4B7O
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4PA1
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1MKB
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1MKA
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4MQ3
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6EX9
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5OVN
| Crystal Structure of FIV Reverse Transcriptase | Descriptor: | POL protein | Authors: | Galilee, M, Alian, A. | Deposit date: | 2017-08-29 | Release date: | 2018-01-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.942 Å) | Cite: | The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance. PLoS Pathog., 14, 2018
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6VVH
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7JGV
| CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH COMPOUND 1620116, CRYSTAL FORM 2 | Descriptor: | 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 | Authors: | Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. | Deposit date: | 2020-07-19 | Release date: | 2021-02-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
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7JGW
| Crystal structure of BCL-XL in complex with COMPOUND 1620116, CRYSTAL FORM 1 | Descriptor: | 6-[(8E)-8-{2-[4-(benzylcarbamoyl)-1,3-thiazol-2-yl]hydrazinylidene}-5,6,7,8-tetrahydronaphthalen-2-yl]-3-(2-phenylethoxy)pyridine-2-carboxylic acid, Bcl-2-like protein 1 | Authors: | Lee, M, Fairlie, W.D, Smith, B.J, Lee, E.F. | Deposit date: | 2020-07-19 | Release date: | 2021-02-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2. Acs Infect Dis., 7, 2021
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6XFM
| Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS | Descriptor: | RNA-binding protein FUS | Authors: | Tycko, R, Lee, M, Ghosh, U, Thurber, K, Kato, M. | Deposit date: | 2020-06-15 | Release date: | 2020-10-07 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Molecular structure and interactions within amyloid-like fibrils formed by a low-complexity protein sequence from FUS. Nat Commun, 11, 2020
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7SP0
| Crystal structure of human SFPQ L534I mutant in complex with zinc | Descriptor: | Splicing factor, proline- and glutamine-rich, ZINC ION | Authors: | Lee, M. | Deposit date: | 2021-11-01 | Release date: | 2022-10-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Familial ALS-associated SFPQ variants promote the formation of SFPQ cytoplasmic aggregates in primary neurons. Open Biology, 12, 2022
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6OWJ
| Zn-mediated polymerization of human SFPQ | Descriptor: | Splicing factor, proline- and glutamine-rich, ZINC ION | Authors: | Lee, M. | Deposit date: | 2019-05-10 | Release date: | 2020-02-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural basis of the zinc-induced cytoplasmic aggregation of the RNA-binding protein SFPQ. Nucleic Acids Res., 48, 2020
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8EZE
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6VVI
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8EZD
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5K3X
| Crystal Structure of the sulfite dehydrogenase, SorT R78K mutant from Sinorhizobium meliloti | Descriptor: | (MOLYBDOPTERIN-S,S)-OXO-MOLYBDENUM, GLYCEROL, Putative sulfite oxidase | Authors: | Lee, M, McGrath, A, Maher, M. | Deposit date: | 2016-05-20 | Release date: | 2017-05-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The central active site arginine in sulfite oxidizing enzymes alters kinetic properties by controlling electron transfer and redox interactions. Biochim. Biophys. Acta, 1859, 2017
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4OCA
| Cryatal structure of ArnB K188A complexted with PLP and UDP-Ara4N | Descriptor: | (2R,3R,4S,5S)-3,4-dihydroxy-5-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]tetrahydro-2H-pyr an-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase | Authors: | Sousa, M.C, Lee, M. | Deposit date: | 2014-01-08 | Release date: | 2014-03-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for Substrate Specificity in ArnB. A Key Enzyme in the Polymyxin Resistance Pathway of Gram-Negative Bacteria. Biochemistry, 53, 2014
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5WPA
| Structure of human SFPQ/PSPC1 heterodimer | Descriptor: | Paraspeckle component 1, Splicing factor, proline- and glutamine-rich | Authors: | Lee, M. | Deposit date: | 2017-08-04 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structure of a SFPQ/PSPC1 heterodimer provides insights into preferential heterodimerization of human DBHS family proteins. J. Biol. Chem., 293, 2018
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6NCQ
| The dimerization domain of human SFPQ in space group C2221 | Descriptor: | Splicing factor, proline- and glutamine-rich | Authors: | Lee, M. | Deposit date: | 2018-12-12 | Release date: | 2019-06-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A new crystal structure and small-angle X-ray scattering analysis of the homodimer of human SFPQ. Acta Crystallogr.,Sect.F, 75, 2019
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6YAR
| Crystal structure of a Selenium-derivatized complex of the bacterial cellulose secretion regulators BcsR and BcsQ, crystallized in the presence of AppCp | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsQ, Bacterial cellulose secretion regulator BcsR, ... | Authors: | Caleechurn, M, Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | Deposit date: | 2020-03-12 | Release date: | 2021-02-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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6YB3
| Crystal structure of a native BcsRQ complex purified and crystallized in the absence of nucleotide | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsQ, Bacterial cellulose secretion regulator BcsR, ... | Authors: | Caleechurn, M, Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | Deposit date: | 2020-03-15 | Release date: | 2021-02-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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6YB5
| Orthorhombic crystal structure of a native BcsRQ complex crystallized in the presence of ADP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsQ, Bacterial cellulose secretion regulator BcsR, ... | Authors: | Caleechurn, M, Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | Deposit date: | 2020-03-15 | Release date: | 2021-02-24 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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5AER
| Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with D2 dopamine receptor peptide from Homo sapiens | Descriptor: | CALCIUM ION, D(2) DOPAMINE RECEPTOR, NEURONAL CALCIUM SENSOR 1, ... | Authors: | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | Deposit date: | 2015-01-08 | Release date: | 2015-02-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein-Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. J.Biol.Chem., 290, 2015
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5AFP
| Neuronal calcium sensor-1 (NCS-1)from Rattus norvegicus complex with rhodopsin kinase peptide from Homo sapiens | Descriptor: | CALCIUM ION, NEURONAL CALCIUM SENSOR 1, RHODOPSIN KINASE, ... | Authors: | Saleem, M, Karuppiah, V, Pandalaneni, S, Burgoyne, R, Derrick, J.P, Lian, L.Y. | Deposit date: | 2015-01-23 | Release date: | 2015-03-18 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Neuronal Calcium Sensor-1 Binds the D2 Dopamine Receptor and G-Protein Coupled Receptor Kinase 1 (Grk1) Peptides Using Different Modes of Interactions. J.Biol.Chem., 290, 2015
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