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MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN
Descriptor:	BETA-2 MICROGLOBULIN, MHC CLASS I H-2KB HEAVY CHAIN, SENDAI VIRUS NUCLEOPROTEIN
Authors:	Fremont, D.H, Wilson, I.A.
Deposit date:	1994-11-01
Release date:	1996-06-20
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science, 257, 1992

2VAA

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
Descriptor:	BETA-2 MICROGLOBULIN, MHC CLASS I H-2KB HEAVY CHAIN, VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN
Authors:	Fremont, D.H, Wilson, I.A.
Deposit date:	1994-11-01
Release date:	1996-06-20
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science, 257, 1992

3M5R

Crystal Structure of Swine Flu Virus NS1 Effector Domain from H1N1 Influenza A/California/07/2009
Descriptor:	Nonstructural protein 1
Authors:	Fremont, D.H, Yu, Y.Y.L, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2010-03-13
Release date:	2010-04-07
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal Structure of Swine Flu Virus NS1 Effector Domain from H1N1 Influenza A/California/07/2009 To be Published

3OQ3

Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor
Descriptor:	1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, ...
Authors:	Fremont, D.H, Lee, C.A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2010-09-02
Release date:	2011-05-18
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor To be Published

1VAC

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND CHICKEN OVALBUMIN
Descriptor:	BETA-2 MICROGLOBULIN, CHICKEN OVALBUMIN, MHC CLASS I H-2KB HEAVY CHAIN
Authors:	Fremont, D.H, Wilson, I.A.
Deposit date:	1994-11-01
Release date:	1996-06-20
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc.Natl.Acad.Sci.USA, 92, 1995

1VAD

MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE
Descriptor:	BETA-2 MICROGLOBULIN, MHC CLASS I H-2KB HEAVY CHAIN, YEAST ALPHA-GLUCOSIDASE
Authors:	Fremont, D.H, Wilson, I.A.
Deposit date:	1994-11-01
Release date:	1996-06-20
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc.Natl.Acad.Sci.USA, 92, 1995

1EYH

CRYSTAL STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN AT 1.56 ANGSTROM RESOLUTION
Descriptor:	EPSIN
Authors:	Fremont, D.H.
Deposit date:	2000-05-06
Release date:	2000-06-07
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.56 Å)
Cite:	CRYSTAL STRUCTURE OF THE EPSIN N-TERMINAL HOMOLOGY (ENTH) DOMAIN AT 1.56 ANGSTROM RESOLUTION To be Published

1IEA

HISTOCOMPATIBILITY ANTIGEN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS II I-EK
Authors:	Fremont, D.H, Hendrickson, W.A, Marrack, P, Kappler, J.
Deposit date:	1996-04-05
Release date:	1997-06-05
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structures of an MHC class II molecule with covalently bound single peptides. Science, 272, 1996

1IEB

HISTOCOMPATIBILITY ANTIGEN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS II I-EK, SULFATE ION
Authors:	Fremont, D.H, Hendrickson, W.A, Marrack, P, Kappler, J.
Deposit date:	1996-04-05
Release date:	1997-06-05
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structures of an MHC class II molecule with covalently bound single peptides. Science, 272, 1996

1K8I

CRYSTAL STRUCTURE OF MOUSE H2-DM
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II H2-M alpha chain, MHC class II H2-M beta 2 chain
Authors:	Fremont, D.H, Crawford, F, Marrack, P, Hendrickson, W, Kappler, J.
Deposit date:	2001-10-24
Release date:	2001-12-05
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (3.1 Å)
Cite:	Crystal structure of mouse H2-M. Immunity, 9, 1998

1IAK

HISTOCOMPATIBILITY ANTIGEN I-AK
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, MHC CLASS II I-AK
Authors:	Fremont, D.H, Unanue, E.R, Hendrickson, W.A.
Deposit date:	1997-11-18
Release date:	1998-04-15
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structure of I-Ak in complex with a dominant epitope of lysozyme. Immunity, 8, 1998

1KT2

CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IEK BOUND TO MOTH CYTOCHROME C PEPTIDE
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion protein consisting of cytochrome C peptide, ...
Authors:	Fremont, D.H, Dai, S, Chiang, H, Crawford, F, Marrack, P, Kappler, J.
Deposit date:	2002-01-15
Release date:	2002-05-01
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structural basis of cytochrome c presentation by IE(k). J.Exp.Med., 195, 2002

1KTD

CRYSTAL STRUCTURE OF CLASS II MHC MOLECULE IEK BOUND TO PIGEON CYTOCHROME C PEPTIDE
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion protein consisting of cytochrome C peptide, glycine rich linker, ...
Authors:	Fremont, D.H, Dai, S, Chiang, H, Crawford, F, Marrack, P, Kappler, J.
Deposit date:	2002-01-15
Release date:	2002-05-01
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structural basis of cytochrome c presentation by IE(k). J.Exp.Med., 195, 2002

