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E.coli 23S Sarcin-Ricil Loop, modified with a 2-Me on G2661 and a methylphosphonate on A2662
分子名称:	27-mer 23S Sarcin-Ricil Loop
著者	Ennifar, E, Micura, R, Fluer, S.
登録日	2015-02-09
公開日	2015-11-18
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (0.998 Å)
主引用文献	Role of a ribosomal RNA phosphate oxygen during the EF-G-triggered GTP hydrolysis. Proc.Natl.Acad.Sci.USA, 112, 2015

8T8B

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
著者	Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
登録日	2023-06-22
公開日	2023-07-19
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.65 Å)
主引用文献	Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023

8T8C

Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution
分子名称:	(4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
著者	Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
登録日	2023-06-22
公開日	2023-07-19
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023

5NQI

E.coli 16S rRNA Sarcin-Ricin Loop containing a 5-hydroxymethylcytosine modification
分子名称:	E.Coli 27-mer SRL RNA
著者	Ennifar, E, Micura, R.
登録日	2017-04-20
公開日	2017-07-26
最終更新日	2019-10-16
実験手法	X-RAY DIFFRACTION (0.851 Å)
主引用文献	Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine. J. Org. Chem., 82, 2017

6N9E

Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic CC-Pmn and bound to mRNA and P-site tRNA at 3.7A resolution
分子名称:	16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S19, ...
著者	Melnikov, S.V, Khabibullina, N.F, Mairhofer, E, Vargas-Rodriguez, O, Reynolds, N.M, Micura, R, Soll, D, Polikanov, Y.S.
登録日	2018-12-03
公開日	2018-12-12
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (3.7 Å)
主引用文献	Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Res., 47, 2019

6N9F

Crystal structure of the Thermus thermophilus 70S ribosome in complex with a short substrate mimic ACCA-DPhe and bound to mRNA and P-site tRNA at 3.7A resolution
分子名称:	16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S19, ...
著者	Melnikov, S.V, Khabibullina, N.F, Mairhofer, E, Vargas-Rodriguez, O, Reynolds, N.M, Micura, R, Soll, D, Polikanov, Y.S.
登録日	2018-12-03
公開日	2018-12-12
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (3.7 Å)
主引用文献	Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Res., 47, 2019

3S8U

Crystal structure of a 2-azido-adenine-modified RNA
分子名称:	Ecoli 23 S rRNA Sarcin Ricin loop
著者	Ennifar, E, Micura, R.
登録日	2011-05-31
公開日	2012-04-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.2 Å)
主引用文献	2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling. Acs Chem.Biol., 7, 2012

3S7C

Crystal structure of a 2'-azido-uridine-modified RNA
分子名称:	Ecoli 23 S rRNA Sarcin Ricin loop
著者	Ennifar, E, Micura, R.
登録日	2011-05-26
公開日	2012-04-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.1 Å)
主引用文献	2'-Azido RNA, a Versatile Tool for Chemical Biology: Synthesis, X-ray Structure, siRNA Applications, Click Labeling. Acs Chem.Biol., 7, 2012

6UF1

Pistol ribozyme transition-state analog vanadate
分子名称:	MANGANESE (II) ION, RNA (5'-R(UPCPUPGPCPUPCPUPCP(GVA)UPCPCPAP*A)-3'), RNA (50-MER)
著者	Teplova, M, Falschlunger, C, Krasheninina, O, Patel, D.J, Micura, R.
登録日	2019-09-23
公開日	2019-12-18
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme. Angew.Chem.Int.Ed.Engl., 59, 2020

6QIQ

Crystal structure of seleno-derivative CAG repeats with synthetic CMBL3a compound
分子名称:	CMBL3a, RNA (5'-R(GPCPAPG)-D(P(CSL))-R(PAPGPC)-3')
著者	Kiliszek, A, Blaszczyk, L, Rypniewski, W, Micura, R, Nakatani, K.
登録日	2019-01-21
公開日	2019-09-25
最終更新日	2019-11-20
実験手法	X-RAY DIFFRACTION (2.519 Å)
主引用文献	Structural insights into synthetic ligands targeting A-A pairs in disease-related CAG RNA repeats. Nucleic Acids Res., 47, 2019

6UFJ

Pistol ribozyme product crystal structure
分子名称:	MAGNESIUM ION, RNA (5'-R(UPCPCPAPG)-3'), RNA (5'-R(UPCPUPGPCPUPCPUPCP*(23G))-3'), ...
著者	Teplova, M, Falschlunger, C, Krasheninina, O, Patel, D.J, Micura, R.
登録日	2019-09-24
公開日	2019-12-18
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2.645 Å)
主引用文献	Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme. Angew.Chem.Int.Ed.Engl., 59, 2020

6UEY

Pistol ribozyme transition-state analog vanadate
分子名称:	MAGNESIUM ION, RNA (5'-R(UPCPUPGPCPUPCPUPCP(GVA)UPCPCPAP*A)-3'), RNA (50-MER)
著者	Teplova, M, Falschlunger, C, Krasheninina, O, Patel, D.J, Micura, R.
登録日	2019-09-23
公開日	2019-12-18
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme. Angew.Chem.Int.Ed.Engl., 59, 2020

6UFK

Pistol ribozyme product crystal soaked in Mn2+
分子名称:	MANGANESE (II) ION, RNA (5'-R(UPCPCPAPG)-3'), RNA (5'-R(UPCPUPGPCPUPCPUPCP*(23G))-3'), ...
著者	Teplova, M, Falschlunger, C, Krasheninina, O, Patel, D.J, Micura, R.
登録日	2019-09-24
公開日	2019-12-18
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Crucial Roles of Two Hydrated Mg2+Ions in Reaction Catalysis of the Pistol Ribozyme. Angew.Chem.Int.Ed.Engl., 59, 2020

