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2IFB
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BU of 2ifb by Molmil
CRYSTAL STRUCTURE OF RAT INTESTINAL FATTY-ACID-BINDING PROTEIN. REFINEMENT AND ANALYSIS OF THE ESCHERICHIA COLI-DRIVED PROTEIN WITH BOUND PALMITATE
分子名称: INTESTINAL FATTY ACID BINDING PROTEIN, PALMITIC ACID
著者Sacchettini, J.C, Gordon, J.I, Banaszak, L.J.
登録日1990-12-05
公開日1992-01-15
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of rat intestinal fatty-acid-binding protein. Refinement and analysis of the Escherichia coli-derived protein with bound palmitate.
J.Mol.Biol., 208, 1989
1IFB
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BU of 1ifb by Molmil
REFINED APOPROTEIN STRUCTURE OF RAT INTESTINAL FATTY ACID BINDING PROTEIN PRODUCED IN ESCHERICHIA COLI
分子名称: INTESTINAL FATTY ACID BINDING PROTEIN
著者Sacchettini, J.C, Gordon, J.I, Banaszak, L.J.
登録日1990-12-05
公開日1992-01-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Refined apoprotein structure of rat intestinal fatty acid binding protein produced in Escherichia coli.
Proc.Natl.Acad.Sci.USA, 86, 1989
3OKR
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BU of 3okr by Molmil
Structure of Mtb apo 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD)
分子名称: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, Heptamer peptide
著者Sacchettini, J.C, Reddy, M.C.M, Bruning, J.B, Thurman, C, TB Structural Genomics Consortium (TBSGC)
登録日2010-08-25
公開日2010-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of the Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): an antitubercular drug target
To be Published
5KVU
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BU of 5kvu by Molmil
Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from Mycobacterium tuberculosis
分子名称: 1,2-ETHANEDIOL, D-MALATE, GLYCEROL, ...
著者Cheng, Y.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2016-07-15
公開日2017-07-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.66 Å)
主引用文献Structural and kinetic characterization of isocitrate dehydrogenase-2 from Mycobacterium tuberculosis
To Be Published
4XT8
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BU of 4xt8 by Molmil
Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimetrexate
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-01-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT7
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Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimethoprim
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-01-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT6
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Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with the tetrahydropteridine ring of tetrahydrofolate (THF)
分子名称: (6S)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671
著者Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-01-23
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT5
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Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+
分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671
著者Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-01-22
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
4XT4
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BU of 4xt4 by Molmil
Crystal structure of Rv2671 from Mycobacteirum tuberculosis in complex with dihydropteridine ring of dihydropteroic acid
分子名称: 2-amino-6-methyl-7,8-dihydropteridin-4(3H)-one, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
登録日2015-01-22
公開日2016-02-24
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.891 Å)
主引用文献Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
3F4B
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BU of 3f4b by Molmil
Crystal structure of Plasmodium berghei Enoyl-acyl-carrier-protein reductase with TRICLOSAN
分子名称: Enoyl-acyl carrier protein reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN
著者Sacchettini, J.C, Tsai, H.-C.
登録日2008-10-31
公開日2010-03-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites.
Cell Host Microbe, 4, 2008
2HH7
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BU of 2hh7 by Molmil
Crystal Structure of Cu(I) bound CsoR from Mycobacterium tuberculosis.
分子名称: COPPER (I) ION, Hypothetical protein CsoR
著者Sacchettini, J.C, Ramesh, A.
登録日2006-06-27
公開日2006-12-05
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator.
Nat.Chem.Biol., 3, 2007
1M1M
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BU of 1m1m by Molmil
X-RAY CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS BETA-KETOACYL-ACYL CARRIER PROTEIN SYNTHASE III (MTFABH)
分子名称: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III
著者Sacchettini, J.C, Sridharan, S, TB Structural Genomics Consortium (TBSGC)
登録日2002-06-19
公開日2002-07-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.
J.Biol.Chem., 280, 2005
8GKF
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BU of 8gkf by Molmil
Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
分子名称: 4'-phosphopantetheinyl transferase PptT, TOMUDEX
著者Krieger, I.V, Singh, A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2023-03-18
公開日2024-03-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv, 10, 2024
6MJ1
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BU of 6mj1 by Molmil
Crystal structure of RefZ (regulator of FtsZ) from Bacillus subtilis
分子名称: Probable HTH-type transcriptional regulator YttP
著者Krieger, I.V, Brown, E.E, Herman, J.K, Sacchettini, J.C.
登録日2018-09-20
公開日2019-03-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A DNA-Binding Protein Tunes Septum Placement during Bacillus subtilis Sporulation.
