5YLU
Crystal structure of the gastric proton pump complexed with vonoprazan
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Potassium-transporting ATPase alpha chain 1 | polymer | 1034 | 114391.7 | 1 | UniProt (P19156) Pfam (PF09040) Pfam (PF00690) Pfam (PF00122) Pfam (PF13246) Pfam (PF08282) Pfam (PF00689) | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit alpha,Proton pump |
| 2 | B (B) | Potassium-transporting ATPase subunit beta | polymer | 289 | 32982.7 | 1 | UniProt (P18434) Pfam (PF00287) | Sus scrofa (Pig) | Gastric H(+)/K(+) ATPase subunit beta,Proton pump beta chain,gp60-90 |
| 3 | C (A) | 1-[5-(2-fluorophenyl)-1-pyridin-3-ylsulfonyl-pyrrol-3-yl]-~{N}-methyl-methanamine | non-polymer | 345.4 | 1 | Chemie (HKT) PubChem (15981397) | |||
| 4 | D, E (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 2 | Chemie (PCW) | |||
| 5 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | G, L (A, B) | O-DODECANYL OCTAETHYLENE GLYCOL | non-polymer | 538.8 | 2 | Chemie (CE1) PubChem (123921) | |||
| 7 | H (A) | BERYLLIUM TRIFLUORIDE ION | non-polymer | 66.0 | 1 | Chemie (BEF) | |||
| 8 | I, J, K (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) PubChem (24139) | |||
| 9 | M, N (A, B) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 0 - 1033 (UniProt: P19156)
| PDB | External Database | Details |
|---|---|---|
| Cys 220 | Arg 221 | engineered mutation |
| Cys 593 | Ser 594 | engineered mutation |
| Ser 1005 | Gly 1006 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 147374.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3751.1 | |
| All* | Total formula weight | 151125.5 |
