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1YP1
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BU of 1yp1 by Molmil
Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase from venom of Agkistrodon acutus
Descriptor: FII, KNL, ZINC ION
Authors:Lou, Z, Hou, J, Chen, J, Liang, X, Qiu, P, Liu, Y, Li, M, Rao, Z.
Deposit date:2005-01-28
Release date:2006-01-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a non-hemorrhagic fibrin(ogen)olytic metalloproteinase complexed with a novel natural tri-peptide inhibitor from venom of Agkistrodon acutus
J.Struct.Biol., 152, 2005
3K3E
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BU of 3k3e by Molmil
Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691
Descriptor: 1-(2-chlorophenyl)-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
Authors:Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H.
Deposit date:2009-10-02
Release date:2010-02-16
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
6IX8
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BU of 6ix8 by Molmil
The structure of LepI C52A in complex with SAM and its substrate analogue
Descriptor: (1R,2R,4aS,8S,8aR)-2,8-dimethyl-5'-phenyl-4a,5,6,7,8,8a-hexahydro-2H,2'H-spiro[naphthalene-1,3'-pyridine]-2',4'(1'H)-dione, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
Deposit date:2018-12-09
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.659 Å)
Cite:Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
3ZDT
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BU of 3zdt by Molmil
Crystal structure of basic patch mutant FAK FERM domain FAK31- 405 K216A, K218A, R221A, K222A
Descriptor: FOCAL ADHESION KINASE 1
Authors:Goni, G.M, Epifano, C, Boskovic, J, Camacho-Artacho, M, Zhou, J, Martin, M.T, Eck, M.J, Kremer, L, Graeter, F, Gervasio, F.L, Perez-Moreno, M, Lietha, D.
Deposit date:2012-11-30
Release date:2012-12-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Phosphatidylinositol 4,5-Bisphosphate Triggers Activation of Focal Adhesion Kinase by Inducing Clustering and Conformational Changes.
Proc.Natl.Acad.Sci.USA, 111, 2014
6IX5
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BU of 6ix5 by Molmil
The structure of LepI complex with SAM and its substrate analogue
Descriptor: 1,2-ETHANEDIOL, 4-hydroxy-3-[(2S,6E,8E)-2-methyldeca-6,8-dienoyl]-5-phenylpyridin-2(1H)-one, CHLORIDE ION, ...
Authors:Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
Deposit date:2018-12-09
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX3
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BU of 6ix3 by Molmil
The structure of LepI complex with SAM
Descriptor: CHLORIDE ION, O-methyltransferase lepI, S-ADENOSYLMETHIONINE
Authors:Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
Deposit date:2018-12-09
Release date:2019-07-17
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
6IX9
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BU of 6ix9 by Molmil
The structure of LepI C52A in complex with SAM and leporin C
Descriptor: (6R,6aS,10S,10aR)-10-methyl-4-phenyl-6-[(1E)-prop-1-en-1-yl]-2,6,6a,7,8,9,10,10a-octahydro-1H-[2]benzopyrano[4,3-c]pyridin-1-one, CHLORIDE ION, GLYCEROL, ...
Authors:Cai, Y, Ohashi, M, Hai, Y, Tang, Y, Zhou, J.
Deposit date:2018-12-09
Release date:2019-07-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI.
Nat.Chem., 11, 2019
3K3H
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BU of 3k3h by Molmil
Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691
Descriptor: 1-(2-chlorophenyl)-6-[(2S)-3,3,3-trifluoro-2-methylpropyl]-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
Authors:Wang, H, Luo, X, Ye, M, Hou, J, Robinson, H, Ke, H.
Deposit date:2009-10-02
Release date:2010-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into Binding of Phosphodiesterase-9A Selective Inhibitors by Crystal Structures and Mutagenesis
J.Med.Chem., 53, 2010
2OUP
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BU of 2oup by Molmil
crystal structure of PDE10A
Descriptor: MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUU
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BU of 2ouu by Molmil
crystal structure of PDE10A2 mutant D674A in complex with cGMP
Descriptor: GUANOSINE-3',5'-MONOPHOSPHATE, MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUS
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BU of 2ous by Molmil
crystal structure of PDE10A2 mutant D674A
Descriptor: MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
4MYS
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BU of 4mys by Molmil
1.4 Angstrom Crystal Structure of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase with SHCHC and Pyruvate
Descriptor: 2-(3-CARBOXYPROPIONYL)-6-HYDROXY-CYCLOHEXA-2,4-DIENE CARBOXYLIC ACID, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, GLYCEROL, ...
Authors:Sun, Y, Yin, S, Feng, Y, Li, J, Zhou, J, Liu, C, Zhu, G, Guo, Z.
Deposit date:2013-09-28
Release date:2014-04-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Molecular basis of the general base catalysis of an alpha / beta-hydrolase catalytic triad.
J.Biol.Chem., 289, 2014
2OUQ
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BU of 2ouq by Molmil
crystal structure of PDE10A2 in complex with GMP
Descriptor: GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUR
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BU of 2our by Molmil
crystal structure of PDE10A2 mutant D674A in complex with cAMP
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUN
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BU of 2oun by Molmil
crystal structure of PDE10A2 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H, Ke, H.M.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUY
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BU of 2ouy by Molmil
crystal structure of pde10a2 mutant D564A in complex with cAMP.