J.Bacteriol., 201, 2019
8SKY
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BU of 8sky by Molmil
Crystal structure of YisK from Bacillus subtilis in complex with oxalate
分子名称: Fumarylacetoacetate hydrolase family protein, MANGANESE (II) ION, OXALATE ION
著者Krieger, I.V, Chemelewski, V, Guo, T, Sperber, A, Herman, J, Sacchettini, J.C.
登録日2023-04-20
公開日2023-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization.
J.Bacteriol., 206, 2024
8SUU
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Crystal structure of YisK from Bacillus subtilis in apo form
分子名称: Fumarylacetoacetate hydrolase family protein, MANGANESE (II) ION
著者Krieger, I.V, Chemelewski, V, Guo, T, Sperber, A, Herman, J, Sacchettini, J.C.
登録日2023-05-13
公開日2023-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization.
J.Bacteriol., 206, 2024
8SUT
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BU of 8sut by Molmil
Crystal structure of YisK from Bacillus subtilis in complex with reaction product 4-Hydroxy-2-oxoglutaric acid
分子名称: (2~{R})-2-oxidanyl-4-oxidanylidene-pentanedioic acid, Fumarylacetoacetate hydrolase family protein, MANGANESE (II) ION
著者Krieger, I.V, Chemelewski, V, Guo, T, Sperber, A, Herman, J, Sacchettini, J.C.
登録日2023-05-13
公開日2023-11-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Bacillus subtilis YisK possesses oxaloacetate decarboxylase activity and exhibits Mbl-dependent localization.
J.Bacteriol., 206, 2024
7SVT
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BU of 7svt by Molmil
Mycobacterium tuberculosis 3-hydroxyl-ACP dehydratase HadAB in complex with 1,3-diarylpyrazolyl-acylsulfonamide inhibitor
分子名称: (3R)-hydroxyacyl-ACP dehydratase subunit HadB, 1,2-ETHANEDIOL, 3-[1-(4-bromophenyl)-3-(4-chlorophenyl)-1H-pyrazol-4-yl]-N-(methanesulfonyl)propanamide, ...
著者Krieger, I.V, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2021-11-19
公開日2022-11-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis .
Acs Infect Dis., 8, 2022
5H8P
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Crystal structure of Mycobacterium tuberculosis malate synthase in apo form
分子名称: Malate synthase G
著者Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
登録日2015-12-23
公開日2016-10-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.105 Å)
主引用文献Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5H8M
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Crystal structure of Mycobacterium tuberculosis malate synthase C619A, G459A mutant in complex with product malate
分子名称: (2S)-2-hydroxybutanedioic acid, MAGNESIUM ION, Malate synthase G
著者Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
登録日2015-12-23
公開日2016-10-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
5H8U
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Crystal structure of mycobacterium tuberculosis wild-type malate synthase in complex with product malate
分子名称: (2S)-2-hydroxybutanedioic acid, GLYOXYLIC ACID, MAGNESIUM ION, ...
著者Krieger, I.V, Huang, H.-L, Sacchettini, J.C.
登録日2015-12-23
公開日2016-10-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.
J. Biol. Chem., 291, 2016
4WIE
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BU of 4wie by Molmil
Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol
分子名称: GLYCEROL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase [GTP]
著者Kim, H.L, Sacchettini, J.C.
登録日2014-09-25
公開日2014-10-22
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol
To Be Published
4WPV
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BU of 4wpv by Molmil
Crystal Structure of E83A mutant of Mtb PEPCK in complex with Zn2+ and phosphate ion
分子名称: GLYCEROL, PHOSPHATE ION, Phosphoenolpyruvate carboxykinase [GTP], ...
著者Kim, H.L, Sacchettini, J.C.
登録日2014-10-21
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.672 Å)
主引用文献Crystal Structure of E83A from Mtb PEPCK in complex with Zn2+ and phosphate ion
To Be Published
4WPT
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BU of 4wpt by Molmil
Crystal Structure of Mtb PEPCK in complex with PEP
分子名称: GLYCEROL, PHOSPHATE ION, PHOSPHOENOLPYRUVATE, ...
著者Kim, H.L, Krieger, I.V, Sacchettini, J.C.
登録日2014-10-21
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Mtb PEPCK in complex with PEP
To Be Published
6PX4
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Crystal structure of the complex between periplasmic domains of antiholin RI and holin T from T4 phage, in H32
分子名称: Antiholin, Holin
著者Krieger, I.V, Sacchettini, J.C.
登録日2019-07-24
公開日2020-06-24
最終更新日2020-08-12
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The Structural Basis of T4 Phage Lysis Control: DNA as the Signal for Lysis Inhibition.
J.Mol.Biol., 432, 2020

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