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X-ray structure of furin in complex with the inhibitory antibody Nb14
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CMK-inhibitor, ...
Authors:	Dahms, S.O, Than, M.E.
Deposit date:	2016-04-29
Release date:	2016-12-07
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.998 Å)
Cite:	The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers. Sci Rep, 6, 2016

1ADZ

THE SOLUTION STRUCTURE OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR, NMR, 30 STRUCTURES
Descriptor:	TISSUE FACTOR PATHWAY INHIBITOR
Authors:	Burgering, M.J.M, Orbons, L.P.M.
Deposit date:	1997-02-19
Release date:	1998-02-25
Last modified:	2021-11-03
Method:	SOLUTION NMR
Cite:	The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa. J.Mol.Biol., 269, 1997

1FJS

CRYSTAL STRUCTURE OF THE INHIBITOR ZK-807834 (CI-1031) COMPLEXED WITH FACTOR XA
Descriptor:	CALCIUM ION, CHLORIDE ION, COAGULATION FACTOR XA, ...
Authors:	Adler, M, Whitlow, M.
Deposit date:	2000-08-08
Release date:	2000-10-04
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.92 Å)
Cite:	Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa. Biochemistry, 39, 2000

4OMC

X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
Descriptor:	CALCIUM ION, FORMIC ACID, Furin, ...
Authors:	Dahms, S.O, Than, M.E.
Deposit date:	2014-01-27
Release date:	2014-04-09
Last modified:	2014-05-28
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	X-ray Structures of Human Furin in Complex with Competitive Inhibitors. Acs Chem.Biol., 9, 2014

4OMD

X-ray structure of human furin in complex with the competitive inhibitor Phac-RVR-Amba
Descriptor:	CALCIUM ION, FORMIC ACID, Furin, ...
Authors:	Dahms, S.O, Than, M.E.
Deposit date:	2014-01-27
Release date:	2014-04-09
Last modified:	2014-05-28
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	X-ray Structures of Human Furin in Complex with Competitive Inhibitors. Acs Chem.Biol., 9, 2014

1IQG

Human coagulation factor Xa in complex with M55159
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQN

Human coagulation factor Xa in complex with M55192
Descriptor:	4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQH

Human coagulation factor Xa in complex with M55143
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQE

Human coagulation factor Xa in complex with M55590
Descriptor:	4-[(2R)-3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-1-OXO-2-[[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]AMINO]PROPYL]-THIOMORPHOLINE-1,1-DIOXIDE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQM

Human coagulation factor Xa in complex with M54471
Descriptor:	1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQJ

Human coagulation factor Xa in complex with M55124
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQK

Human coagulation factor Xa in complex with M55113
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQI

Human coagulation factor Xa in complex with M55125
Descriptor:	4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL] METHYL]-2-PIPERAZINECARBOXYLIC ACID, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IOE

Human coagulation factor Xa in complex with M55532
Descriptor:	(-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE, CALCIUM ION, COAGULATION FACTOR XA
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-03-08
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa To be Published

1IQF

Human coagulation factor Xa in complex with M55165
Descriptor:	(2R)-4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1IQL

Human coagulation factor Xa in complex with M54476
Descriptor:	4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:	Shiromizu, I, Matsusue, T.
Deposit date:	2001-07-23
Release date:	2003-09-23
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa To be Published

1MTY

METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH)
Descriptor:	FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE
Authors:	Rosenzweig, A.C, Nordlund, P, Lippard, S.J, Frederick, C.A.
Deposit date:	1996-07-10
Release date:	1997-04-21
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions. Proteins, 29, 1997

1PPB

THE REFINED 1.9 ANGSTROMS CRYSTAL STRUCTURE OF HUMAN ALPHA-THROMBIN: INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT
Descriptor:	ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide
Authors:	Bode, W.
Deposit date:	1991-10-24
Release date:	1994-01-31
Last modified:	2013-02-27
Method:	X-RAY DIFFRACTION (1.92 Å)
Cite:	The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment. EMBO J., 8, 1989

1UVT

BOVINE THROMBIN--BM14.1248 COMPLEX
Descriptor:	N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE, THROMBIN
Authors:	Engh, R.A, Huber, R.
Deposit date:	1996-10-16
Release date:	1997-11-19
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. Structure, 4, 1996

1UVS

BOVINE THROMBIN--BM51.1011 COMPLEX
Descriptor:	THROMBIN, [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE
Authors:	Engh, R.A, Huber, R.
Deposit date:	1996-10-16
Release date:	1997-11-19
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. Structure, 4, 1996

1UVU

BOVINE THROMBIN--BM12.1700 COMPLEX
Descriptor:	3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER, THROMBIN
Authors:	Engh, R.A, Huber, R.
Deposit date:	1996-10-16
Release date:	1997-11-19
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design. Structure, 4, 1996

1WU1

Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine
Descriptor:	5-CHLORO-2-({3-ISOBUTYL-4-[(5-PYRIDIN-4-YLPYRIMIDIN-2-YL)CARBONYL]PIPERAZIN-1-YL}SULFONYL)-1H-INDOLE, CALCIUM ION, Coagulation factor X, ...
Authors:	Suzuki, M.
Deposit date:	2004-11-29
Release date:	2005-11-29
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites Bioorg.Med.Chem., 13, 2005

1XKB

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
Descriptor:	(2S)-(3'-AMIDINO-3-BIPHENYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID, BLOOD COAGULATION FACTOR XA, CALCIUM ION
Authors:	Kamata, K, Kim, S.H.
Deposit date:	1998-03-19
Release date:	1999-03-23
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc.Natl.Acad.Sci.USA, 95, 1998

1XKA

FACTOR XA COMPLEXED WITH A SYNTHETIC INHIBITOR FX-2212A,(2S)-(3'-AMIDINO-3-BIPHENYLYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID
Descriptor:	(2S)-(3'-AMIDINO-3-BIPHENYL)-5-(4-PYRIDYLAMINO)PENTANOIC ACID, BLOOD COAGULATION FACTOR XA, CALCIUM ION
Authors:	Kamata, K, Kim, S.H.
Deposit date:	1998-03-19
Release date:	1999-03-23
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural basis for chemical inhibition of human blood coagulation factor Xa. Proc.Natl.Acad.Sci.USA, 95, 1998

1TFX

COMPLEX OF THE SECOND KUNITZ DOMAIN OF TISSUE FACTOR PATHWAY INHIBITOR WITH PORCINE TRYPSIN
Descriptor:	CALCIUM ION, TISSUE FACTOR PATHWAY INHIBITOR, TRYPSIN
Authors:	Stubbs, M.T, Huber, R.
Deposit date:	1997-01-21
Release date:	1998-01-21
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa. J.Mol.Biol., 269, 1997

<1 2 3 4 5 678 >

Total results:	186
Displayed results:	25
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