6DG2
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6EA7
| Structure of EBOV GPcl in complex with the pan-ebolavirus mAb ADI-15878 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | West, B.R, Moyer, C.L, King, L.B, Fusco, M.L, Milligan, J.C, Hui, S, Saphire, E.O. | Deposit date: | 2018-08-02 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.25 Å) | Cite: | Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. MBio, 9, 2018
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6EB9
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6EB8
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6EA5
| Structure of BDBV GPcl in complex with the pan-ebolavirus mAb ADI-15878 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-15878 Fab Heavy Chain, ... | Authors: | King, L.B, West, B.R, Moyer, C.L, Fusco, M.L, Milligan, J.C, Hui, S, Saphire, E.O. | Deposit date: | 2018-08-02 | Release date: | 2018-09-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.75 Å) | Cite: | Structural Basis of Pan-Ebolavirus Neutralization by a Human Antibody against a Conserved, yet Cryptic Epitope. MBio, 9, 2018
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4FVU
| Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease | Descriptor: | MAGNESIUM ION, Nucleoprotein, RNA (5'-R(*CP*UP*CP*CP*CP*UP*CP*C)-3'), ... | Authors: | Hastie, K.M, King, L.B, Zandonatti, M.A, Saphire, E.O. | Deposit date: | 2012-06-29 | Release date: | 2012-09-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease. Plos One, 7, 2012
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4GHA
| Crystal structure of Marburg virus VP35 RNA binding domain bound to 12-bp dsRNA | Descriptor: | Polymerase cofactor VP35, RNA (5'-R(*CP*UP*AP*GP*AP*CP*GP*UP*CP*UP*AP*G)-3') | Authors: | Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O. | Deposit date: | 2012-08-07 | Release date: | 2012-08-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8, 2012
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4GH9
| Crystal structure of Marburg virus VP35 RNA binding domain | Descriptor: | ACETATE ION, Polymerase cofactor VP35 | Authors: | Bale, S, Jean-Philippe, J, Bornholdt, Z.A, Kimberlin, C.K, Halfmann, P, Zandonatti, M.A, Kunert, J, Kroon, G.J.A, Kawaoka, Y, MacRae, I.J, Wilson, I.A, Saphire, E.O. | Deposit date: | 2012-08-07 | Release date: | 2012-08-15 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Marburg Virus VP35 Can Both Fully Coat the Backbone and Cap the Ends of dsRNA for Interferon Antagonism. Plos Pathog., 8, 2012
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4ZTG
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4ZTI
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4ZTA
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6MAM
| Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 | Descriptor: | ADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ... | Authors: | West, B.R, Moyer, C.L, Fusco, M.L, Saphire, E.O. | Deposit date: | 2018-08-28 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural basis of broad ebolavirus neutralization by a human survivor antibody. Nat. Struct. Mol. Biol., 26, 2019
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6N7U
| apo-BDBV223 Fab | Descriptor: | BDBV223 antibody heavy chain, BDBV223 antibody light chain | Authors: | King, L.B, West, B.R, Saphire, E.O. | Deposit date: | 2018-11-28 | Release date: | 2019-03-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk. Nat Commun, 10, 2019
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6N7J
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6BP2
| Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | Deposit date: | 2017-11-21 | Release date: | 2018-01-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.172 Å) | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding. Cell Host Microbe, 23, 2018
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7U9G
| Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein, RVA122 Fab Heavy Chain, ... | Authors: | Callaway, H.M, Zyla, D, Larrous, F, Dias de Melo, G, Hastie, K.M, Avalos, R.D, Agarwal, A, Bouhry, H, Corti, D, Saphire, E.O. | Deposit date: | 2022-03-10 | Release date: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.39 Å) | Cite: | Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Sci Adv, 8, 2022
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7TN9
| Structure of the Inmazeb cocktail and resistance to escape against Ebola virus | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, GP2, ... | Authors: | Rayaprolu, V, Fulton, B, Rafique, A, Arturo, E, Williams, D, Hariharan, C, Callaway, H, Parvate, A, Schendel, S.L, Parekh, D, Hui, S, Shaffer, K, Pascal, K.E, Wloga, E, Giordano, S, Copin, R, Franklin, M, Boytz, R.M, Donahue, C, Davey, R, Baum, A, Kyratsous, C.A, Saphire, E.O. | Deposit date: | 2022-01-20 | Release date: | 2023-01-25 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the Inmazeb cocktail and resistance to Ebola virus escape. Cell Host Microbe, 31, 2023
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7UOV
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7UOT
| Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 37.2D heavy chain (variable domain), ... | Authors: | Li, H, Saphire, E.O. | Deposit date: | 2022-04-13 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus. Sci Transl Med, 14, 2022
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5T3W
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8DMH
| Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 | Descriptor: | 18.5C-M28 Fab Heavy Chain, 18.5C-M28 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | Deposit date: | 2022-07-08 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol, 30, 2023
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8DMI
| Lymphocytic choriomeningitis virus glycoprotein | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein G1, ... | Authors: | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | Deposit date: | 2022-07-08 | Release date: | 2023-04-12 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus. Cell Chem Biol, 30, 2023
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8DPL
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8DPM
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5T3T
| Ebola virus VP30 CTD bound to nucleoprotein | Descriptor: | Fusion protein of Nucleoprotein and Minor nucleoprotein VP30, SULFATE ION | Authors: | Kirchdoerfer, R.N, Moyer, C.L, Abelson, D.M, Saphire, E.O. | Deposit date: | 2016-08-26 | Release date: | 2016-09-28 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Ebola Virus VP30-NP Interaction Is a Regulator of Viral RNA Synthesis. Plos Pathog., 12, 2016
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