7QEF
| Crystal structure of para-nitrophenyl-Beta-D-glucuronide bound to a mutant of SN243 (D415A) | 分子名称: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, ACETATE ION, SN243, ... | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | 登録日 | 2021-12-02 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
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7QE1
| Crystal structure of apo SN243 | 分子名称: | SN243, ZINC ION | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | 登録日 | 2021-12-01 | 公開日 | 2022-10-12 | 最終更新日 | 2023-03-29 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
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7QE2
| Crystal structure of D-glucuronic acid bound to SN243 | 分子名称: | ACETATE ION, SN243, SULFATE ION, ... | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | 登録日 | 2021-12-01 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
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7QG4
| Apo crystal structure of a mutant of SN243 (D415N) | 分子名称: | SN243, SULFATE ION, ZINC ION | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | 登録日 | 2021-12-07 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
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7QEE
| SN243 mutant D415N bound to para-nitrophenyl-Beta-D-glucuronide | 分子名称: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, SN243, SULFATE ION, ... | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | 登録日 | 2021-12-02 | 公開日 | 2022-11-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.374 Å) | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase. Nat.Chem.Biol., 18, 2022
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6QGI
| Crystal structure of VP5 from Haloarchaeal pleomorphic virus 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, VP5 | 著者 | El Omari, K, Walter, T.S, Harlos, K, Grimes, J.M, Stuart, D.I, Roine, E. | 登録日 | 2019-01-11 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun, 10, 2019
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6QGL
| Crystal structure of VP5 from Haloarchaeal pleomorphic virus 6 | 分子名称: | BROMIDE ION, VP5 | 著者 | El Omari, K, Walter, T.S, Harlos, K, Grimes, J.M, Stuart, D.I, Roine, E. | 登録日 | 2019-01-11 | 公開日 | 2019-02-27 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins. Nat Commun, 10, 2019
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5MDU
| Structure of the RNA recognition motif (RRM) of Seb1 from S. pombe. | 分子名称: | CHLORIDE ION, GLYCEROL, Rpb7-binding protein seb1, ... | 著者 | Wittmann, S, Renner, M, El Omari, K, Adams, O, Vasiljeva, L, Grimes, J. | 登録日 | 2016-11-13 | 公開日 | 2017-04-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.02 Å) | 主引用文献 | The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA. Nat Commun, 8, 2017
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5MUU
| dsRNA bacteriophage phi6 nucleocapsid | 分子名称: | Major inner protein P1, Major outer capsid protein, Packaging enzyme P4 | 著者 | Sun, Z, El Omari, K, Sun, X, Ilca, S.L, Kotecha, A, Stuart, D.I, Poranen, M.M, Huiskonen, J.T. | 登録日 | 2017-01-14 | 公開日 | 2017-03-22 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Double-stranded RNA virus outer shell assembly by bona fide domain-swapping. Nat Commun, 8, 2017
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2J87
| Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design | 分子名称: | MAGNESIUM ION, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ... | 著者 | El Omari, K, Solaroli, N, Karlsson, A, Balzarini, J, Stammers, D.K. | 登録日 | 2006-10-23 | 公開日 | 2006-11-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design. Bmc Struct.Biol., 6, 2006
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2J0F
| Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design | 分子名称: | THYMIDINE PHOSPHORYLASE, THYMINE | 著者 | El Omari, K, Bronckaers, A, Liekens, S, Perez-Perez, M.J, Balzarini, J, Stammers, D.K. | 登録日 | 2006-08-02 | 公開日 | 2006-10-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design. Biochem.J., 399, 2006
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2J41
| Crystal structure of Staphylococcus aureus guanylate monophosphate kinase | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, GUANYLATE KINASE, POTASSIUM ION, ... | 著者 | El Omari, K, Dhaliwal, B, Lockyer, M, Charles, I, Hawkins, A.R, Stammers, D.K. | 登録日 | 2006-08-24 | 公開日 | 2006-10-11 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of Staphylococcus Aureus Guanylate Monophosphate Kinase Acta Crystallogr.,Sect.F, 62, 2006
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6JJH
| Crystal structure of a two-quartet RNA parallel G-quadruplex complexed with the porphyrin TMPyP4 | 分子名称: | (1Z,4Z,9Z,15Z)-5,10,15,20-tetrakis(1-methylpyridin-1-ium-4-yl)-21,23-dihydroporphyrin, POTASSIUM ION, RNA (5'-R(*GP*GP*CP*UP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3') | 著者 | Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G. | 登録日 | 2019-02-25 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020
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6JJF
| Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*GP*GP*CP*TP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3'), POTASSIUM ION, ... | 著者 | Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G. | 登録日 | 2019-02-25 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020
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7O56
| X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element solved by Phosphorus and Sulphur SAD methods | 分子名称: | DNA (5'-D(P*AP*AP*TP*AP*AP*AP*AP*GP*AP*AP*AP*CP*CP*GP*AP*AP*AP*GP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*AP*CP*TP*TP*TP*CP*GP*GP*TP*TP*TP*CP*TP*TP*TP*TP*AP*T)-3'), Interferon regulatory factor 4 | 著者 | El Omari, K, Agnarelli, A, Duman, R, Wagner, A, Mancini, E.J. | 登録日 | 2021-04-07 | 公開日 | 2021-05-12 | 最終更新日 | 2021-10-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Phosphorus and sulfur SAD phasing of the nucleic acid-bound DNA-binding domain of interferon regulatory factor 4. Acta Crystallogr.,Sect.F, 77, 2021
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7OGS
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7OOT
| X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to an interferon-stimulated response element | 分子名称: | DNA (5'-D(P*AP*GP*CP*TP*TP*TP*CP*TP*CP*GP*GP*TP*TP*TP*CP*AP*GP*TP*TP*G)-3'), DNA (5'-D(P*TP*CP*AP*AP*CP*TP*GP*AP*AP*AP*CP*CP*GP*AP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor 4, ... | 著者 | Agnarelli, A, El Omari, K, Alt, A.O, Mancini, E.J. | 登録日 | 2021-05-28 | 公開日 | 2022-06-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | X-ray Structure of Interferon Regulatory Factor 4 DNA binding domain bound to interferon-stimulated response element To Be Published
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7PGK
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), in complex with glycosaminoglycan mimic SOS | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2021-12-22 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGN
| HHP-C in complex with glycosaminoglycan mimic SOS | 分子名称: | 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGL
| HHIP-N, the N-terminal domain of the Hedgehog-Interacting Protein (HHIP), apo-form | 分子名称: | Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.63 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7PGM
| HHIP-C in complex with heparin | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-3)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Hedgehog-interacting protein | 著者 | Griffiths, S.C, Schwab, R.A, El Omari, K, Bishop, B, Iverson, E.J, Malinuskas, T, Dubey, R, Qian, M, Covey, D.F, Gilbert, R.J.C, Rohatgi, R, Siebold, C. | 登録日 | 2021-08-14 | 公開日 | 2021-12-15 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nat Commun, 12, 2021
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7ACX
| H/L (SLPH/SLPL) complex from C. difficile (R7404 strain) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S-layer protein, SULFATE ION | 著者 | Lanzoni-Mangutchi, P, Barwinska-Sendra, A, Basle, A, El Omari, K, Wagner, A, Salgado, P.S. | 登録日 | 2020-09-11 | 公開日 | 2022-03-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure and assembly of the S-layer in C. difficile. Nat Commun, 13, 2022
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6J7V
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2YQ2
| Structure of BVDV1 envelope glycoprotein E2, pH8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BVDV1 E2 | 著者 | El Omari, K, Iourin, O, Harlos, K, Grimes, J.M, Stuart, D.I. | 登録日 | 2012-11-04 | 公開日 | 2013-01-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies its Role in Cell Entry. Cell Rep., 3, 2013
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2YQ3
| Structure of BVDV1 envelope glycoprotein E2, pH5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BVDV1 E2 | 著者 | El Omari, K, Iourin, O, Harlos, K, Grimes, J.M, Stuart, D.I. | 登録日 | 2012-11-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | 主引用文献 | Structure of a Pestivirus Envelope Glycoprotein E2 Clarifies its Role in Cell Entry. Cell Rep., 3, 2013
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