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, MAGNESIUM ION, ZINC ION, ...
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2OUV
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BU of 2ouv by Molmil
crystal structure of pde10a2 mutant of D564N
Descriptor: MAGNESIUM ION, ZINC ION, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Authors:Wang, H.C, Liu, Y.D, Hou, J, Zheng, M.Y, Robinson, H.
Deposit date:2007-02-12
Release date:2007-03-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:From the Cover: Structural insight into substrate specificity of phosphodiesterase 10.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2IS9
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BU of 2is9 by Molmil
Structure of yeast DCN-1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Defective in cullin neddylation protein 1, ...
Authors:Yang, X, Zhou, J, Sun, L, Wei, Z, Gao, J, Gong, W, Xu, R.M, Rao, Z, Liu, Y.
Deposit date:2006-10-16
Release date:2007-06-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural basis for the function of DCN-1 in protein Neddylation.
J.Biol.Chem., 282, 2007
3ZQJ
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BU of 3zqj by Molmil
Mycobacterium tuberculosis UvrA
Descriptor: UVRABC SYSTEM PROTEIN A, ZINC ION
Authors:Rossi, F, Khanduja, J.S, Bortoluzzi, A, Houghton, J, Sander, P, Guthlein, C, Davis, E.O, Springer, B, Bottger, E.C, Relini, A, Penco, A, Muniyappa, K, Rizzi, M.
Deposit date:2011-06-09
Release date:2011-06-22
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Biological and Structural Characterization of Mycobacterium Tuberculosis Uvra Provides Novel Insights Into its Mechanism of Action
Nucleic Acids Res., 39, 2011
8JLV
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BU of 8jlv by Molmil
Beneficial flip of substrate orientation enable determine substrate specificity for zearalenone lactone hydrolase
Descriptor: AB hydrolase-1 domain-containing protein
Authors:Xiang, L, Wang, M, Zhang, G, Zhou, J.
Deposit date:2023-06-02
Release date:2023-12-06
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.998636 Å)
Cite:Enhancing the activity of zearalenone lactone hydrolase toward the more toxic alpha-zearalanol via a single-point mutation.
Appl.Environ.Microbiol., 90, 2024
8JN0
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BU of 8jn0 by Molmil
N/F domain of alkaline amylase Amy703
Descriptor: Alpha-amylase
Authors:Xiang, L, Zhang, G, Zhou, J.
Deposit date:2023-06-05
Release date:2023-12-13
Method:X-RAY DIFFRACTION (1.22826374 Å)
Cite:Truncation of N-terminus domain of alkaline a-amylase to form a unique dimer leads to improved activity and stability and decreased calcium ion dependence
To Be Published
8JNX
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BU of 8jnx by Molmil
alkaline amylase Amy703 with truncated of N-terminus domain
Descriptor: Alpha-amylase, CALCIUM ION
Authors:Xiang, L, Zhang, G, Zhou, J.
Deposit date:2023-06-06
Release date:2023-12-13
Method:X-RAY DIFFRACTION (3.20279884 Å)
Cite:Truncation of N-terminus domain of alkaline a-amylase to form a unique dimer leads to improved activity and stability and decreased calcium ion dependence
To Be Published
4UUQ
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BU of 4uuq by Molmil
Crystal structure of human mono-glyceride lipase in complex with SAR127303
Descriptor: 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid, MONOGLYCERIDE LIPASE
Authors:Griebel, G, Pichat, P, Beeske, S, Leroy, T, Redon, N, Francon, D, Bert, L, Even, L, Lopez-Grancha, M, Tolstykh, T, Sun, F, Yu, Q, Brittain, S, Arlt, H, He, T, Zhang, B, Wiederschain, D, Bertrand, T, Houtman, J, Rak, A, Vallee, F, Michot, N, Auge, F, Menet, V, Bergis, O.E, George, P, Avenet, P, Mikol, V, Didier, M, Escoubet, J.
Deposit date:2014-07-30
Release date:2015-01-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents.
Sci.Rep., 5, 2015
6JJ8
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BU of 6jj8 by Molmil
Crystal structure of OsHXK6-ATP-Mg2+ complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:He, C, Wei, P, Chen, J, Wang, H, Wan, Y, Zhou, J, Zhu, Y, Huang, W, Yin, L.
Deposit date:2019-02-25
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of OsHXK6-ATP-Mg2+ complex
To Be Published
4XBX
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BU of 4xbx by Molmil
Crystal Structure of the L74F/M78F/L103V/L114V/I116V/F139V/L147V mutant of LEH
Descriptor: Limonene-1,2-epoxide hydrolase
Authors:Kong, X.D, Sun, Z, Xu, J.H, Reetz, M.T, Zhou, J.
Deposit date:2014-12-17
Release date:2015-07-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Reshaping an Enzyme Binding Pocket for Enhanced and Inverted Stereoselectivity: Use of Smallest Amino Acid Alphabets in Directed Evolution
Angew.Chem.Int.Ed.Engl., 54, 2015

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