3UIC

Crystal Structure of FabI, an Enoyl Reductase from F. tularensis, in complex with a Novel and Potent Inhibitor

Summary for 3UIC

Entry DOI	10.2210/pdb3uic/pdb
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 1-(3,4-dichlorobenzyl)-5,6-dimethyl-1H-benzimidazole, ... (4 entities in total)
Functional Keywords	rossmann fold, enoyl reductase, nadh binding, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Francisella tularensis subsp. tularensis
Total number of polymer chains	16
Total formula weight	495603.01
Authors	Mehboob, S.,Santarsiero, B.D.,Truong, K.,Johnson, M.E. (deposition date: 2011-11-04, release date: 2012-06-06, Last modification date: 2023-09-13)
Primary citation	Mehboob, S.,Hevener, K.E.,Truong, K.,Boci, T.,Santarsiero, B.D.,Johnson, M.E. Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors. J.Med.Chem., 55:5933-5941, 2012 Cited by PubMed: 22642319 DOI: 10.1021/jm300489v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation