2H1Y
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3PRE
| Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. | Descriptor: | 2-amino-8-(trans-4-methoxycyclohexyl)-4-methyl-6-(1H-pyrazol-3-yl)pyrido[2,3-d]pyrimidin-7(8H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Authors: | Knighton, D.R, Greasley, S.E, Rodgers, C.M.-L. | Deposit date: | 2010-11-29 | Release date: | 2011-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Quinazolines with intra-molecular hydrogen bonding scaffold (iMHBS) as PI3K/mTOR dual inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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3PRZ
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3PS6
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8X6B
| Crystal structure of immune receptor PVRIG in complex with ligand Nectin-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nectin-2, Transmembrane protein PVRIG | Authors: | Hu, S.T, Han, P, Wang, H, Qi, J.X. | Deposit date: | 2023-11-21 | Release date: | 2024-04-24 | Last modified: | 2024-07-24 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the immune recognition and selectivity of the immune receptor PVRIG for ligand Nectin-2. Structure, 32, 2024
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7CH4
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7CHC
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7CH5
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7E7E
| The co-crystal structure of ACE2 with Fab | Descriptor: | Processed angiotensin-converting enzyme 2, ZINC ION, h11B11-Fab | Authors: | Xiao, J.Y, Zhang, Y. | Deposit date: | 2021-02-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | A broadly neutralizing humanized ACE2-targeting antibody against SARS-CoV-2 variants. Nat Commun, 12, 2021
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7BWN
| Crystal Structure of a Designed Protein Heterocatenane | Descriptor: | Cellular tumor antigen p53, Chimera of Green fluorescent protein and p53dim | Authors: | Liu, Y.J, Duan, Z.L, Fang, J, Zhang, F, Xiao, J.Y, Zhang, W.B. | Deposit date: | 2020-04-15 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.396 Å) | Cite: | Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane. Angew.Chem.Int.Ed.Engl., 59, 2020
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8WY4
| GajA tetramer with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-10-30 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8X51
| Structure of DNA-bound GajA dimer (focused refinement) | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*TP*T)-3'), ... | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-11-16 | Release date: | 2024-02-28 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.92 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8X5I
| Structure of ATP/Mg2+ bound Gabija GajA | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA, MAGNESIUM ION | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-11-17 | Release date: | 2024-02-28 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8X5N
| Structure of ATP/Mg2+ bound Gabija GajA-GajB 4:4 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA, Gabija protein GajB, ... | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-11-17 | Release date: | 2024-02-28 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8WY5
| Structure of Gabija GajA in complex with DNA | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*T)-3'), ... | Authors: | Li, J, Wang, Z, Wang, L. | Deposit date: | 2023-10-30 | Release date: | 2024-02-28 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Structures and activation mechanism of the Gabija anti-phage system. Nature, 629, 2024
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8JFL
| PhK holoenzyme in active state, muscle isoform | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | Authors: | Yang, X.K, Xiao, J.Y. | Deposit date: | 2023-05-18 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture and activation of human muscle phosphorylase kinase. Nat Commun, 15, 2024
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8JFK
| PhK holoenzyme in inactive state, muscle isoform | Descriptor: | Calmodulin-1, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | Authors: | Yang, X.K, Xiao, J.Y. | Deposit date: | 2023-05-18 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture and activation of human muscle phosphorylase kinase. Nat Commun, 15, 2024
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8WHI
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8WHH
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8WHM
| Crystal structure of the ELKS2/LL5beta complex | Descriptor: | ERC protein 2, Pleckstrin homology-like domain family B member 2 | Authors: | Jia, X, Wei, Z. | Deposit date: | 2023-09-23 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CLASP-mediated competitive binding in protein condensates directs microtubule growth. Nat Commun, 15, 2024
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8Y6K
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8WHK
| Crystal structure of CLASP2 in complex with LL5beta | Descriptor: | CHLORIDE ION, CLIP-associating protein 2, Pleckstrin homology-like domain family B member 2 | Authors: | Jia, X, Wei, Z. | Deposit date: | 2023-09-23 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | CLASP-mediated competitive binding in protein condensates directs microtubule growth. Nat Commun, 15, 2024
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8WHJ
| Crystal structure of CLASP2 TOG4 fused with LL5beta | Descriptor: | CHLORIDE ION, CLIP-associating protein 2,Pleckstrin homology-like domain family B member 2, DI(HYDROXYETHYL)ETHER | Authors: | Jia, X, Wei, Z. | Deposit date: | 2023-09-23 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | CLASP-mediated competitive binding in protein condensates directs microtubule growth. Nat Commun, 15, 2024
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8WHL
| Crystal structure of CLASP2 in complex with CENP-E | Descriptor: | ACETATE ION, CLIP-associating protein 2, Centromere-associated protein E, ... | Authors: | Jia, X, Wei, Z. | Deposit date: | 2023-09-23 | Release date: | 2024-08-28 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | CLASP-mediated competitive binding in protein condensates directs microtubule growth. Nat Commun, 15, 2024
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3BM3
| Restriction endonuclease PspGI-substrate DNA complex | Descriptor: | CITRIC ACID, DNA (5'-D(*CP*AP*TP*CP*CP*AP*GP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*AP*CP*CP*TP*GP*GP*AP*T)-3'), ... | Authors: | Szczepanowski, R.H, Carpenter, M, Czapinska, H, Tamulaitis, G, Siksnys, V, Bhagwat, A, Bochtler, M. | Deposit date: | 2007-12-12 | Release date: | 2008-09-16 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A direct crystallographic demonstration that Type II restriction endonuclease PspGI flips nucleotides To be Published
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