2BNH
 
 | | PORCINE RIBONUCLEASE INHIBITOR | | Descriptor: | RIBONUCLEASE INHIBITOR | | Authors: | Kobe, B, Deisenhofer, J. | | Deposit date: | 1996-06-29 | | Release date: | 1997-03-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A.
J.Mol.Biol., 264, 1996
|
|
1DFJ
 | |
1IAL
 | | IMPORTIN ALPHA, MOUSE | | Descriptor: | IMPORTIN ALPHA | | Authors: | Kobe, B. | | Deposit date: | 1999-01-12 | | Release date: | 1999-06-15 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha.
Nat.Struct.Biol., 6, 1999
|
|
1KOB
 | | TWITCHIN KINASE FRAGMENT (APLYSIA), AUTOREGULATED PROTEIN KINASE DOMAIN | | Descriptor: | TWITCHIN, VALINE | | Authors: | Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E. | | Deposit date: | 1996-06-28 | | Release date: | 1997-03-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
|
|
2PHM
 | | STRUCTURE OF PHENYLALANINE HYDROXYLASE DEPHOSPHORYLATED | | Descriptor: | FE (III) ION, PROTEIN (PHENYLALANINE-4-HYDROXYLASE) | | Authors: | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | | Deposit date: | 1998-11-11 | | Release date: | 1999-04-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
|
|
1PHZ
 | | STRUCTURE OF PHOSPHORYLATED PHENYLALANINE HYDROXYLASE | | Descriptor: | FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE) | | Authors: | Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. | | Deposit date: | 1998-11-11 | | Release date: | 1999-04-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of autoregulation of phenylalanine hydroxylase.
Nat.Struct.Biol., 6, 1999
|
|
1KOA
 | | TWITCHIN KINASE FRAGMENT (C.ELEGANS), AUTOREGULATED PROTEIN KINASE AND IMMUNOGLOBULIN DOMAINS | | Descriptor: | TWITCHIN | | Authors: | Kobe, B, Heierhorst, J, Feil, S.C, Parker, M.W, Benian, G.M, Weiss, K.R, Kemp, B.E. | | Deposit date: | 1996-06-28 | | Release date: | 1997-03-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J., 15, 1996
|
|
1MG1
 | | HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA | | Descriptor: | CHLORIDE ION, PROTEIN (HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Kobe, B, Center, R.J, Kemp, B.E, Poumbourios, P. | | Deposit date: | 1999-03-01 | | Release date: | 1999-04-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins.
Proc.Natl.Acad.Sci.USA, 96, 1999
|
|
8JZM
 | | The inhibitor of Toll-like receptor signaling o-vanillin binds covalently to MAL/TIRAP Lys-210 | | Descriptor: | Toll/interleukin-1 receptor domain-containing adapter protein | | Authors: | Rahaman, M.H, Jia, X, Maxwell, M.J, Mobli, M, Kobe, B. | | Deposit date: | 2023-07-05 | | Release date: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2.
J Enzyme Inhib Med Chem, 39, 2024
|
|
7BEQ
 | | MicroED structure of the MyD88 TIR domain higher-order assembly | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-10 | | Last modified: | 2024-01-31 | | Method: | ELECTRON CRYSTALLOGRAPHY (3 Å) | | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
|
|
7BER
 | | SFX structure of the MyD88 TIR domain higher-order assembly (solved, rebuilt and refined using an identical protocol to the MicroED structure of the MyD88 TIR domain higher-order assembly) | | Descriptor: | Myeloid differentiation primary response protein MyD88 | | Authors: | Clabbers, M.T.B, Holmes, S, Muusse, T.W, Vajjhala, P, Thygesen, S.J, Malde, A.K, Hunter, D.J.B, Croll, T.I, Nanson, J.D, Rahaman, M.H, Aquila, A, Hunter, M.S, Liang, M, Yoon, C.H, Zhao, J, Zatsepin, N.A, Abbey, B, Sierecki, E, Gambin, Y, Darmanin, C, Kobe, B, Xu, H, Ve, T. | | Deposit date: | 2020-12-24 | | Release date: | 2021-03-10 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography.
Nat Commun, 12, 2021
|
|
6C80
 | | Crystal structure of a flax cytokinin oxidase | | Descriptor: | 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Wan, L, Williams, S, Kobe, B. | | Deposit date: | 2018-01-23 | | Release date: | 2018-06-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A.
