3O62
 
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1AIO
 | | CRYSTAL STRUCTURE OF A DOUBLE-STRANDED DNA CONTAINING THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN | | 分子名称: | Cisplatin, DNA (5'-D(*CP*CP*(BRU)P*CP*TP*[PT(NH3)2(GP*GP)]*TP*CP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3') | | 著者 | Takahara, P.M, Rosenzweig, A.C, Frederick, C.A, Lippard, S.J. | | 登録日 | 1997-04-23 | | 公開日 | 1997-04-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin.
Nature, 377, 1995
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4GAM
 | | Complex structure of Methane monooxygenase hydroxylase and regulatory subunit | | 分子名称: | FE (III) ION, Methane monooxygenase component A alpha chain, Methane monooxygenase component A beta chain, ... | | 著者 | Lee, S.J, Lippard, S.J, Cho, U.-S. | | 登録日 | 2012-07-25 | | 公開日 | 2013-02-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | | 主引用文献 | Control of substrate access to the active site in methane monooxygenase.
Nature, 494, 2013
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1MTY
 | | METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH) | | 分子名称: | FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE | | 著者 | Rosenzweig, A.C, Nordlund, P, Lippard, S.J, Frederick, C.A. | | 登録日 | 1996-07-10 | | 公開日 | 1997-04-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins, 29, 1997
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1A84
 | | NMR SOLUTION STRUCTURE OF A DNA DODECAMER DUPLEX CONTAINING A CIS-DIAMMINEPLATINUM(II) D(GPG) INTRASTRAND CROSS-LINK, THE MAJOR ADDUCT OF THE ANTICANCER DRUG CISPLATIN, 1 STRUCTURE | | 分子名称: | Cisplatin, DNA D(CCTCTG*G*TCTCC), DNA D(GGAGACCAGAGG) | | 著者 | Gelasco, A, Lippard, S.J. | | 登録日 | 1998-04-02 | | 公開日 | 1998-11-25 | | 最終更新日 | 2024-04-10 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin.
Biochemistry, 37, 1998
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3CO3
 | | X-Ray Crystal Structure of a Monofunctional Platinum-DNA Adduct, cis-{Pt(NH3)2(pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex | | 分子名称: | 5'-D(*DCP*DCP*DTP*DCP*DTP*DCP*DGP*DTP*DCP*DTP*DCP*DC)-3', 5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DGP*DAP*DGP*DAP*DGP*DG)-3', cis-diammine(pyridine)chloroplatinum(II) | | 著者 | Lovejoy, K.S, Todd, R.C, Zhang, S, McCormick, M.S, D'Aquino, J.A, Reardon, J.T, Sancar, A, Giacomini, K.M, Lippard, S.J. | | 登録日 | 2008-03-27 | | 公開日 | 2008-06-10 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3LPV
 | | X-ray crystal structure of duplex DNA containing a cisplatin 1,2-d(GpG) intrastrand cross-link | | 分子名称: | 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', Cisplatin, ... | | 著者 | Todd, R.C, Lippard, S.J. | | 登録日 | 2010-02-06 | | 公開日 | 2010-08-11 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH(3))(2)}(2+)-d(GpG) cross-link at 1.77A resolution.
J.Inorg.Biochem., 104, 2010
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2RDB
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase I100W Mutant | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, FE (III) ION, GLYCEROL, ... | | 著者 | Murray, L.J, Garcia-Serres, R, McCormick, M.S, Davydov, R, Naik, S, Hoffman, B.M, Huynh, B.H, Lippard, S.J. | | 登録日 | 2007-09-21 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase.
Biochemistry, 46, 2007
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3U52
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1LU5
 | | 2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex | | 分子名称: | 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', CIS-(AMMINE)(CYCLOHEXYLAMINE)PLATINUM(II) COMPLEX | | 著者 | Silverman, A.P, Bu, W, Cohen, S.M, Lippard, S.J. | | 登録日 | 2002-05-21 | | 公開日 | 2002-12-20 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2.4-A Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to
a Dodecamer DNA Duplex
J.Biol.Chem., 277, 2002
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2IND
 | | Mn(II) Reconstituted Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure | | 分子名称: | HEXAETHYLENE GLYCOL, MANGANESE (II) ION, Toluene, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J. | | 登録日 | 2006-10-06 | | 公開日 | 2006-12-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
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2INP
 | | Structure of the Phenol Hydroxylase-Regulatory Protein Complex | | 分子名称: | FE (III) ION, Phenol hydroxylase component phL, Phenol hydroxylase component phM, ... | | 著者 | Sazinsky, M.S, Dunten, P.W, McCormick, M.S, Lippard, S.J. | | 登録日 | 2006-10-08 | | 公開日 | 2007-01-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
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2INC
 | | Native Toluene/o-xylene Monooxygenase Hydroxylase X-ray Crystal Structure | | 分子名称: | FE (III) ION, HEXAETHYLENE GLYCOL, Toluene, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Condon, K.L, Lippard, S.J. | | 登録日 | 2006-10-06 | | 公開日 | 2006-11-28 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | X-ray crystal structures of manganese(II)-reconstituted and native toluene/o-xylene monooxygenase hydroxylase reveal rotamer shifts in conserved residues and an enhanced view of the protein interior.
