4RNA

Crystal structure of PLpro from Middle East Respiratory Syndrome (MERS) coronavirus

Summary for 4RNA

• Entry DOI: 10.2210/pdb4rna/pdb
• Related: 4PT5
• Descriptor: papain-like protease, ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: mers, coronavirus, papain-like protease, plpro, hydrolase
• Biological source: Human betacoronavirus 2c EMC/2012
• Cellular location: Host cytoplasm, host perinuclear region . Host membrane ; Multi-pass membrane protein : K4LC41
• Total number of polymer chains: 1
• Total formula weight: 36496.75

Authors

Lei, H.,Santarsiero, B.D.,Lee, H.,Johnson, M.E. (deposition date: 2014-10-23, release date: 2015-03-25, Last modification date: 2023-12-06)

• Primary citation: Lee, H.,Lei, H.,Santarsiero, B.D.,Gatuz, J.L.,Cao, S.,Rice, A.J.,Patel, K.,Szypulinski, M.Z.,Ojeda, I.,Ghosh, A.K.,Johnson, M.E.; Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV.; Acs Chem.Biol., 10:1456-1465, 2015; PubMed: 25746232; DOI: 10.1021/cb500917m

Experimental method

X-RAY DIFFRACTION (1.794 Å)