5YLU
Crystal structure of the gastric proton pump complexed with vonoprazan
Summary for 5YLU
Entry DOI | 10.2210/pdb5ylu/pdb |
Descriptor | Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, ... (8 entities in total) |
Functional Keywords | gastric, proton pump, h+, k+-atpase, p-type atpase, transporter, membrane protein |
Biological source | Sus scrofa (Pig) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P19156 Cell membrane ; Single-pass type II membrane protein : P18434 |
Total number of polymer chains | 2 |
Total formula weight | 151124.46 |
Authors | Abe, K.,Irie, K.,Nakanishi, H.,Fujiyoshi, Y. (deposition date: 2017-10-19, release date: 2018-04-11, Last modification date: 2023-11-22) |
Primary citation | Abe, K.,Irie, K.,Nakanishi, H.,Suzuki, H.,Fujiyoshi, Y. Crystal structures of the gastric proton pump Nature, 556:214-218, 2018 Cited by PubMed: 29618813DOI: 10.1038/s41586-018-0003-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.79988962319 Å) |
Structure validation
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