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4E28
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![BU of 4e28 by Molmil](/molmil-images/mine/4e28) | Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor | Descriptor: | 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ... | Authors: | Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P. | Deposit date: | 2012-03-07 | Release date: | 2012-11-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J.Med.Chem., 55, 2012
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7TDF
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![BU of 7tdf by Molmil](/molmil-images/mine/7tdf) | AtTPC1 D454N with 1 mM EDTA state I | Descriptor: | Two pore calcium channel protein 1 | Authors: | Dickinson, M.S, Stroud, R.M. | Deposit date: | 2021-12-31 | Release date: | 2022-02-02 | Last modified: | 2022-03-09 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis of multistep voltage activation in plant two-pore channel 1. Proc.Natl.Acad.Sci.USA, 119, 2022
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1YMG
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![BU of 1ymg by Molmil](/molmil-images/mine/1ymg) | The Channel Architecture of Aquaporin O at 2.2 Angstrom Resolution | Descriptor: | Lens fiber major intrinsic protein, nonyl beta-D-glucopyranoside | Authors: | Harries, W.E.C, Akhavan, D, Miercke, L.J.W, Khademi, S, Stroud, R.M. | Deposit date: | 2005-01-20 | Release date: | 2005-02-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | The Channel Architecture of Aquaporin 0 at a 2.2-A Resolution Proc.Natl.Acad.Sci.USA, 101, 2004
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1JUJ
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![BU of 1juj by Molmil](/molmil-images/mine/1juj) | Human Thymidylate Synthase Bound to dUMP and LY231514, a Pyrrolo(2,3-d)pyrimidine-based Antifolate | Descriptor: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, THYMIDYLATE SYNTHASE | Authors: | Sayre, P.H, Finer-Moore, J.S, Fritz, T.A, Biermann, D, Gates, S.B, MacKellar, W.C, Patel, V.F, Stroud, R.M. | Deposit date: | 2001-08-24 | Release date: | 2001-09-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. J.Mol.Biol., 313, 2001
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