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2H2D
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The Structural Basis for Sirtuin Substrate Affinity
分子名称: Cellular tumor antigen p53 peptide, NAD-dependent deacetylase, ZINC ION
著者Cosgrove, M.S, Wolberger, C.
登録日2006-05-18
公開日2006-09-19
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献On the Structural Basis of Sirtuin Substrate Affinity
Biochemistry, 45, 2006
2H2F
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The Structural basis for Sirtuin Substrate affinity
分子名称: Cellular tumor antigen p53, NAD-dependent deacetylase, ZINC ION
著者Cosgrove, M.S, Wolberger, C.
登録日2006-05-18
公開日2006-12-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2I
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The Structural basis of Sirtuin Substrate Affinity
分子名称: (2S,5R,8R,11S,14S,17S,21R)-5,8,11,14,17-PENTAMETHYL-4,7,10,13,16,19-HEXAOXADOCOSANE-2,21-DIOL, NAD-dependent deacetylase, ZINC ION
著者Cosgrove, M.S, Wolberger, C.
登録日2006-05-18
公開日2006-12-05
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2G
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The Structural Basis of Sirtuin substrate affinity
分子名称: HISTONE H3 PEPTIDE, NAD-dependent deacetylase, ZINC ION
著者Cosgrove, M.S, Wolberger, C.
登録日2006-05-18
公開日2006-11-28
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
2H2H
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The Structural basis of sirtuin substrate specificity
分子名称: Histone H4, NAD-dependent deacetylase, ZINC ION
著者Cosgrove, M.S, Wolberger, C.
登録日2006-05-18
公開日2006-12-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structural basis of sirtuin substrate affinity
Biochemistry, 45, 2006
1E7M
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ACTIVE SITE MUTANT (D177->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
分子名称: CALCIUM ION, GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE
著者Adams, M.J, Cosgrove, M.S, Gover, S.
登録日2000-08-30
公開日2000-12-11
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
1E7Y
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ACTIVE SITE MUTANT (D177->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES COMPLEXED WITH SUBSTRATE AND NADPH
分子名称: 6-O-phosphono-beta-D-glucopyranose, CALCIUM ION, GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, ...
著者Adams, M.J, Cosgrove, M.S, Gover, S.
登録日2000-09-12
公開日2000-12-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
3EG6
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Structure of WDR5 bound to MLL1 peptide
分子名称: MLL-1 peptide, SULFATE ION, WD repeat-containing protein 5
著者Patel, A, Dharmarajan, V, Cosgrove, M.S.
登録日2008-09-10
公開日2008-09-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.
J.Biol.Chem., 283, 2008
5SXM
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WDR5 in complex with MLL Win motif peptidomimetic
分子名称: ACE-ALA-ARG-THR-GLU-VAL-TYR-NH2, WD repeat-containing protein 5
著者Alicea-Velazquez, N.L, Shinsky, S.A, Cosgrove, M.S.
登録日2016-08-09
公開日2016-09-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
J.Biol.Chem., 291, 2016
7KKF
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Crystal Structure of S. cerevisiae Ess1
分子名称: Peptidyl-prolyl cis-trans isomerase ESS1
著者Namitz, K.E.W, Alicea-Velazquez, N.L, Cosgrove, M.S, Hanes, S.D.
登録日2020-10-27
公開日2021-03-31
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure analysis suggests Ess1 isomerizes the carboxy-terminal domain of RNA polymerase II via a bivalent anchoring mechanism.
Commun Biol, 4, 2021
4ES0
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X-ray structure of WDR5-SETd1b Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase SETD1B, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-21
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.817 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERZ
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X-ray structure of WDR5-MLL4 Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-21
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4EWR
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BU of 4ewr by Molmil
X-ray structure of WDR5-SETd1a Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase SETD1A, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-27
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.503 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ESG
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X-ray structure of WDR5-MLL1 Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase MLL, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-23
公開日2012-05-30
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
1MA3
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Structure of a Sir2 enzyme bound to an acetylated p53 peptide
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cellular tumor antigen p53, Transcriptional regulatory protein, ...
