2J87
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | THYMIDINE KINASE | polymer | 177 | 20066.2 | 4 | UniProt (O57203) Pfam (PF00265) | VACCINIA VIRUS | VACCINIA VIRUS THYMIDINE KINASE |
| 2 | E, H, K, N (A, B, C, D) | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 4 | Chemie (TTP) | |||
| 3 | F, I, L, O (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | G, J, M, P (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) |
Sequence modifications
A, B, C, D: 1 - 177 (UniProt: O57203)
| PDB | External Database | Details |
|---|---|---|
| Gln 71 | Glu 71 | conflict |
| Leu 125 | Ile 125 | conflict |
| Ile 126 | Pro 126 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 80264.8 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2287.5 | |
| All* | Total formula weight | 82552.4 |
