2J87

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

Summary for 2J87

Entry DOI	10.2210/pdb2j87/pdb
Descriptor	THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION, ... (4 entities in total)
Functional Keywords	type 2 thymidine kinase, dna synthesis, nucleotide-binding, dttp, kinase, transferase, atp-binding, vaccinia virus thymidine kinase
Biological source	VACCINIA VIRUS
Total number of polymer chains	4
Total formula weight	82552.37
Authors	El Omari, K.,Solaroli, N.,Karlsson, A.,Balzarini, J.,Stammers, D.K. (deposition date: 2006-10-23, release date: 2006-11-13, Last modification date: 2024-11-06)
Primary citation	El Omari, K.,Solaroli, N.,Karlsson, A.,Balzarini, J.,Stammers, D.K. Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design. Bmc Struct.Biol., 6:22-, 2006 Cited by PubMed Abstract: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside analogues by virus-encoded thymidine (dThd) kinases (TK) represents one of the most successful strategies for antiviral chemotherapy as demonstrated for anti-herpes drugs. Vaccinia virus TK is a close orthologue of variola TK but also shares a relatively high sequence identity to human type 2 TK (hTK), thus achieving drug selectivity relative to the host enzyme is challenging. PubMed: 17062140 DOI: 10.1186/1472-6807-6-22 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation