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1T5E
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BU of 1t5e by Molmil
The structure of MexA
分子名称: D-Glyceraldehyde, GLYCEROL, Multidrug resistance protein mexA
著者Higgins, M.K, Bokma, E, Koronakis, E, Hughes, C, Koronakis, V.
登録日2004-05-04
公開日2004-05-18
最終更新日2020-07-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structure of the periplasmic component of a bacterial drug efflux pump
Proc.Natl.Acad.Sci.USA, 101, 2004
1TQQ
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BU of 1tqq by Molmil
Structure of TolC in complex with hexamminecobalt
分子名称: COBALT HEXAMMINE(III), Outer membrane protein tolC
著者Higgins, M.K, Eswaran, J, Edwards, P.C, Schertler, G.F, Hughes, C, Koronakis, V.
登録日2004-06-18
公開日2004-07-20
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug effllux protein TolC
J.Mol.Biol., 342, 2004
3BQK
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BU of 3bqk by Molmil
Structure of a chondroitin sulphate binding DBL3X from a var2csa encoded PfEMP1 protein in complex with sulphate
分子名称: Erythrocyte membrane protein 1, GLYCEROL, SULFATE ION
著者Higgins, M.K.
登録日2007-12-20
公開日2008-06-24
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
3BQI
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BU of 3bqi by Molmil
Structure of a chondroitin sulphate binding DBL3X from a var2csa encoded PfEMP1 protein
分子名称: Erythrocyte membrane protein 1, GLYCEROL
著者Higgins, M.K.
登録日2007-12-20
公開日2008-06-24
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
3BQL
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BU of 3bql by Molmil
Structure of a chondroitin sulphate binding DBL3X domain from a var2csa encoded PfEMP1 protein
分子名称: Erythrocyte membrane protein 1, GLYCEROL, SULFATE ION
著者Higgins, M.K.
登録日2007-12-20
公開日2008-06-24
最終更新日2014-03-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of a chondroitin sulfate-binding domain important in placental malaria.
J.Biol.Chem., 283, 2008
4E40
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BU of 4e40 by Molmil
The haptoglobin-hemoglobin receptor of Trypanosoma congolense
分子名称: Putative uncharacterized protein
著者Higgins, M.K, Tkachenko, O, Brown, A, Reed, J, Carrington, M.
登録日2012-03-11
公開日2013-01-16
最終更新日2013-02-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity.
Proc.Natl.Acad.Sci.USA, 110, 2013
4V3E
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BU of 4v3e by Molmil
The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ENDOTHELIAL PROTEIN C RECEPTOR, ...
著者Lau, C.K.Y, Turner, L, Jespersen, J.S, Lowe, E.D, Petersen, B, Wang, C.W, Petersen, J.E.V, Lusingu, J, Theander, T.G, Lavstsen, T, Higgins, M.K.
登録日2014-10-17
公開日2014-12-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural Conservation Despite Huge Sequence Diversity Allows Epcr Binding by the Pfemp1 Family Implicated in Severe Childhood Malaria.
Cell Host Microbe., 17, 2015
4X0J
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BU of 4x0j by Molmil
Trypanosoma brucei haptoglobin-haemoglobin receptor
分子名称: Haptoglobin-hemoglobin receptor
著者Lane-Serff, H, MacGregor, P, Lowe, E.D, Carrington, M, Higgins, M.K.
登録日2014-11-21
公開日2014-12-24
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
8OVB
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BU of 8ovb by Molmil
Human Complement C3b in complex with Trypanosoma brucei ISG65.
分子名称: Complement C3, Complement C3f fragment, ISG65 G
著者Cook, A.D, Higgins, M.K.
登録日2023-04-25
公開日2024-02-14
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of complement factor C3b inhibition by the trypanosome ISG65 receptor.
To be published
8CDD
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BU of 8cdd by Molmil
PfRH5-PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
分子名称: Cy.003 heavy chain, Cy.003 light chain, Cysteine-rich protective antigen, ...
著者Farrell, B, Higgins, M.K.
登録日2023-01-30
公開日2023-10-25
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The PfRCR complex bridges malaria parasite and erythrocyte during invasion.
Nature, 625, 2024
8CDE
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BU of 8cde by Molmil
PfCyRPA-PfRIPR complex from Plasmodium falciparum bound to antibody Cy.003
分子名称: Cy.003, Cy.003 light chain, Cysteine-rich protective antigen, ...
著者Farrell, B, Higgins, M.K.
登録日2023-01-30
公開日2023-10-25
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The PfRCR complex bridges malaria parasite and erythrocyte during invasion.
Nature, 625, 2024
7ZXF
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BU of 7zxf by Molmil
Pfs48/45 bound to monoclonal antibodies 10D8 and 85RF45.1
分子名称: 10D8 heavy chain, 10D8 light chain, 85RF45.1 heavy chain, ...
著者Ko, K.T, Lennartz, F.L, Higgins, M.K.
登録日2022-05-20
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.72 Å)
主引用文献Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
7ZWF
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BU of 7zwf by Molmil
Pfs48/45 bound to scFv fragment of monoclonal antibody 32F3
分子名称: 32F3scFv, Gametocyte surface protein P45/48, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Ko, K.T, Lennartz, F.L, Higgins, M.K.
登録日2022-05-19
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.132 Å)
主引用文献Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
7ZXG
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BU of 7zxg by Molmil
Pfs48/45 bound to Fab fragment of monoclonal antibody 10D8
分子名称: 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ko, K.T, Lennartz, F.L, Higgins, M.K.
登録日2022-05-20
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
7ZWM
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BU of 7zwm by Molmil
Pfs48/45 central and C-terminal domains bound to Fab fragments of monoclonal antibody 10D8 and 32F3
分子名称: 10D8 heavy chain, 10D8 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ko, K.T, Lennartz, F.L, Higgins, M.K.
登録日2022-05-19
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.69 Å)
主引用文献Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
7ZWI
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BU of 7zwi by Molmil
Pfs48/45 C-terminal domain bound to fab fragment of monoclonal antibody 32F3
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 32F3 heavy chain, 32F3 light chain, ...
著者Ko, K.T, Lennartz, F.L, Higgins, M.K.
登録日2022-05-19
公開日2022-06-22
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies.
Nat Commun, 13, 2022
8A44
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BU of 8a44 by Molmil
Plasmodium vivax Duffy binding protein region II bound the DARC ectodomain and monoclonal antibody DB1
分子名称: Atypical chemokine receptor 1, Duffy binding protein, Heavy chain of monoclonal antibody DB1, ...
著者Moskovitz, R, Higgins, M.K.
登録日2022-06-10
公開日2023-06-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural basis for DARC binding in reticulocyte invasion by Plasmodium vivax.
Nat Commun, 14, 2023
5NST
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BU of 5nst by Molmil
Human monoclonal antibody with a LAIR1 insertion
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy Chain of antibody MGD21, ...
著者Hsieh, F.-L, Higgins, M.K.
登録日2017-04-26
公開日2017-10-04
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition.
Elife, 6, 2017
6XZ6
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BU of 6xz6 by Molmil
Structure of the trypanosome brucei factor H receptor bound to domain D5 of bovine factor H
分子名称: Complement factor H, GARP domain-containing protein
著者Macleod, O.J.S, Carrington, M, Higgins, M.K.
登録日2020-02-02
公開日2020-03-25
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
Nat Commun, 11, 2020
6Z3T
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BU of 6z3t by Molmil
Structure of canine Sec61 inhibited by mycolactone
分子名称: Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, Protein transport protein Sec61 subunit gamma, ...
著者Gerard, S.F, Higgins, M.K.
登録日2020-05-21
公開日2020-07-22
最終更新日2020-08-19
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Structure of the Inhibited State of the Sec Translocon.
Mol.Cell, 79, 2020
6ZDX
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BU of 6zdx by Molmil
RIFIN variable region bound to LILRB1 ectodomain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leukocyte immunoglobulin-like receptor subfamily B member 1, ...
著者Harrison, T.E, Higgins, M.K.
登録日2020-06-15
公開日2020-07-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
Nature, 587, 2020
6ZYV
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BU of 6zyv by Molmil
Structure of a Plasmodium PIR protein ectodomain
分子名称: CIR protein
著者Harrison, T.E, Higgins, M.K.
登録日2020-08-03
公開日2020-11-25
最終更新日2021-01-20
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structure of the Plasmodium -interspersed repeat proteins of the malaria parasite.
Proc.Natl.Acad.Sci.USA, 117, 2020
7PI6
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BU of 7pi6 by Molmil
Trypanosoma brucei ISG65 bound to human complement C3d
分子名称: 2-(2-METHOXYETHOXY)ETHANOL, 65 kDa invariant surface glycoprotein, Complement C3dg fragment, ...
著者Cook, A.D, Higgins, M.K.
登録日2021-08-19
公開日2022-07-27
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Invariant surface glycoprotein 65 of Trypanosoma brucei is a complement C3 receptor.
Nat Commun, 13, 2022
5HU6
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BU of 5hu6 by Molmil
Structure of the T. brucei haptoglobin-haemoglobin receptor bound to human haptolgobin-haemoglobin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Haptoglobin, Haptoglobin-hemoglobin receptor, ...
著者Lane-Serff, H, Higgins, M.K.
登録日2016-01-27
公開日2016-03-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor.
Elife, 3, 2014
5JDO
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BU of 5jdo by Molmil
T. congolense haptoglobin-haemoglobin receptor in complex with haemoglobin
分子名称: Haptoglobin-haemoglobin receptor, Hemoglobin subunit alpha, Hemoglobin subunit beta, ...
著者Lane-Serff, H, Higgins, M.K.
登録日2016-04-17
公開日2016-04-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.
Elife, 5, 2016

 

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