6NK3

Crystal structure of murine Mxra8 ectodomain
Descriptor:	Matrix remodeling-associated protein 8
Authors:	Fremont, D.H, Kim, A.S, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2019-01-04
Release date:	2019-05-22
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor. Cell, 177, 2019

6ORT

Crystal Structure of Bos taurus Mxra8 Ectodomain
Descriptor:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Matrix remodeling-associated protein 8
Authors:	Fremont, D.H, Kim, A.S, Nelson, C.A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2019-04-30
Release date:	2020-03-04
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. Cell Host Microbe, 27, 2020

7MKM

SARS-CoV-2 Spike RBD in complex with neutralizing Fab SARS2-38 (local refinement)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, SARS2-38 Fv heavy chain, SARS2-38 Fv light chain, ...
Authors:	Adams, L.J, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2021-04-24
Release date:	2021-05-12
Last modified:	2021-12-01
Method:	ELECTRON MICROSCOPY (3.16 Å)
Cite:	A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope. Immunity, 54, 2021

7MKL

SARS-CoV-2 Spike in complex with neutralizing Fab SARS2-38 (three down conformation)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SARS2-38 Fv heavy chain, ...
Authors:	Adams, L.J, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2021-04-24
Release date:	2021-05-12
Last modified:	2021-12-01
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	A potently neutralizing SARS-CoV-2 antibody inhibits variants of concern by utilizing unique binding residues in a highly conserved epitope. Immunity, 54, 2021

2FWO

MHC Class I H-2Kd heavy chain in complex with beta-2microglobulin and peptide derived from influenza nucleoprotein
Descriptor:	Beta-2-microglobulin, H-2 class I histocompatibility antigen, K-D alpha chain, ...
Authors:	Mitaksov, V, Fremont, D.H.
Deposit date:	2006-02-02
Release date:	2006-02-21
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural Definition of the H-2Kd Peptide-binding Motif. J.Biol.Chem., 281, 2006

2R29

Neutralization of dengue virus by a serotype cross-reactive antibody elucidated by cryoelectron microscopy and x-ray crystallography
Descriptor:	Envelope protein E, Heavy chain of Fab 1A1D-2, Light chain of Fab 1A1D-2
Authors:	Lok, S.M, Kostyuchenko, V.K, Nybakken, G.E, Holdaway, H.A, Battisti, A.J, Sukupolvi-petty, S, Sedlak, D, Fremont, D.H, Chipman, P.R, Roehrig, J.T, Diamond, M.S, Kuhn, R.J, Rossmann, M.G.
Deposit date:	2007-08-24
Release date:	2007-12-25
Last modified:	2018-01-24
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins. Nat.Struct.Mol.Biol., 15, 2008

2QRI

Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.
Descriptor:	H-2 class I histocompatibility antigen K-B alpha chain, Beta-2 microglobulin, ovalbumin-derived peptide
Authors:	Mitaksov, V.E, Fremont, D.H.
Deposit date:	2007-07-28
Release date:	2007-11-06
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural engineering of pMHC reagents for T cell vaccines and diagnostics. Chem.Biol., 14, 2007

5KVG

Zika specific antibody, ZV-67, bound to ZIKA envelope DIII
Descriptor:	CHLORIDE ION, ZIKA Envelope DIII, ZV-67 Antibody Fab Heavy Chain, ...
Authors:	Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2016-07-14
Release date:	2016-08-03
Last modified:	2016-08-24
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Structural Basis of Zika Virus-Specific Antibody Protection. Cell, 166, 2016

5KVF

Zika specific antibody, ZV-64, bound to ZIKA envelope DIII
Descriptor:	GLYCEROL, ZV-64 Antibody Fab Heavy Chain, ZV-64 Antibody Fab Light Chain, ...
Authors:	Zhao, H, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:	2016-07-14
Release date:	2016-08-03
Last modified:	2016-08-24
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Structural Basis of Zika Virus-Specific Antibody Protection. Cell, 166, 2016

8UFB

Eastern equine encephalitis virus (PE-6) VLP in complex with full-length VLDLR (asymmetric unit)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ...
Authors:	Adams, L.J, Fremont, D.H, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2023-10-04
Release date:	2024-01-17
Last modified:	2024-01-31
Method:	ELECTRON MICROSCOPY (3.89 Å)
Cite:	Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Cell, 187, 2024

8UFC

Eastern equine encephalitis virus (PE-6) VLP in complex with VLDLR LA(1-2) (asymmetric unit)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Capsid protein, ...
Authors:	Adams, L.J, Fremont, D.H, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2023-10-04
Release date:	2024-01-17
Last modified:	2024-01-31
Method:	ELECTRON MICROSCOPY (3.09 Å)
Cite:	Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Cell, 187, 2024

8UFA

Eastern equine encephalitis virus (PE-6) VLP (asymmetric unit)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Capsid protein, E1 protein, ...
Authors:	Adams, L.J, Fremont, D.H, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:	2023-10-04
Release date:	2024-01-17
Last modified:	2024-01-31
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus. Cell, 187, 2024

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