6XUR

RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
分子名称:	MAGNESIUM ION, RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
著者	Ennifar, E, Micura, R, Gasser, C, Brillet, K.
登録日	2020-01-21
公開日	2020-02-19
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.1 Å)
主引用文献	Thioguanosine Conversion Enables mRNA-Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC-seq DUAL). Angew.Chem.Int.Ed.Engl., 59, 2020

6XUS

RNA dodecamer with a 6-hydrazino-2-aminopurine modified base
分子名称:	MAGNESIUM ION, RNA dodecamer with a 6-hydrazino-2-aminopurine modified base, SODIUM ION
著者	Ennifar, E, Micura, R, Gasser, C, Brillet, K.
登録日	2020-01-21
公開日	2021-02-03
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.1 Å)
主引用文献	Thioguanosine Conversion Enables mRNA-Lifetime Evaluation by RNA Sequencing Using Double Metabolic Labeling (TUC-seq DUAL). Angew.Chem.Int.Ed.Engl., 59, 2020

1YKV

Crystal structure of the Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene
分子名称:	(3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, Diels-Alder ribozyme, MAGNESIUM ION
著者	Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
登録日	2005-01-18
公開日	2005-02-22
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005

1YKQ

Crystal structure of Diels-Alder ribozyme
分子名称:	CADMIUM ION, Diels-Alder ribozyme, MAGNESIUM ION
著者	Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
登録日	2005-01-18
公開日	2005-02-22
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (3.5 Å)
主引用文献	Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005

1YLS

Crystal structure of selenium-modified Diels-Alder ribozyme complexed with the product of the reaction between N-pentylmaleimide and covalently attached 9-hydroxymethylanthracene
分子名称:	(3AS,9AS)-2-PENTYL-4-HYDROXYMETHYL-3A,4,9,9A-TETRAHYDRO-4,9[1',2']-BENZENO-1H-BENZ[F]ISOINDOLE-1,3(2H)-DIONE, MAGNESIUM ION, RNA Diels-Alder ribozyme
著者	Serganov, A, Keiper, S, Malinina, L, Tereshko, V, Skripkin, E, Hobartner, C, Polonskaia, A, Phan, A.T, Wombacher, R, Micura, R, Dauter, Z, Jaschke, A, Patel, D.J.
登録日	2005-01-19
公開日	2005-02-22
最終更新日	2024-02-14
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat.Struct.Mol.Biol., 12, 2005

5DAT

Complex of yeast 80S ribosome with hypusine-containing eIF5A
分子名称:	18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
著者	Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
登録日	2015-08-20
公開日	2016-08-31
最終更新日	2024-01-10
実験手法	X-RAY DIFFRACTION (3.15 Å)
主引用文献	Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published

5MRX

27-nt SRL with a 5-hydroxymethyl cytidine modification
分子名称:	RNA (27-MER)
著者	Ennifar, E, Micura, R.
登録日	2016-12-28
公開日	2018-01-17
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (0.851 Å)
主引用文献	Synthesis, Thermodynamic Properties, and Crystal Structure of RNA Oligonucleotides Containing 5-Hydroxymethylcytosine J.Org.Chem., 2017

7QP2

1-deazaguanosine modified-RNA Sarcin Ricin Loop
分子名称:	GLYCEROL, RNA (27-MER)
著者	Ennifar, E, Micura, R, Bereiter, R, Renard, E, Kreutz, C.
登録日	2021-12-30
公開日	2022-07-20
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (0.9 Å)
主引用文献	1-Deazaguanosine-Modified RNA: The Missing Piece for Functional RNA Atomic Mutagenesis. J.Am.Chem.Soc., 144, 2022

4NMG

2'-Trifluoromethylthio-2'-deoxyuridine-modified SRL
分子名称:	23S ribosomal RNA Sarcin Ricin Loop
著者	Ennifar, E, Micura, R, Kosutic, M.
登録日	2013-11-15
公開日	2014-11-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.01 Å)
主引用文献	Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids. J.Am.Chem.Soc., 136, 2014

4NLF

2'-trifluoromethylthio-2'-deoxycytidine-modified SRL
分子名称:	23S ribosomal RNA Sarcin Ricin Loop, SULFATE ION
著者	Ennifar, E, Micura, R, Kosutic, M.
登録日	2013-11-14
公開日	2014-11-19
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1 Å)
主引用文献	Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids. J.Am.Chem.Soc., 136, 2014

4NXH

2'-Trifluoromethylthiouridine-modified E. coli 23S rRNA Sarcin Ricin Loop
分子名称:	23S ribosomal RNA Sarcin Ricin Loop, GLYCEROL, SULFATE ION
著者	Ennifar, E, Micura, R, Kosutic, M.
登録日	2013-12-09
公開日	2014-12-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (1.158 Å)
主引用文献	Surprising base pairing and structural properties of 2'-trifluoromethylthio-modified ribonucleic acids. J.Am.Chem.Soc., 136, 2014

5DGF

Complex of yeast 80S ribosome with hypusine-containing/non-modified eIF5A and/or a peptidyl-tRNA analog
分子名称:	18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ...
著者	Melnikov, S, Mailliot, J, Shin, B.-S, Rigger, L, Yusupova, G, Micura, R, Dever, T.E, Yusupov, M.
登録日	2015-08-27
公開日	2016-12-14
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (3.3 Å)
主引用文献	Coping with proline stalling: structural basis of hypusine-induced protein synthesis by the eukaryotic ribosome To Be Published

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