2MUS
| HADDOCK calculated model of LIN5001 bound to the HET-s amyloid | 分子名称: | 3''',4'-bis(carboxymethyl)-2,2':5',2'':5'',2''':5''',2''''-quinquethiophene-5,5''''-dicarboxylic acid, Heterokaryon incompatibility protein s | 著者 | Hermann, U.S, Schuetz, A.K, Shirani, H, Saban, D, Nuvolone, M, Huang, D.H, Li, B, Ballmer, B, Aslund, A.K.O, Mason, J.J, Rushing, E, Budka, H, Hammarstrom, P, Bockmann, A, Caflisch, A, Meier, B.H, Nilsson, P.K.R, Hornemann, S, Aguzzi, A. | 登録日 | 2014-09-16 | 公開日 | 2017-02-01 | 最終更新日 | 2018-06-13 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure-based drug design identifies polythiophenes as antiprion compounds. Sci Transl Med, 7, 2015
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2LBU
| HADDOCK calculated model of Congo red bound to the HET-s amyloid | 分子名称: | Small s protein, sodium 3,3'-(1E,1'E)-biphenyl-4,4'-diylbis(diazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) | 著者 | Schutz, A.K, Soragni, A, Hornemann, S, Aguzzi, A, Ernst, M, Bockmann, A, Meier, B.H. | 登録日 | 2011-04-07 | 公開日 | 2011-06-01 | 最終更新日 | 2011-07-13 | 実験手法 | SOLID-STATE NMR | 主引用文献 | The Amyloid-Congo Red Interface at Atomic Resolution. Angew.Chem.Int.Ed.Engl., 2011
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4J8R
| Structure of an octapeptide repeat of the prion protein bound to the POM2 Fab antibody fragment | 分子名称: | Heavy chain of POM2 Fab, Light chain of POM2 Fab, Major prion protein | 著者 | Swayampakula, M, Baral, P.K, Kav, N.N.V, Aguzzi, A, James, M.N.G. | 登録日 | 2013-02-14 | 公開日 | 2013-05-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.303 Å) | 主引用文献 | The crystal structure of an octapeptide repeat of the Prion protein in complex with a Fab fragment of the POM2 antibody. Protein Sci., 22, 2013
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4DGI
| Structure of POM1 FAB fragment complexed with human PrPc Fragment 120-230 | 分子名称: | Major prion protein, POM1 Fab Heavy chain, POM1 Fab Light chain, ... | 著者 | Baral, P.K, Wieland, B, Swayampakula, M, James, M.N. | 登録日 | 2012-01-26 | 公開日 | 2012-10-31 | 最終更新日 | 2013-01-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural studies on the folded domain of the human prion protein bound to the Fab fragment of the antibody POM1. Acta Crystallogr.,Sect.D, 68, 2012
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6AQ7
| Structure of POM6 FAB fragment complexed with mouse PrPc | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, GLYCEROL, Major prion protein, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2017-08-18 | 公開日 | 2018-04-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion. FEBS J., 285, 2018
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4MA7
| Crystal structure of mouse prion protein complexed with Promazine | 分子名称: | Major prion protein, POM1 heavy chain, POM1 light chain, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2013-08-15 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural basis of prion inhibition by phenothiazine compounds. Structure, 22, 2014
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4MA8
| Crystal structure of mouse prion protein complexed with Chlorpromazine | 分子名称: | 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Major prion protein, POM1 heavy chain, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2013-08-15 | 公開日 | 2014-01-22 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of prion inhibition by phenothiazine compounds. Structure, 22, 2014
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4H88
| Structure of POM1 FAB fragment complexed with mouse PrPc Fragment 120-230 | 分子名称: | Major prion protein, POM1 FAB CHAIN H, POM1 FAB CHAIN L, ... | 著者 | Baral, P.K, Wieland, B, Swayampakula, M, James, M.N. | 登録日 | 2012-09-21 | 公開日 | 2013-07-31 | 最終更新日 | 2013-09-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature, 501, 2013
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4YX2
| Crystal structure of Bovine prion protein complexed with POM1 FAB | 分子名称: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2015-03-22 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | 主引用文献 | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXL
| Crystal structure of Syrian hamster prion protein complexed with POM1 FAB | 分子名称: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2015-03-23 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.604 Å) | 主引用文献 | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXH
| Crystal structure of Deer prion protein complexed with POM1 FAB | 分子名称: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2015-03-23 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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4YXK
| Crystal structure of Elk prion protein complexed with POM1 FAB | 分子名称: | Major prion protein, POM1 FAB HEAVY CHAIN, POM1 FAB LIGHT CHAIN, ... | 著者 | Baral, P.K, Swayampakula, M, James, M.N.G. | 登録日 | 2015-03-23 | 公開日 | 2015-09-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.805 Å) | 主引用文献 | X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins. J.Struct.Biol., 192, 2015
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