Mol. Plant Pathol., 20, 2019
|
|
4OIH
 | | Importin Alpha in Complex with the Bipartite NLS of Prp20 | | Descriptor: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha-1 | | Authors: | Roman, N, Christie, M, Swarbrick, C.M.D, Kobe, B, Forwood, J.K. | | Deposit date: | 2014-01-19 | | Release date: | 2014-02-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
Plos One, 8, 2013
|
|
3EA5
 | | Kap95p Binding Induces the Switch Loops of RanGDP to adopt the GTP-bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, Importin subunit beta-1, ... | | Authors: | Forwood, J.K, Lonhienne, J.K, Guncar, G, Stewart, M, Marfori, M, Kobe, B. | | Deposit date: | 2008-08-24 | | Release date: | 2008-10-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Kap95p binding induces the switch loops of RanGDP to adopt the GTP-bound conformation: implications for nuclear import complex assembly dynamics.
J.Mol.Biol., 383, 2008
|
|
1PJN
 | | Mouse Importin alpha-bipartite NLS N1N2 from Xenopus laevis phosphoprotein Complex | | Descriptor: | Histone-binding protein N1/N2, Importin alpha-2 subunit | | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | | Deposit date: | 2003-06-03 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
|
|
1PJM
 | | Mouse Importin alpha-bipartite NLS from human retinoblastoma protein Complex | | Descriptor: | Importin alpha-2 subunit, Retinoblastoma-associated protein | | Authors: | Fontes, M.R.M, Teh, T, Jans, D, Brinkworth, R.I, Kobe, B. | | Deposit date: | 2003-06-03 | | Release date: | 2003-08-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha
J.Biol.Chem., 278, 2003
|
|
6WES
 | | Crystal structure of the effector SnTox3 from Parastagonospora nodorum | | Descriptor: | Tox3 | | Authors: | Outram, M.A, Williams, S.J, Ericsson, D.J, Kobe, B, Solomon, P.S. | | Deposit date: | 2020-04-02 | | Release date: | 2020-11-04 | | Last modified: | 2021-09-01 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | The crystal structure of SnTox3 from the necrotrophic fungus Parastagonospora nodorum reveals a unique effector fold and provides insight into Snn3 recognition and pro-domain protease processing of fungal effectors.
New Phytol., 231, 2021
|
|
2Y92
 | | Crystal structure of MAL adaptor protein | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN, | | Authors: | Valkov, E, Stamp, A, Martin, J.L, Kobe, B. | | Deposit date: | 2011-02-11 | | Release date: | 2011-09-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection.
Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
1IQ1
 | | CRYSTAL STRUCTURE OF THE IMPORTIN-ALPHA(44-54)-IMPORTIN-ALPHA(70-529) COMPLEX | | Descriptor: | IMPORTIN ALPHA-2 SUBUNIT | | Authors: | Catimel, B, Teh, T, Fontes, M.R.M, Jennings, I.G, Kobe, B. | | Deposit date: | 2001-05-28 | | Release date: | 2001-11-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Biophysical characterization of interactions involving importin-alpha during nuclear import.
J.Biol.Chem., 276, 2001
|
|
8STB
 | | The structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX | | Descriptor: | CHLORIDE ION, GLYCEROL, Glyoxalase, ... | | Authors: | Luo, Z, Jia, X, Yan, X, Qu, X, Kobe, B. | | Deposit date: | 2023-05-09 | | Release date: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | The crystal structure of abxF, an enzyme catalyzing the formation of the chiral spiroketal of an anthrabenzoxocinone antibiotic, (-)-ABX.
To Be Published
|
|
5I33
 | | Unligated adenylosuccinate synthetase from Cryptococcus neoformans | | Descriptor: | Adenylosuccinate synthetase | | Authors: | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | | Deposit date: | 2016-02-09 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.
Acs Infect Dis., 2, 2016
|
|
5I34
 | | Adenylosuccinate synthetase from Cryptococcus neoformans complexed with GDP and IMP | | Descriptor: | Adenylosuccinate synthetase, GUANOSINE-5'-DIPHOSPHATE, INOSINIC ACID | | Authors: | Blundell, R.D, Williams, S.J, Ericsson, D, Fraser, J.A, Kobe, B. | | Deposit date: | 2016-02-09 | | Release date: | 2016-08-24 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.
Acs Infect Dis., 2, 2016
|
|
1EJY
 | |
1EJL
 | |
2YNS
 | | rImp_alpha_B54NLS | | Descriptor: | B54NLS, IMPORTIN SUBUNIT ALPHA-1A | | Authors: | Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. | | Deposit date: | 2012-10-18 | | Release date: | 2013-01-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals.
Plant Cell, 24, 2012
|
|
