4RNA
| Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus | 分子名称: | PHOSPHATE ION, ZINC ION, papain-like protease | 著者 | Lei, H, Santarsiero, B.D, Lee, H, Johnson, M.E. | 登録日 | 2014-10-23 | 公開日 | 2015-03-25 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.794 Å) | 主引用文献 | Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV. Acs Chem.Biol., 10, 2015
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4YIW
| DIHYDROOROTASE FROM BACILLUS ANTHRACIS WITH SUBSTRATE BOUND | 分子名称: | Dihydroorotase, N-CARBAMOYL-L-ASPARTATE, ZINC ION | 著者 | Lei, H, Santarsiero, B.D, Rice, A.J, Lee, H, Johnson, M.E. | 登録日 | 2015-03-02 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase). Bioorg.Med.Chem., 24, 2016
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3UIC
| Crystal Structure of FabI, an Enoyl Reductase from F. tularensis, in complex with a Novel and Potent Inhibitor | 分子名称: | 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Mehboob, S, Santarsiero, B.D, Truong, K, Johnson, M.E. | 登録日 | 2011-11-04 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J.Med.Chem., 55, 2012
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3V4S
| Crystal Structure of ADP-ATP complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CARBONATE ION, ... | 著者 | Fung, L.W, Tuntland, M.L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2011-12-15 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis. Acta Crystallogr.,Sect.D, 70, 2014
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4NYE
| Structures of SAICAR Synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg2+, AIR and L-Asp | 分子名称: | ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | 著者 | Fung, L.W.-M, Johnson, M.E, Abad-Zapatero, C, Wolf, N.M. | 登録日 | 2013-12-10 | 公開日 | 2014-04-02 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr.,Sect.D, 70, 2014
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4NZ9
| Crystal Structure of FabI from S. aureus in complex with a novel benzimidazole inhibitor | 分子名称: | 1-(4-methoxy-3-methylbenzyl)-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole, Enoyl-[acyl-carrier-protein] reductase [NADPH], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Mehboob, S, Johnson, M.E, Santarsiero, B.D. | 登録日 | 2013-12-11 | 公開日 | 2014-12-31 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | To be published To be Published
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4DLK
| Crystal Structure of ATP-Ca++ complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, PHOSPHATE ION, ... | 著者 | Fung, L.W, Tuntland, M.L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2012-02-06 | 公開日 | 2013-02-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis. Acta Crystallogr.,Sect.D, 70, 2014
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4PT5
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4FE2
| X-Ray Structure of SAICAR Synthetase (PurC) from Streptococcus pneumoniae complexed with AIR, ADP, Asp and Mg2+ | 分子名称: | 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Wolf, N, Abad-Zapatero, C, Johnson, M.E, Fung, L.M.-W. | 登録日 | 2012-05-29 | 公開日 | 2013-05-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.288 Å) | 主引用文献 | Structures of SAICAR synthetase (PurC) from Streptococcus pneumoniae with ADP, Mg(2+), AIR and Asp. Acta Crystallogr.,Sect.D, 70, 2014
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4IQL
| Crystal Structure of Porphyromonas gingivalis Enoyl-ACP Reductase II (FabK) with cofactors NADPH and FMN | 分子名称: | Enoyl-(Acyl-carrier-protein) reductase II, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | 著者 | Hevener, K.E, Santarsiero, B.D, Su, P.-C, Boci, T, Truong, K, Johnson, M.E, Mehboob, S. | 登録日 | 2013-01-11 | 公開日 | 2014-01-29 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.938 Å) | 主引用文献 | Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK). Acta Crystallogr F Struct Biol Commun, 74, 2018
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4J3F
| Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold. | 分子名称: | 1-(4-methoxy-3-methylbenzyl)-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2013-02-05 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Bioorg.Med.Chem.Lett., 25, 2015
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4J1N
| Crystal structures of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold | 分子名称: | 1-(4-methoxy-3-methylbenzyl)-1,5,6,7-tetrahydroindeno[5,6-d]imidazole, Enoyl-[acyl-carrier-protein] reductase [NADH], GLYCEROL, ... | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2013-02-01 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Bioorg.Med.Chem.Lett., 25, 2015
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4J4T
| Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold | 分子名称: | 1-(1,3-benzodioxol-5-ylmethyl)-5,6,7,8-tetrahydro-1H-naphtho[2,3-d]imidazole, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ... | 著者 | Mehboob, S, Boci, T, Brubaker, L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2013-02-07 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI). Bioorg.Med.Chem.Lett., 25, 2015
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3MPG
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3NRC
| Crystal Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD+ and triclosan | 分子名称: | Enoyl-[acyl-carrier-protein] reductase (NADH), NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN | 著者 | Mehboob, S, Santarsiero, B.D, Truong, K, Johnson, M.E. | 登録日 | 2010-06-30 | 公開日 | 2010-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Structure of the Francisella tularensis enoyl-acyl carrier protein reductase (FabI) in complex with NAD(+) and triclosan. Acta Crystallogr.,Sect.F, 66, 2010
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3Q2O
| Crystal Structure of purK: N5-carboxyaminoimidazole ribonucleotide synthetase | 分子名称: | MAGNESIUM ION, Phosphoribosylaminoimidazole carboxylase, ATPase subunit | 著者 | Fung, L.W, Tuntland, M.L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2010-12-20 | 公開日 | 2011-10-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structure of N(5)-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis. Acta Crystallogr.,Sect.D, 67, 2011
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3QFF
| Crystal Structure of ADP complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, N5-carboxyaminoimidazole ribonucleotide synthetase | 著者 | Fung, L.W, Tuntland, M.L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2011-01-21 | 公開日 | 2011-12-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis. Acta Crystallogr.,Sect.D, 70, 2014
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3R5H
| Crystal Structure of ADP-AIR complex of purK: N5-carboxyaminoimidazole ribonucleotide synthetase | 分子名称: | 5-AMINOIMIDAZOLE RIBONUCLEOTIDE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Fung, L.W, Tuntland, M.L, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2011-03-18 | 公開日 | 2012-03-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Elucidation of the bicarbonate binding site and insights into the carboxylation mechanism of (N(5))-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis Acta Crystallogr.,Sect.D, 70, 2014
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5T1V
| Crystal structure of Zika virus NS2B-NS3 protease in apo-form. | 分子名称: | NS2B-NS3 protease,NS2B-NS3 protease | 著者 | Nocadello, S, Light, S.H, Minasov, G, Shuvalova, L, Cardona-Correa, A.A, Ojeda, I, Vargas, J, Johnson, M.E, Lee, H, Anderson, W.F, Center for Structural Genomics of Infectious Diseases, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-08-22 | 公開日 | 2016-09-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Crystal structure of Zika virus NS2B-NS3 protease in apo-form. To Be Published
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5TXG
| Crystal structure of the Zika virus NS3 helicase. | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NS3 helicase, POTASSIUM ION | 著者 | Nocadello, S, Light, S.H, Minasov, G, Shuvalova, L, Cardona-Correa, A.A, Ojeda, I, Vargas, J, Johnson, M.E, Lee, H, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2016-11-16 | 公開日 | 2016-12-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal structure of the Zika virus NS3 helicase. To be published
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1OWA
| Solution Structural Studies on Human Erythrocyte Alpha Spectrin N Terminal Tetramerization Domain | 分子名称: | Spectrin alpha chain, erythrocyte | 著者 | Park, S, Caffrey, M.S, Johnson, M.E, Fung, L.W. | 登録日 | 2003-03-28 | 公開日 | 2004-03-30 | 最終更新日 | 2022-02-23 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structural studies on human erythrocyte alpha-spectrin tetramerization site. J.Biol.Chem., 278, 2003
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2ALV
| X-ray structural analysis of SARS coronavirus 3CL proteinase in complex with designed anti-viral inhibitors | 分子名称: | N-((3S,6R)-6-((S,E)-4-ETHOXYCARBONYL-1-((S)-2-OXOPYRROLIDIN-3-YL)BUT-3-EN-2-YLCARBAMOYL)-2,9-DIMETHYL-4-OXODEC-8-EN-3-YL)-5-METHYLISOXAZOLE-3-CARBOXAMIDE, Replicase polyprotein 1ab | 著者 | Ghosh, A.K, Xi, K, Ratia, K, Santarsiero, B.D, Fu, W, Harcourt, B.H, Rota, P.A, Baker, S.C, Johnson, M.E, Mesecar, A.D. | 登録日 | 2005-08-08 | 公開日 | 2006-08-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. J.Med.Chem., 48, 2005
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2DWU
| Crystal Structure of Glutamate Racemase Isoform RacE1 from Bacillus anthracis | 分子名称: | D-GLUTAMIC ACID, GLYCEROL, Glutamate racemase, ... | 著者 | Mehboob, S, Santarsiero, B.D, Johnson, M.E. | 登録日 | 2006-08-17 | 公開日 | 2007-06-19 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural and Functional Analysis of Two Glutamate Racemase Isozymes from Bacillus anthracis and Implications for Inhibitor Design J.Mol.Biol., 371, 2007
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1TX7
| Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA) | 分子名称: | (4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC ACID, CALCIUM ION, Trypsinogen | 著者 | Cui, J, Marankan, F, Fu, W, Crich, D, Mesecar, A, Johnson, M.E. | 登録日 | 2004-07-02 | 公開日 | 2005-09-20 | 最終更新日 | 2018-04-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | An oxyanion-hole selective serine protease inhibitor in complex with trypsin. Bioorg.Med.Chem., 10, 2002
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2GZM
| Crystal Structure of the Glutamate Racemase from Bacillus anthracis | 分子名称: | D-GLUTAMIC ACID, Glutamate racemase | 著者 | May, M, Santarsiero, B.D, Johnson, M.E, Mesecar, A.D. | 登録日 | 2006-05-11 | 公開日 | 2007-05-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design. J.Mol.Biol., 371, 2007
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