8IHF
 
 | | Cryo-EM structure of HCA2-Gi complex with MK6892 | | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8IHB
 | | Cryo-EM structure of HCA2-Gi complex with GSK256073 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y. | | 登録日 | 2023-02-22 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
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8J7R
 | | Cryo-EM structure of the J-K-St region of EMCV IRES in complex with eIF4G-HEAT1 and eIF4A (J-K-St/eIF4G focused) | | 分子名称: | Eukaryotic translation initiation factor 4 gamma 1, IRES RNA (J-K-St), MAGNESIUM ION | | 著者 | Suzuki, H, Fujiyoshi, Y, Imai, S, Shimada, I. | | 登録日 | 2023-04-28 | | 公開日 | 2023-08-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Dynamically regulated two-site interaction of viral RNA to capture host translation initiation factor.
Nat Commun, 14, 2023
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5X93
 | | Human endothelin receptor type-B in complex with antagonist K-8794 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, CHOLESTEROL, ... | | 著者 | Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O. | | 登録日 | 2017-03-05 | | 公開日 | 2017-08-16 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
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5XPR
 | | Human endothelin receptor type-B in complex with antagonist bosentan | | 分子名称: | 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide, Endothelin B receptor,Endolysin,Endothelin B receptor, SULFATE ION | | 著者 | Shihoya, W, Nishizawa, T, Yamashita, K, Hirata, K, Okuta, A, Tani, K, Fujiyoshi, Y, Doi, T, Nureki, O. | | 登録日 | 2017-06-04 | | 公開日 | 2017-08-16 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
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5YLV
 | | Crystal structure of the gastric proton pump complexed with SCH28080 | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(2-methyl-8-phenylmethoxy-imidazo[1,2-a]pyridin-3-yl)ethanenitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y. | | 登録日 | 2017-10-19 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.79977775 Å) | | 主引用文献 | Crystal structures of the gastric proton pump
Nature, 556, 2018
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5Y0B
 | | PIG GASTRIC H+,K+ - ATPASE IN COMPLEX with BYK99 | | 分子名称: | Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta | | 著者 | Abe, K, Shimokawa, J, Natio, M, Munson, K, Vagin, O, Sachs, G, Suzuki, H, Tani, K, Fujiyoshi, Y. | | 登録日 | 2017-07-16 | | 公開日 | 2017-08-09 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (6.7 Å) | | 主引用文献 | The cryo-EM structure of gastric H(+),K(+)-ATPase with bound BYK99, a high-affinity member of K(+)-competitive, imidazo[1,2-a]pyridine inhibitors
Sci Rep, 7, 2017
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5YLU
 | | Crystal structure of the gastric proton pump complexed with vonoprazan | | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Abe, K, Irie, K, Nakanishi, H, Fujiyoshi, Y. | | 登録日 | 2017-10-19 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.79988956 Å) | | 主引用文献 | Crystal structures of the gastric proton pump
Nature, 556, 2018
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6ACF
 | | structure of leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM | | 分子名称: | Leucine dehydrogenase | | 著者 | Yamaguchi, H, Kamegawa, A, Nakata, K, Kashiwagi, T, Mizukoshi, T, Fujiyoshi, Y, Tani, K. | | 登録日 | 2018-07-26 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy
J. Struct. Biol., 205, 2019
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6ACH
 | | Structure of NAD+-bound leucine dehydrogenase from Geobacillus stearothermophilus by cryo-EM | | 分子名称: | Leucine dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Yamaguchi, H, Kamegawa, A, Nakata, K, Kashiwagi, T, Mizukoshi, T, Fujiyoshi, Y, Tani, K. | | 登録日 | 2018-07-26 | | 公開日 | 2018-12-26 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into thermostabilization of leucine dehydrogenase from its atomic structure by cryo-electron microscopy
J. Struct. Biol., 205, 2019
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6JXI
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2H8A
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7BSS
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, CDC50A, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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7BSQ
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in E1AlF-ADP state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ATP11C, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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7BSU
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-bound E2BeF state | | 分子名称: | 1-deoxy-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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7BSP
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in E1-AMPPCP state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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7BSV
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdSer-occluded E2-AlF state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, CDC50A, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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7BSW
 | | Cryo-EM structure of a human ATP11C-CDC50A flippase in PtdEtn-occluded E2-AlF state | | 分子名称: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ATP11C, ... | | 著者 | Abe, K, Nishizawa, T, Nakanishi, H. | | 登録日 | 2020-03-31 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Transport Cycle of Plasma Membrane Flippase ATP11C by Cryo-EM.
Cell Rep, 32, 2020
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6JXH
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6JXJ
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6JXK
 | | Rb+-bound E2-MgF state of the gastric proton pump (Wild-type) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, MAGNESIUM ION, ... | | 著者 | Abe, K, Irie, K, Yamamoto, K. | | 登録日 | 2019-04-23 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (4.3 Å) | | 主引用文献 | A single K + -binding site in the crystal structure of the gastric proton pump.
Elife, 8, 2019
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6LKN
 | | Crystal structure of ATP11C-CDC50A in PtdSer-bound E2P state | | 分子名称: | 1-deoxy-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Cell cycle control protein 50A, ... | | 著者 | Abe, K, Irie, K, Nakanishi, H, Hasegawa, K. | | 登録日 | 2019-12-19 | | 公開日 | 2020-06-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Crystal structure of a human plasma membrane phospholipid flippase.
J.Biol.Chem., 295, 2020
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8H9X
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8H9Y
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8HA2
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