著者Avalos, J.L, Celic, I, Muhammad, S, Cosgrove, M.S, Boeke, J.D, Wolberger, C.
登録日2002-07-31
公開日2002-10-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of a Sir2 enzyme bound to an acetylated p53 peptide
Mol.Cell, 10, 2002
4ERY
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BU of 4ery by Molmil
X-ray structure of WDR5-MLL3 Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase MLL3, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-21
公開日2012-05-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
4ERQ
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BU of 4erq by Molmil
X-ray structure of WDR5-MLL2 Win motif peptide binary complex
分子名称: Histone-lysine N-methyltransferase MLL2, WD repeat-containing protein 5
著者Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S.
登録日2012-04-20
公開日2012-05-16
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.906 Å)
主引用文献Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.
J.Biol.Chem., 287, 2012
2DPG
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COMPLEX OF INACTIVE MUTANT (H240->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES WITH NADP+
分子名称: GLUCOSE 6-PHOSPHATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Adams, M.J, Naylor, C.E, Paludin, S, Gover, S.
登録日1998-04-17
公開日1998-07-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献On the mechanism of the reaction catalyzed by glucose 6-phosphate dehydrogenase.
Biochemistry, 37, 1998
1E77
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COMPLEX OF ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES WITH SUBSTRATE
分子名称: 6-O-phosphono-beta-D-glucopyranose, CALCIUM ION, GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE
著者Adams, M.J, Vandeputte-Rutten, L, Gover, S.
登録日2000-08-24
公開日2000-12-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献An Examination of the Role of Asp-177 in the His-Asp Catalytic Dyad of Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: X-Ray Structure and Ph Dependence of Kinetic Parameters of the D177N Mutant Enzyme
Biochemistry, 39, 2000
7UD5
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Complex between MLL1-WRAD and an H2B-ubiquitinated nucleosome
分子名称: 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
著者Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C.
登録日2022-03-18
公開日2022-09-21
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (4.25 Å)
主引用文献Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
1H94
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COMPLEX OF ACTIVE MUTANT (S215->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM L.MESENTEROIDES WITH COENZYME NAD
分子名称: GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Adams, M.J, Naylor, C.E, Gover, S.
登録日2001-02-23
公開日2001-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
8DU4
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Complex between RbBP5-WDR5 and an H2B-ubiquitinated nucleosome
分子名称: 601 DNA (146-MER), Histone H2A, Histone H2B 1.1, ...
著者Niklas, H.A, Rahman, S, Worden, E.J, Wolberger, C.
登録日2022-07-26
公開日2022-09-21
最終更新日2022-10-05
実験手法ELECTRON MICROSCOPY (3.55 Å)
主引用文献Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome.
Proc.Natl.Acad.Sci.USA, 119, 2022
1H9B
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ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
分子名称: GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, SULFATE ION
著者Adams, M.J, Naylor, C.E, Gover, S.
登録日2001-03-06
公開日2001-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
1H93
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ACTIVE MUTANT (S215->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
分子名称: CALCIUM ION, GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, GLYCEROL
著者Adams, M.J, Naylor, C.E, Gover, S.
登録日2001-02-23
公開日2001-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001
1H9A
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COMPLEX OF ACTIVE MUTANT (Q365->C) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM L. MESENTEROIDES WITH COENZYME NADP
分子名称: GLUCOSE 6-PHOSPHATE 1-DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION
著者Adams, M.J, Naylor, C.E, Gover, S.
登録日2001-03-06
公開日2001-05-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Nadp+ and Nad+ Binding to the Dual Coenzyme Specific Enzyme Leuconostoc Mesenteroides Glucose 6-Phosphate Dehydrogenase: Different Interdomain Hinge Angles are Seen in Different Binary and Ternary Complexes
Acta Crystallogr.,Sect.D, 57, 2001

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