5YLU

Crystal structure of the gastric proton pump complexed with vonoprazan

Summary for 5YLU

Entry DOI	10.2210/pdb5ylu/pdb
Descriptor	Potassium-transporting ATPase alpha chain 1, Potassium-transporting ATPase subunit beta, 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine, ... (8 entities in total)
Functional Keywords	gastric, proton pump, h+, k+-atpase, p-type atpase, transporter, membrane protein
Biological source	Sus scrofa (Pig) More
Cellular location	Cell membrane ; Multi-pass membrane protein : P19156 Cell membrane ; Single-pass type II membrane protein : P18434
Total number of polymer chains	2
Total formula weight	151124.46
Authors	Abe, K.,Irie, K.,Nakanishi, H.,Fujiyoshi, Y. (deposition date: 2017-10-19, release date: 2018-04-11, Last modification date: 2023-11-22)
Primary citation	Abe, K.,Irie, K.,Nakanishi, H.,Suzuki, H.,Fujiyoshi, Y. Crystal structures of the gastric proton pump Nature, 556:214-218, 2018 Cited by PubMed: 29618813 DOI: 10.1038/s41586-018-0003-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79988962319 Å)

Structure validation