7K4W
| Crystal structure of Kemp Eliminase HG3.17 in the inactive state | 分子名称: | CALCIUM ION, Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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4A2S
| Structure of the engineered retro-aldolase RA95.5 | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE | 著者 | Giger, L, Caner, S, Kast, P, Baker, D, Ban, N, Hilvert, D. | 登録日 | 2011-09-28 | 公開日 | 2012-11-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Evolution of a designed retro-aldolase leads to complete active site remodeling. Nat.Chem.Biol., 9, 2013
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7K4R
| Crystal structure of Kemp Eliminase HG3 K50Q | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4T
| Crystal structure of Kemp Eliminase HG3.17 | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.999 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4P
| Crystal structure of Kemp Eliminase HG3 | 分子名称: | Endo-1,4-beta-xylanase | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7K4S
| Crystal structure of Kemp Eliminase HG3.7 | 分子名称: | Endo-1,4-beta-xylanase, SULFATE ION | 著者 | Padua, R.A.P, Otten, R, Bunzel, A, Nguyen, V, Pitsawong, W, Patterson, M, Sui, S, Perry, S.L, Cohen, A.E, Hilvert, D, Kern, D. | 登録日 | 2020-09-16 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | How directed evolution reshapes the energy landscape in an enzyme to boost catalysis. Science, 370, 2020
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7BWW
| Structure of the engineered metallo-Diels-Alderase DA7 W16S | 分子名称: | ACETIC ACID, BENZOIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Basler, S, Mori, T, Hilvert, D. | 登録日 | 2020-04-16 | 公開日 | 2021-04-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold. Nat.Chem., 13, 2021
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3FWG
| Ferric camphor bound Cytochrome P450cam, Arg365Leu, Glu366Gln, monoclinic crystal form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Camphor 5-monooxygenase, ... | 著者 | Schlichting, I, Von Koenig, K, Aldag, C, Hilvert, D. | 登録日 | 2009-01-18 | 公開日 | 2009-03-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc.Natl.Acad.Sci.USA, 106, 2009
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3FWF
| Ferric camphor bound cytochrome P450cam containing a Selenocysteine as the 5th heme ligand, monoclinic crystal form | 分子名称: | CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Schlichting, I, Von Koenig, K, Aldag, C, Hilvert, D. | 登録日 | 2009-01-18 | 公開日 | 2009-03-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc.Natl.Acad.Sci.USA, 106, 2009
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3FWJ
| Ferric camphor bound Cytochrome P450cam containing a selenocysteine as the 5th heme ligand, orthorombic crystal form | 分子名称: | CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Schlichting, I, von Koenig, K, Aldag, C, Hilvert, D. | 登録日 | 2009-01-18 | 公開日 | 2009-03-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc.Natl.Acad.Sci.USA, 106, 2009
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3FWI
| Ferric camphor bound Cytochrome P450cam containing a selenocysteine as the 5th heme ligand, tetragonal crystal form | 分子名称: | CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ... | 著者 | Schlichting, I, von Koenig, K, Aldag, C, Hilvert, D. | 登録日 | 2009-01-18 | 公開日 | 2009-03-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc.Natl.Acad.Sci.USA, 106, 2009
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5OD1
| Structure of the engineered metalloesterase MID1sc10 complexed with a phosphonate transition state analogue | 分子名称: | GLYCEROL, MID1sc10, ZINC ION, ... | 著者 | Mittl, P.R.E, Studer, S, Hansen, D.A, Hilvert, D. | 登録日 | 2017-07-04 | 公開日 | 2018-12-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science, 362, 2018
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5OD9
| Structure of the engineered metalloesterase MID1sc9 | 分子名称: | (2~{S})-2-phenylpropanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Studer, S, Mittl, P.R.E, Hilvert, D. | 登録日 | 2017-07-05 | 公開日 | 2018-12-12 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | 主引用文献 | Evolution of a highly active and enantiospecific metalloenzyme from short peptides. Science, 362, 2018
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3B5L
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6WVS
| Hyperstable de novo TIM barrel variant DeNovoTIM15 | 分子名称: | DeNovoTIM15 hyperstable de novo TIM barrel | 著者 | Bick, M.J, Haydon, I.C, Caldwell, S.J, Zeymer, C, Huang, P, Fernandez-Velasco, D.A, Baker, D. | 登録日 | 2020-05-06 | 公開日 | 2020-11-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion. Proc.Natl.Acad.Sci.USA, 117, 2020
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3CFJ
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1Y18
| Fab fragment of catalytic elimination antibody 34E4 E(H50)D mutant in complex with hapten | 分子名称: | 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID, CHLORIDE ION, Catalytic antibody 34E4 heavy chain, ... | 著者 | Debler, E.W, Ito, S, Heine, A, Wilson, I.A. | 登録日 | 2004-11-17 | 公開日 | 2005-04-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural origins of efficient proton abstraction from carbon by a catalytic antibody Proc.Natl.Acad.Sci.USA, 102, 2005
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1Y0L
| Catalytic elimination antibody 34E4 in complex with hapten | 分子名称: | 2-AMINO-5,6-DIMETHYL-BENZIMIDAZOLE-1-PENTANOIC ACID, CHLORIDE ION, Catalytic Antibody Fab 34E4 Heavy chain, ... | 著者 | Debler, E.W, Ito, S, Heine, A, Wilson, I.A. | 登録日 | 2004-11-15 | 公開日 | 2005-04-05 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural origins of efficient proton abstraction from carbon by a catalytic antibody Proc.Natl.Acad.Sci.USA, 102, 2005
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1C1E
| CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN | 分子名称: | 1,7,8,9,10,10-HEXACHLORO-4-METHYL-4-AZA-TRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE, CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN), CATALYTIC ANTIBODY 1E9 (LIGHT CHAIN), ... | 著者 | Xu, J, Wilson, I.A. | 登録日 | 1999-07-22 | 公開日 | 2000-03-01 | 最終更新日 | 2013-01-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. Science, 286, 1999
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1C5B
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1C5C
| DECARBOXYLASE CATALYTIC ANTIBODY 21D8-HAPTEN COMPLEX | 分子名称: | 2-ACETYLAMINO-NAPTHALENE-1,5-DISULFONIC ACID, CHIMERIC DECARBOXYLASE ANTIBODY 21D8, GLYCEROL | 著者 | Hotta, K, Wilson, I.A. | 登録日 | 1999-11-09 | 公開日 | 2000-10-11 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. J.Mol.Biol., 302, 2000
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3TC7
| Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR62. | 分子名称: | ACETIC ACID, Indole-3-glycerol phosphate synthase, PHOSPHATE ION | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-08-08 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol., 426, 2014
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3TC6
| Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR63. | 分子名称: | DI(HYDROXYETHYL)ETHER, Indole-3-glycerol phosphate synthase, PHOSPHATE ION | 著者 | Vorobiev, S, Su, M, Bjelic, S, Kipnis, Y, Wang, L, Seetharaman, J, Sahdev, S, Xiao, R, Ciccosanti, C, Baker, D, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-08-08 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. J.Mol.Biol., 426, 2014
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7LGM
| Cyanophycin synthetase from A. baylyi DSM587 with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cyanophycin synthase | 著者 | Sharon, I, Haque, A.S, Lahiri, I, Leschziner, A, Schmeing, T.M. | 登録日 | 2021-01-20 | 公開日 | 2021-08-18 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Structures and function of the amino acid polymerase cyanophycin synthetase. Nat.Chem.Biol., 17, 2021
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7LG5
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