7X0V
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![BU of 7x0v by Molmil](/molmil-images/mine/7x0v) | cryo-EM structure of human TRiC-ADP-AlFx | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-02-22 | Release date: | 2023-04-12 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X0S
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![BU of 7x0s by Molmil](/molmil-images/mine/7x0s) | Human TRiC-tubulin-S3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-02-22 | Release date: | 2023-04-12 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X0A
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![BU of 7x0a by Molmil](/molmil-images/mine/7x0a) | Cryo-EM structure of human TRiC-NPP state | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-02-21 | Release date: | 2023-04-12 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X3U
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![BU of 7x3u by Molmil](/molmil-images/mine/7x3u) | cryo-EM structure of human TRiC-ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-03-01 | Release date: | 2023-06-07 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X3J
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![BU of 7x3j by Molmil](/molmil-images/mine/7x3j) | Cryo-EM structure of human TRiC-tubulin-S2 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-03-01 | Release date: | 2023-06-07 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X6Q
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![BU of 7x6q by Molmil](/molmil-images/mine/7x6q) | cryo-EM structure of human TRiC-ATP-closed state | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-03-08 | Release date: | 2023-06-07 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X7Y
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![BU of 7x7y by Molmil](/molmil-images/mine/7x7y) | Cryo-EM structure of Human TRiC-ATP-open state | Descriptor: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | Authors: | Cong, Y, Liu, C.X. | Deposit date: | 2022-03-10 | Release date: | 2023-06-07 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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2FZN
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![BU of 2fzn by Molmil](/molmil-images/mine/2fzn) | |
2FZM
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![BU of 2fzm by Molmil](/molmil-images/mine/2fzm) | |
7UC6
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![BU of 7uc6 by Molmil](/molmil-images/mine/7uc6) | Stat5a Core in complex with Compound 12 | Descriptor: | N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(4-bromophenyl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2022-03-16 | Release date: | 2023-02-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (3.101 Å) | Cite: | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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7UBT
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![BU of 7ubt by Molmil](/molmil-images/mine/7ubt) | Stat5a Core in complex with Compound 18 | Descriptor: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1,3-benzothiazol-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2022-03-15 | Release date: | 2023-02-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.352 Å) | Cite: | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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7UC7
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![BU of 7uc7 by Molmil](/molmil-images/mine/7uc7) | Stat5a Core in complex with Compound 17 | Descriptor: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N~3~-(1-benzofuran-5-yl)-N,N-dimethyl-beta-alaninamide, Signal transducer and activator of transcription 5A | Authors: | Meagher, J.L, Stuckey, J.A. | Deposit date: | 2022-03-16 | Release date: | 2023-02-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.102 Å) | Cite: | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. J.Med.Chem., 66, 2023
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1AEL
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![BU of 1ael by Molmil](/molmil-images/mine/1ael) | |
1B4M
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![BU of 1b4m by Molmil](/molmil-images/mine/1b4m) | NMR STRUCTURE OF APO CELLULAR RETINOL-BINDING PROTEIN II, 24 STRUCTURES | Descriptor: | CELLULAR RETINOL-BINDING PROTEIN II | Authors: | Lu, J, Lin, C.-L, Tang, C, Ponder, J.W, Kao, J.L.F, Cistola, D.P, Li, E. | Deposit date: | 1998-12-23 | Release date: | 1999-04-27 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The structure and dynamics of rat apo-cellular retinol-binding protein II in solution: comparison with the X-ray structure. J.Mol.Biol., 286, 1999
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7VS3
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![BU of 7vs3 by Molmil](/molmil-images/mine/7vs3) | The crystal structure of rat calcium-dependent activator protein for secretion (CAPS) C2PH | Descriptor: | Calcium-dependent secretion activator 1, SULFATE ION | Authors: | Zhou, H, Wei, Z.Q, Zhang, L, Ren, Y.J, Ma, C. | Deposit date: | 2021-10-25 | Release date: | 2023-02-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.595 Å) | Cite: | The C 2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca 2+ -regulated exocytosis. Structure, 31, 2023
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7WVH
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![BU of 7wvh by Molmil](/molmil-images/mine/7wvh) | |
1EII
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![BU of 1eii by Molmil](/molmil-images/mine/1eii) | NMR STRUCTURE OF HOLO CELLULAR RETINOL-BINDING PROTEIN II | Descriptor: | CELLULAR RETINOL-BINDING PROTEIN II, RETINOL | Authors: | Lu, J, Lin, C.L, Tang, C, Ponder, J.W, Kao, J.L, Cistola, D.P, Li, E. | Deposit date: | 2000-02-25 | Release date: | 2000-08-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Binding of retinol induces changes in rat cellular retinol-binding protein II conformation and backbone dynamics. J.Mol.Biol., 300, 2000
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3CBS
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![BU of 3cbs by Molmil](/molmil-images/mine/3cbs) | CELLULAR RETINOIC ACID BINDING PROTEIN II IN COMPLEX WITH A SYNTHETIC RETINOIC ACID (RO-12 7310) | Descriptor: | (2E,4E,6E,8E)-9-(4-hydroxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid, PROTEIN (CRABP-II) | Authors: | Chaudhuri, B, Kleywegt, G.J, Bergfors, T, Jones, T.A. | Deposit date: | 1999-02-22 | Release date: | 1999-12-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids. Acta Crystallogr.,Sect.D, 55, 1999
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1URE
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7VIG
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![BU of 7vig by Molmil](/molmil-images/mine/7vig) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIE
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![BU of 7vie by Molmil](/molmil-images/mine/7vie) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with S1P | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIF
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![BU of 7vif by Molmil](/molmil-images/mine/7vif) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with (S)-FTY720-P | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7VIH
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![BU of 7vih by Molmil](/molmil-images/mine/7vih) | Cryo-EM structure of Gi coupled Sphingosine 1-phosphate receptor bound with CBP-307 | Descriptor: | 1-[[2-fluoranyl-4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yu, L.Y, Gan, B, Xiao, Q.J, Ren, R.B. | Deposit date: | 2021-09-26 | Release date: | 2022-09-28 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into sphingosine-1-phosphate receptor activation. Proc.Natl.Acad.Sci.USA, 119, 2022
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7WSO
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![BU of 7wso by Molmil](/molmil-images/mine/7wso) | Structure of a membrane protein G | Descriptor: | B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein beta chain, Immunoglobulin heavy constant gamma 1 | Authors: | Ma, X, Zhu, Y, Chen, Y, Huang, Z. | Deposit date: | 2022-01-30 | Release date: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Cryo-EM structures of two human B cell receptor isotypes. Science, 377, 2022
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7WMV
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![BU of 7wmv by Molmil](/molmil-images/mine/7wmv) | Structure of human SGLT1-MAP17 complex bound with LX2761 | Descriptor: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | Authors: | Chen, L, Niu, Y, Cui, W. | Deposit date: | 2022-01-17 | Release date: | 2022-11-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural mechanism of SGLT1 inhibitors. Nat Commun, 13, 2022
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