1IEA

HISTOCOMPATIBILITY ANTIGEN

Summary for 1IEA

• Entry DOI: 10.2210/pdb1iea/pdb
• Descriptor: MHC CLASS II I-EK, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: histocompatibility antigen
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 97760.93

Authors

Fremont, D.H.,Hendrickson, W.A.,Marrack, P.,Kappler, J. (deposition date: 1996-04-05, release date: 1997-06-05, Last modification date: 2023-08-09)

Primary citation

Fremont, D.H.,Hendrickson, W.A.,Marrack, P.,Kappler, J.
Structures of an MHC class II molecule with covalently bound single peptides.
Science, 272:1001-1004, 1996

PubMed Abstract: The high-resolution x-ray crystal structures of the murine major histocompatibility complex (MHC) class II molecule, I-E(k), occupied by either of two antigenic peptides were determined. They reveal the structural basis for the I-E(k) peptide binding motif and suggest general principles for additional alleles. A buried cluster of acidic amino acids in the binding groove predicted to be conserved among all murine I-E and human DR MHC class II molecules suggests how pH may influence MHC binding or exchange of peptides. These structures also complement mutational studies on the importance of individual peptide residues to T cell receptor recognition.

PubMed: 8638119

Experimental method

X-RAY DIFFRACTION (2.3 Å)