J.Am.Chem.Soc., 128, 2006
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2INN
 | | Structure of the Phenol Hydroxyalse-Regulatory Protein Complex | | 分子名称: | FE (III) ION, MOLYBDATE ION, Phenol hydroxylase component phL, ... | | 著者 | Sazinsky, M.H, Dunten, P.W, McCormick, M.S, Lippard, S.J. | | 登録日 | 2006-10-08 | | 公開日 | 2007-01-16 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase.
Biochemistry, 45, 2006
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1IHH
 | | 2.4 ANGSTROM CRYSTAL STRUCTURE OF AN OXALIPLATIN 1,2-D(GPG) INTRASTRAND CROSS-LINK IN A DNA DODECAMER DUPLEX | | 分子名称: | 1R,2R-DIAMINOCYCLOHEXANE, 5'-D(*CP*CP*TP*CP*TP*GP*GP*TP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*AP*CP*CP*AP*GP*AP*GP*G)-3', ... | | 著者 | Spingler, B, Whittington, D.A, Lippard, S.J. | | 登録日 | 2001-04-19 | | 公開日 | 2001-10-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | 2.4 A crystal structure of an oxaliplatin 1,2-d(GpG) intrastrand cross-link in a DNA dodecamer duplex.
Inorg.Chem., 40, 2001
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1JQ4
 | | [2Fe-2S] Domain of Methane Monooxygenase Reductase from Methylococcus capsulatus (Bath) | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, METHANE MONOOXYGENASE COMPONENT C | | 著者 | Mueller, J, Lugovskoy, A.A, Wagner, G, Lippard, S.J. | | 登録日 | 2001-08-03 | | 公開日 | 2002-01-09 | | 最終更新日 | 2022-02-23 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR structure of the [2Fe-2S] ferredoxin domain from soluble methane monooxygenase reductase and interaction with its hydroxylase.
Biochemistry, 41, 2002
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3M4O
 | | RNA polymerase II elongation complex B | | 分子名称: | DNA (28-MER), DNA (5'-D(P*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Wang, D, Zhu, G, Huang, X, Lippard, S.J. | | 登録日 | 2010-03-11 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.57 Å) | | 主引用文献 | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3M3Y
 | | RNA polymerase II elongation complex C | | 分子名称: | DNA (28-MER), DNA (5'-D(*GP*TP*GP*GP*TP*TP*AP*TP*GP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | | 著者 | Wang, D, Zhu, G, Huang, X, Lippard, S.J. | | 登録日 | 2010-03-10 | | 公開日 | 2010-05-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.18 Å) | | 主引用文献 | X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3N1Y
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201G Mutant | | 分子名称: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | 登録日 | 2010-05-17 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N1Z
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201S Mutant | | 分子名称: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | 登録日 | 2010-05-17 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N20
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201V Mutant | | 分子名称: | FE (III) ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | McCormick, M.S, Sazinsky, M.H, Lippard, S.J. | | 登録日 | 2010-05-17 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3N1X
 | | X-ray Crystal Structure of Toluene/o-Xylene Monooxygenase Hydroxylase T201C Mutant | | 分子名称: | 1,2-ETHANEDIOL, FE (III) ION, HYDROXIDE ION, ... | | 著者 | Sazinsky, M.H, McCormick, M.S, Lippard, S.J. | | 登録日 | 2010-05-17 | | 公開日 | 2010-10-13 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase.
J.Am.Chem.Soc., 132, 2010
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3RNB
 | | Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/F176W Double Mutant | | 分子名称: | FE (III) ION, HYDROXIDE ION, SULFATE ION, ... | | 著者 | Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H. | | 登録日 | 2011-04-22 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RNG
 | | Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/W167E Double Mutant | | 分子名称: | FE (III) ION, HYDROXIDE ION, Toluene o-xylene monooxygenase component | | 著者 | Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H. | | 登録日 | 2011-04-22 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3RNA
 | | Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase T201S/I100W Double Mutant | | 分子名称: | FE (III) ION, HYDROXIDE ION, Toluene o-xylene monooxygenase component | | 著者 | Gucinski, G, Song, W.J, Lippard, S.J, Sazinsky, M.H. | | 登録日 | 2011-04-22 | | 公開日 | 2011-08-17 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme.
Proc.Natl.Acad.Sci.USA, 108, 2011
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